Results 51 to 60 of about 63,111 (319)

Loss of auditory sensitivity from inner hair cell synaptopathy can be centrally compensated in the young but not old brain [PDF]

, 2016
A dramatic shift in societal demographics will lead to rapid growth in the number of older people with hearing deficits. Poorer performance in suprathreshold speech understanding and temporal processing with age has been previously linked with ...
Altschuler, Backoff, Bharadwaj, Boettcher, Bramhall, Brenner, Brigande, Cai, Canlon, Caspary, Chumak, Costalupes, Dan Bing, Dehmel, Dolphin, Dorit Möhrle, Duncker, Engel, Fernandez, Frisina, Frisina, Frisina, Furman, Füllgrabe, Gates, Gordon-Salant, Gröschel, Gröschel, Gu, Hage, He, Heeringa, Heidrych, Heil, Heinz, Heinz, Herman, Kaltenbach, Khimich, Knipper, Knipper, Konkle, Ksenya Varakina, Kujawa, Kumar, Kun Ni, Kuwada, Levakova, Lorenzi, Lukas Rüttiger, Marcotti, Marlies Knipper, Melcher, Meyer, Middleton, Montgomery, Müller, Navarro-Martinez, Newman, Ouda, Ouda, Parham, Parthasarathy, Picton, Rance, Ruel, Ruel, Rüttiger, Rüttiger, Salvi, Schaette, Schaette, Schaette, Schmiedt, Sergeyenko, Singer, Snell, Steel, Sze Chim Lee, Takahashi, Tan, Ulrike Zimmermann, Viana, Vogler, Wang, Weber, Wingfield, Zampini, Zheng, Zuccotti, Zuccotti, Šuta   +91 more
core   +1 more source

Pinoresinol Diglucoside Attenuates Nuclear Receptor Coactivator 4‐Mediated Ferritinophagy Associated with Cisplatin‐Induced Hearing Loss

Advanced Science, EarlyView.
Pinoresinol diglucoside, a bioactive component extracted from traditional Chinese medicine, attenuates cisplatin‐induced ototoxicity in vivo and in vitro. The protective effect is achieved by downregulation of Socs1. The present study is the first to investigate the expression and function of Socs1 in inner ear, which is known to promote ferroptosis ...
Yin Chen, Cheng Cheng, Ao Li, Dengbin Ma, Siyu Li, Handong Wang, Song Gao, Dingding Liu, Panpan Song, Chenjie Yu, Xiaoyun Qian, Guoqiang Wan, Xia Gao   +12 more
wiley   +1 more source

The functional role of GABA and glycine in monaural and binaural processing in the inferior colliculus of horseshoe bats [PDF]

, 1992
The functional role of GABA and glycine in monaural and binaural signal analysis was studied in single unit recordings from the central nucleus of the inferior colliculus (IC) of horseshoe bats (Rhinolophus rouxi) employing microiontophoresis of the ...
Grothe, Benedikt, Habbicht, Hartmann, Kössl, Manfred, Vater, Marianne   +3 more
core   +1 more source

Ipsilateral and Contralateral Auditory Brainstem Response Reorganization in Hemispherectomized Patients

Neural Plasticity, 2013
Background. Cortical hemispherectomy leads to degeneration of ipsilateral subcortical structures, which can be observed long term after the operation. Therefore, reorganization of the brainstem auditory pathway might occur.
Ning Yao, Hui Qiao, Ping Li, Yang Liu, Liang Wu, Xiaofeng Deng, Zide Wang, Daxing Chen, Xianzeng Tong, Yuan Liu, Chenlong Yang, Yulun Xu   +11 more
doaj   +1 more source

A Multifunctional Nanodelivery System Modified by Fusion Peptides Acts as Teriparatide Carrier for Noise‐Induced Hearing Loss Therapy

Advanced Science, EarlyView.
The fusion peptide LR27‐modified thermosensitive nanodelivery system exhibits both hair cell targeting and inner ear penetrating properties. This system sustainably and effectively delivers PTH1‐34 to the inner ear of a hearing loss mouse model via the synergistic effects of multiple peptides, achieving satisfactory hearing protection through ...
Jiawen Li, Zhuowen Hao, Fangzi Ke, Zhihui Liu, Weilong Wang, Sihui Wen, Fan Wu, Bowen Xu, Miao He, Shengyu Zou, Xiong Chen, Jingfeng Li, Zuhong He   +12 more
wiley   +1 more source

NOX2 Contributes to High‐Frequency Outer Hair Cell Vulnerability in the Cochlea

Advanced Science, EarlyView.
This study first identifies NOX2 as a differentially expressed gene related to oxidative damage in the apical and basal turns through single‐cell RNA sequencing. NOX2 gene knockout mitigates OHCs damage caused by neomycin and noise and enhances Nrf2 expression and nuclear translocation.
Meihao Qi, Zejun Gao, Yang Qiu, Renfeng Wang, Keyong Tian, Bo Yue, Xinyu Zhang, Peng Zhang, Ziqi Wu, Qingwen Zhu, Zhenzhen Liu, Zhuoyao Ma, Xueying Zhou, Yu Han, Jun Chen, Jianhua Qiu, DingJun Zha   +16 more
wiley   +1 more source

Assembly of the Auditory Circuitry by a Hox Genetic Network in the Mouse Brainstem [PDF]

, 2013
Rhombomeres (r) contribute to brainstem auditory nuclei during development. Hox genes are determinants of rhombomere-derived fate and neuronal connectivity.
Andolfi, G., Avallone, B., Di Bonito, M., Franze, A. M., Mancuso, M., Narita, Y., Puelles, L., Rijli, F. M., Sequino, L., Studer, M.   +9 more
core   +5 more sources

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

Advanced Science, EarlyView.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei, Shiwei Qiu, Xue Gao, Lu Zheng, Yijin Chen, Ying Ma, Haifeng Feng, Jinyuan Yang, Guojie Dong, Huiyi Nie, Weihao Zhao, Xiaoge Li, Guangqin Wang, Wei Xiong, Pu Dai, Yongyi Yuan   +15 more
wiley   +1 more source

Consequences and Mechanisms of Noise‐Induced Cochlear Synaptopathy and Hidden Hearing Loss, With Focuses on Signal Perception in Noise and Temporal Processing

Advanced Science, EarlyView.
Noise‐induced synaptopathy (NIS) is largely reversible due to self‐repair. NIS and noise‐induced hidden hearing loss are two concepts with similarities and differences. The major hearing deficits in NIHHL are temporal processing disorders. The translation of animal data in NIS studies to humans is hindered by many factors.
Hui Wang, Steven J Aiken, Jian Wang
wiley   +1 more source

Auditory evoked potentials: predicting speech therapy outcomes in children with phonological disorders

Clinics, 2014
OBJECTIVES: This study investigated whether neurophysiologic responses (auditory evoked potentials) differ between typically developed children and children with phonological disorders and whether these responses are modified in children with ...
Renata Aparecida Leite, Haydée Fiszbein Wertzner, Isabela Crivellaro Gonçalves, Fernanda Cristina Leite Magliaro, Carla Gentile Matas   +4 more
doaj   +1 more source