Results 91 to 100 of about 226,686 (358)

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Event-related brain potential correlates of human auditory sensory memory-trace formation [PDF]

, 2005
The event-related potential (ERP) component mismatch negativity (MMN) is a neural marker of human echoic memory. MMN is elicited by deviant sounds embedded in a stream of frequent standards, reflecting the deviation from an inferred memory trace of the ...
Baldeweg, T, Dwivedi, P, Gruzelier, JH, Haenschel, C, Vernon, DJ   +4 more
core  

The Geometry of Layer 2/3 Cortical Sound Processing in Slow Wave Sleep

Advanced Science, EarlyView.
Sleep is associated with a sensory disconnection whose mechanisms remain elusive. Large neuronal population recordings in the auditory cortex revealed that, in NREM sleep, the neural code for sounds is highly similar to wakefulness, but coordinated modulations of neuron responsiveness intermittently disconnect the local cortical networks from sensory ...
Allan Muller, Anton Filipchuk, Sophie Bagur, Brice Bathellier   +3 more
wiley   +1 more source

Auditory Connections and Functions of Prefrontal Cortex

Frontiers in Neuroscience, 2014
The functional auditory system extends from the ears to the frontal lobes with successively more complex functions occurring as one ascends the hierarchy of the nervous system.
Bethany ePlakke, Lizabeth M Romanski
doaj   +1 more source

Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors

Advanced Science, EarlyView.
Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen, Riya Gupta, Yosuke M. Morizawa, Yu Qin, Xingyu Du, Cynthia Pang, Osama Al‐Dalahmah, Maura B. Dupont, Guang Yang   +8 more
wiley   +1 more source

Subicular Astrocytes Govern Seizure‐Impaired Fear Memory

Advanced Science, EarlyView.
Astrocytes in dorsal subiculum act as a critical modulator of seizure‐associated cognitive dysfunction, operating through a Ca2+‐dependent adenosine‐linked astrocyte‐neuron signaling pathway that disrupts neuronal circuit homeostasis. This research highlights the potential of astrocyte‐targeted interventions as a therapeutic strategy, moving beyond the
Yuying Shao, Jing Xi, Yuhao Sun, Yulan Li, Zhisheng Li, Wangjialu Lu, Jialu Chen, Lin Yang, Fan Fei, Heming Cheng, Li Cheng, Cenglin Xu, Zhuo Huang, Vladimir Parpura, Yi Wang, Zhong Chen   +15 more
wiley   +1 more source

Shannon Entropy of Gray Matter Eigenmodes: A Novel Biomarker for Alzheimer's Disease and Heterogeneous MCI Trajectories

Advanced Science, EarlyView.
Entropy derived from gray matter eigenmodes captures cortical disorganization in Alzheimer's disease. Using multimodal MRI and amyloid‐PET data, this novel structure–function coupling biomarker enables accurate classification of clinical stages, predicts Aβ burden, and stratifies mild cognitive impairment subtypes.
Yumeng Li, Gaoping Long, Xinyue Zhang, Kewei Chen, Xin Li, Zhanjun Zhang   +5 more
wiley   +1 more source

Eye Movement-Related Activity in and below the Macaque Auditory Cortex

i-Perception, 2011
Recent studies have revealed influences of viewing scenes on sound processing and of gaze direction on sound location coding in the auditory cortex of the macaque monkey. We examined the spontaneous activity of auditory cortex in the darkness.
Yoshinao Kajikawa, Charles Schroeder
doaj   +1 more source

Enhanced peripheral visual processing in congenitally deaf humans is supported by multiple brain regions, including primary auditory cortex

Frontiers in Human Neuroscience, 2014
Brain reorganization associated with altered sensory experience clarifies the critical role of neuroplasticity in development. An example is enhanced peripheral visual processing associated with congenital deafness, but the neural systems supporting this
Gregory D. Scott, Gregory D. Scott, Christina M Karns, Mark W. Dow, Courtney eStevens, Courtney eStevens, Helen J Neville   +6 more
doaj   +1 more source