Results 71 to 80 of about 601,814 (301)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

open access: yesFEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar   +4 more
wiley   +1 more source

Is Auditor Independence Influenced by Non-Audit Services? A Stakeholders’ Viewpoint [PDF]

open access: yesPakistan Journal of Commerce and Social Sciences, 2020
The auditor may provide numerous services to their clients covering audit and non-audit services (NAS). These services have been considered as a combination of services offering varying results for client firms.
Muhammad Ramzan   +2 more
doaj  

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

open access: yesFEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão   +3 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

open access: yesFEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose   +9 more
wiley   +1 more source

Guidelines for developing policies for student activity programs

open access: yes, 2002
[Rev. (4/02)].; Title from PDF cover (viewed Dec. 15, 2004).; "Auditor of State, Betty Montgomery."; "April, 2002."; Harvested from the web on 12/15/04Rev.
Ohio. Auditor of State
core  

Annual report 2014–15: auditing in the public interest [PDF]

open access: yes, 2015
The Annual Report 2014–15 provides a summary of the performance of Victorian Auditor-General\u27s Office (VAGO) in 2014–15 in fulfilling our purpose to provide assurance to Parliament on the accountability and performance of Victoria’s public sector ...
Victorian Auditor-General
core  

UNHA ANÁLISE DA INDEPENDENCIA NA AUDITORÍA DE CONTAS

open access: yesRevista Galega de Economía, 2013
The goodness of the audit process depends on how it happen in auditor's mind who does it, how it happen its phases, its content and completion. Auditor independence becomes one of the fundamental pillars of the exercise of audit activity. The aim of this
ANA MARÍA MARTÍNEZ-PINA GARCÍA
doaj  

Can auditors be independent? – Experimental evidence [PDF]

open access: yes, 2007
The Sarbanes-Oxley Act of 2002 has transformed the institutional environment in the US by making the audit committee responsible for the appointment, compensation and oversight of the auditor. We examine whether this institutional change successfully resolves the alleged problem of an unconscious favoring of the management (Bazerman et al.
Koch, Christopher   +2 more
openaire   +2 more sources

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