Results 11 to 20 of about 2,884,321 (263)

Persistent Wnt/β-catenin signaling determines dorsalization of the postnatal subventricular zone and neural Stem cell specification into oligodendrocytes and glutamatergic neurons [PDF]

open access: yes, 2014
In the postnatal and adult central nervous system (CNS), the subventricular zone (SVZ) of the forebrain is the main source of neural stem cells (NSCs) that generate olfactory neurons and oligodendrocytes (OLs), the myelinating cells of the CNS.
Raineteau, Olivier   +17 more
core   +1 more source

Drosophila Neural Stem Cells in Brain Development and Tumor Formation [PDF]

open access: yes, 2014
Neuroblasts, the neural stem cells in Drosophila, generate the complex neural structure of the central nervous system. Significant progress has been made in understanding the mechanisms regulating the self-renewal, proliferation, and differentiation in ...
Reichert, Heinrich, Jiang, Yanrui
core   +1 more source

Spatiotemporal evolution of early innate immune responses triggered by neural stem cell grafting [PDF]

open access: yes, 2012
INTRODUCTION: Transplantation of neural stem cells (NSCs) is increasingly suggested to become part of future therapeutic approaches to improve functional outcome of various central nervous system disorders. However, recently it has become clear that only
Van Der Linden, Anne-Marie   +24 more
core   +1 more source

Neural stem cells in Drosophila : molecular genetic mechanisms underlying normal neural proliferation and abnormal brain tumor formation [PDF]

open access: yes, 2012
Neural stem cells in Drosophila are currently one of the best model systems for understanding stem cell biology during normal development and during abnormal development of stem cell-derived brain tumors.
Heinrich Reichert   +3 more
core   +1 more source

Niche-independent symmetrical self-renewal of a mammalian tissue stem cell. [PDF]

open access: yes, 2005
Pluripotent mouse embryonic stem (ES) cells multiply in simple monoculture by symmetrical divisions. In vivo, however, stem cells are generally thought to depend on specialised cellular microenvironments and to undergo predominantly asymmetric divisions.
Luciano Conti   +68 more
core   +1 more source

NMDAR mediated translation at the synapse is regulated by MOV10 and FMRP

open access: yesMolecular Brain, 2019
Protein synthesis is crucial for maintaining synaptic plasticity and synaptic signalling. Here we have attempted to understand the role of RNA binding proteins, Fragile X Mental Retardation Protein (FMRP) and Moloney Leukemia Virus 10 (MOV10) protein in ...
Preeti Madhav Kute   +4 more
doaj   +1 more source

Radial Migration Dynamics Is Modulated in a Laminar and Area-Specific Manner During Primate Corticogenesis

open access: yesFrontiers in Cell and Developmental Biology, 2020
The orderly radial migration of cortical neurons from their birthplace in the germinal zones to their final destination in the cortical plate is a prerequisite for the functional assembly of microcircuits in the neocortex.
Veronique Cortay   +11 more
doaj   +1 more source

Cortical neurons derived from human pluripotent stem cells lacking FMRP display altered spontaneous firing patterns

open access: yesMolecular Autism, 2020
Background Fragile X syndrome (FXS), a neurodevelopmental disorder, is a leading monogenetic cause of intellectual disability and autism spectrum disorder.
Shreya Das Sharma   +15 more
doaj   +1 more source

The Oxygen and Glucose Deprivation of Immature Cells of the Nervous System Exerts Distinct Effects on Mitochondria, Mitophagy, and Autophagy, Depending on the Cells’ Differentiation Stage

open access: yesBrain Sciences, 2023
Perinatal brain damage, one of the most common causes of lifelong impairment, is predominantly caused by a lack of oxygen and glucose during early development.
Denis Jagečić   +4 more
doaj   +1 more source

NANOG Is Required for the Long-Term Establishment of Avian Somatic Reprogrammed Cells

open access: yesStem Cell Reports, 2018
Summary: Somatic reprogramming, which was first identified in rodents, remains poorly described in non-mammalian species. Here, we generated avian reprogrammed cells by reprogramming of chicken and duck primary embryonic fibroblasts.
Aurélie Fuet   +6 more
doaj   +1 more source

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