Results 1 to 10 of about 409,796 (120)

Induced Cognitive Impairments Reversed by Grafts of Neural Precursors: A Longitudinal Study in a Macaque Model of Parkinson's Disease

Advanced Science, 2022
Parkinson's disease (PD) evolves over an extended and variable period in humans; years prior to the onset of classical motor symptoms, sleep and biological rhythm disorders develop, significantly impacting the quality‐of‐life of patients.
Florence Wianny, Kwamivi Dzahini, Karim Fifel, Charles Robert Eden Wilson, Agnieszka Bernat, Virginie Dolmazon, Pierre Misery, Camille Lamy, Pascale Giroud, Howard Michael Cooper, Kenneth Knoblauch, Emmanuel Procyk, Henry Kennedy, Pierre Savatier, Colette Dehay, Julien Vezoli   +15 more
doaj   +1 more source

Corticospinal neuron subpopulation-specific developmental genes prospectively indicate mature segmentally specific axon projection targeting

Cell Reports, 2021
Summary: For precise motor control, distinct subpopulations of corticospinal neurons (CSN) must extend axons to distinct spinal segments, from proximal targets in the brainstem and cervical cord to distal targets in thoracic and lumbar spinal segments ...
Vibhu Sahni, Sara J. Shnider, Denis Jabaudon, Janet H.T. Song, Yasuhiro Itoh, Luciano C. Greig, Jeffrey D. Macklis   +6 more
doaj   +1 more source

Dopamine modulates the retinal clock through melanopsin-dependent regulation of cholinergic waves during development

BMC Biology, 2023
Background The mammalian retina contains an autonomous circadian clock that controls various aspects of retinal physiology and function, including dopamine (DA) release by amacrine cells. This neurotransmitter plays a critical role in retina development,
Chaimaa Kinane, Hugo Calligaro, Antonin Jandot, Christine Coutanson, Nasser Haddjeri, Mohamed Bennis, Ouria Dkhissi-Benyahya   +6 more
doaj   +1 more source

Inter-axonal molecular crosstalk via Lumican proteoglycan sculpts murine cervical corticospinal innervation by distinct subpopulations

Cell Reports, 2023
Summary: How CNS circuits sculpt their axonal arbors into spatially and functionally organized domains is not well understood. Segmental specificity of corticospinal connectivity is an exemplar for such regional specificity of many axon projections ...
Yasuhiro Itoh, Vibhu Sahni, Sara J. Shnider, Holly McKee, Jeffrey D. Macklis   +4 more
doaj   +1 more source

Liver organoids in domestic animals: an expected promise for metabolic studies

Veterinary Research, 2021
The liver is one of the most important organs, both in terms of the different metabolic processes (energy, lipid, ferric, uric, etc.) and of its central role in the processes of detoxification of substances of food origin or noxious substances (alcohol ...
Camille Baquerre, Guillaume Montillet, Bertrand Pain   +2 more
doaj   +1 more source

Crim1 and Kelch-like 14 exert complementary dual-directional developmental control over segmentally specific corticospinal axon projection targeting

Cell Reports, 2021
Summary: The cerebral cortex executes highly skilled movement, necessitating that it connects accurately with specific brainstem and spinal motor circuitry.
Vibhu Sahni, Yasuhiro Itoh, Sara J. Shnider, Jeffrey D. Macklis   +3 more
doaj   +1 more source

Epigenetic status of H19/IGF2 and SNRPN imprinted genes in aborted and successfully derived embryonic stem cell lines in non-human primates

Stem Cell Research, 2016
The imprinted genes of primate embryonic stem cells (ESCs) often show altered DNA methylation. It is unknown whether these alterations emerge while deriving the ESCs. Here we studied the methylation patterns of two differentially methylated regions (DMRs)
Florence Wianny, Thierry Blachère, Murielle Godet, Rémi Guillermas, Véronique Cortay, Pierre-Yves Bourillot, Annick Lefèvre, Pierre Savatier, Colette Dehay   +8 more
doaj   +1 more source

Exploring the Acquisition and Production of Grammatical Constructions Through Human-Robot Interaction with Echo State Networks

Frontiers in Neurorobotics, 2014
One of the principal functions of human language is to allow people to coordinate joint action. This includes the description of events, requests for action, and their organization in time.
Xavier eHinaut, Xavier eHinaut, Maxime ePetit, Maxime ePetit, Grégoire ePointeau, Grégoire ePointeau, Peter F Dominey, Peter F Dominey, Peter F Dominey   +8 more
doaj   +1 more source

Potentiel des organoïdes cérébraux comme modèles d’étude des neuropathologies chez les animaux domestiques

INRAE Productions Animales, 2023
Le cerveau est un organe complexe et tout modèle pour l'étudier dans ses aspects normaux et pathologiques devient un outil de choix en neurobiologie. La maîtrise et la diffusion de protocoles permettant le développement d'organoïdes cérébraux ont ouvert
Bertrand PAIN , Noémie AURINE, Théo LA ROSA, Camille BAQUERRE, Muriel COULPIER   +4 more
doaj   +1 more source

Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice

Nature Communications, 2016
Rett syndrome is a neurodevelopmental disorder caused by mutations in Mecp2. Here the authors show that Mecp2 loss-of-function leads to upregulation of the NF-κB pathway, and that reducing NF-κB signalling ameliorates phenotypes of Mecp2-null mice, thus ...
Noriyuki Kishi, Jessica L. MacDonald, Julia Ye, Bradley J. Molyneaux, Eiman Azim, Jeffrey D. Macklis   +5 more
doaj   +1 more source