Results 81 to 90 of about 501,394 (311)

Reserves, Injury Severity, and Outcomes in Traumatic Brain Injury: A CENTER‐TBI Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Reserve refers to the brain's ability to maintain function after an injury and strongly relates to traumatic brain injury (TBI) outcomes. This study examined (1) whether associations between pre‐injury reserve proxies and outcomes differed across injury severity categories, and (2) whether the impact of injury severity varied across ...
Natascha Ekdahl, Marika C. Möller, Lindsay Wilson, Anne Vik, Toril Skandsen, Jonas Stenberg, CENTER‐TBI participants and investigators   +6 more
wiley   +1 more source

Gene therapy for deafness: are we there now?

EMBO Molecular Medicine
Approximately half a billion people—5% of the world’s population—suffer from disabling hearing impairment (HI) according to the WHO ( http://www.who.int/features/factfiles/deafness/en/ ).
Tobias Moser, Han Chen, Kathrin Kusch, Rüdiger Behr, Barbara Vona   +4 more
doaj   +1 more source

Quantitative optical nanophysiology of Ca2+ signaling at inner hair cell active zones

Nature Communications, 2018
Quantitatively studying components of the presynapse requires high resolution optical methods. Here the authors use confocal microscopy as well as 2D- and 3D-STED nanoscopy to quantify the number and activity of active zone Ca2+ channels in inner hair ...
Jakob Neef, Nicolai T. Urban, Tzu-Lun Ohn, Thomas Frank, Philippe Jean, Stefan W. Hell, Katrin I. Willig, Tobias Moser   +7 more
doaj   +1 more source

Cerebrospinal Fluid Over Plasma Links Analytes to Cognitive Decline in Older Adults at Risk for Alzheimer's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To identify inflammatory analytes in cerebrospinal fluid (CSF) and plasma associated with cognitive decline in cognitively normal (CN) older adults at risk for Alzheimer's disease (AD). Methods In a longitudinal study of 118 CN older adults (65–80 years, 54% APOE ε4, 26% preclinical AD), 1331 CSF and 1501 plasma analytes were ...
Jagan A. Pillai, Audrey Zhu, Chunxuan Ma, Ming Wang, Yifan Yang, Lynn M. Bekris, Maria Khrestian, Frank P. DiFilippo, Mikhail Nasrallah, Aaron Burberry, James B. Leverenz, Yuan Hou, Feixiong Cheng, Stephen M. Rao   +13 more
wiley   +1 more source

Perceptual consequences of including reverberation in spatial auditory displays

, 2003
Proceedings of the 9th International Conference on Auditory Display (ICAD), Boston, MA, July 7-9, 2003.Presented at the 9th International Conference on Auditory Display (ICAD), Boston, MA, July 7-9, 2003.This paper evaluates the perceptual consequences ...
Shinn-Cunningham, Barbara, Devore, Sasha
core  

Risk of Retinopathy Associated with Long‐Term Use of Hydroxychloroquine in Patients with Rheumatic Diseases: A Systematic Review and Meta‐Analysis

Arthritis Care &Research, EarlyView.
Objective We aimed to estimate the prevalence and cumulative incidence of hydroxychloroquine retinopathy (HCQ‐R) and its risk factors among patients receiving long‐term HCQ with rheumatic diseases through a systematic review and meta‐analysis of observational studies that used spectral‐domain optical coherence tomography (SD‐OCT) for screening ...
Narsis Daftarian, Chloe Yue, Steve D Levasseur, Hui Xie, J. Antonio Avina‐Zubieta   +4 more
wiley   +1 more source

Optical measurement of glutamate release robustly reports short-term plasticity at a fast central synapse

Frontiers in Molecular Neuroscience
IntroductionRecently developed fluorescent neurotransmitter indicators have enabled direct measurements of neurotransmitter in the synaptic cleft. Precise optical measurements of neurotransmitter release may be used to make inferences about presynaptic ...
Paul Jakob Habakuk Hain, Paul Jakob Habakuk Hain, Tobias Moser, Tobias Moser   +3 more
doaj   +1 more source

A Return to Normality: A Descriptive Qualitative Interview Study Exploring the Patient Experience of Gout Flare Resolution

Arthritis Care &Research, EarlyView.
Objective Although the definition of a gout flare is well established, the state of gout flare resolution has not yet been defined. This study aimed to explore patients’ experiences and perceptions of gout flare resolution. Methods Semistructured interviews were conducted with 24 people with gout, guided by open‐ended questions exploring their ...
Sarah Stewart, Anne Horne, Angelo Gaffo, Lisa K. Stamp, N. Lawrence Edwards, Nicola Dalbeth   +5 more
wiley   +1 more source

The impact of visual gaze direction on auditory object tracking

Scientific Reports, 2017
Subjective experience suggests that we are able to direct our auditory attention independent of our visual gaze, e.g when shadowing a nearby conversation at a cocktail party. But what are the consequences at the behavioural and neural level?
Ulrich Pomper, Maria Chait
doaj   +1 more source

Auditory scene analysis as the basis for designing auditory widgets

, 1997
Presented at the 4th International Conference on Auditory Display (ICAD), Palo Alto, California, November 2-5, 1997.Presented at the 4th International Conference on Auditory Display (ICAD), Palo Alto, California, November 2-5, 1997.This paper presents a ...
Edwards, Alistair D.N, Mitsopoulos, Evangelos N   +1 more
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