Embryonic cortical neural stem cells migrate ventrally and persist as postnatal striatal stem cells [PDF]
, 2006 Embryonic cortical neural stem cells apparently have a transient existence, as they do not persist in the adult cortex. We sought to determine the fate of embryonic cortical stem cells by following Emx1(IREScre); LacZ/EGFP double-transgenic murine cells ...
Seaberg, R.M. +18 more
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Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
ABC of Brain Stem Death: From Brain Death to Brain Stem Death
, 1982 In the second in a series of nine articles on brain death, a British neurologist traces the evolution of British and American criteria for establishing brain death, distinguishes between whole brain death and death of the brain stem, and describes the ...
Pallis, Christopher
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Conditional activation of Bmi1 in embryonic and postnatal neural stem/progenitor cells in mouse models: analysis of its effect on their biological properties and tumourigenesis [PDF]
, 2011 PhDThe Polycomb group protein Bmi1 is a key transcriptional regulator of self renewal of embryonic and adult neural stem and progenitor cells (NSPC) and its over-expression has been shown to occur in several types of brain tumour.
Yadırgı, Gökhan
core +4 more sources
Scientific Reports, 2018 The subventricular zone (SVZ) is a region of ongoing postnatal germinal activity that shows complex spatial heterogeneity. For instance, different SVZ microdomains contain neural stem cells that express distinct transcription factors and generate ...
Stefan Zweifel +4 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Comparative Analysis of the Frequency and Distribution of Stem and Progenitor Cells in the Adult Mouse Brain [PDF]
cells (NSCs) and progenitor cells, but it cannot discriminate between these two populations. Given two assays have purported to overcome this shortfall, we performed a comparative analysis of the distribution and frequency of NSCs and progenitor ...
Golmohammadi, Mohammed G. +17 more
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FACS purification and transcriptome analysis of drosophila neural stem cells reveals a role for Klumpfuss in self-renewal [PDF]
, 2012 Drosophila neuroblasts (NBs) have emerged as a model for stem cell biology that is ideal for genetic analysis but is limited by the lack of cell-type-specific gene expression data.
Jonas Steinmann +17 more
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Proton therapy in the treatment of diffuse astrocytoma of the brain stem. Case report
Сибирский онкологический журнал, 2022 Background. Despite the fact that cerebral astrocytoma belongs to low-grade tumors (grade II gliomas), it often leads to disability and death of patients.
T. A. Kireeva +5 more
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source