Results 91 to 100 of about 109,925 (302)

Intrinsically Mitochondria‐Targeting Nanozyme via Coordination‐Assembly of Natural Quercetin for Cascade Antioxidant Therapy of Cerebral Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
This study uncovers that quercetin naturally targets mitochondria. By coordinating quercetin with Fe3+, we engineer an ultrasmall cascade nanozyme (MCN) with superoxide dismutase‐catalase activities. MCN crosses the damaged blood–brain barrier, scavenges mitochondrial ROS, prevents mitochondrial DNA leakage, and blocks the cGAS‐STING pathway, thereby ...
Wenxuan Zheng, Zhicheng Wang, Xin Zhou, Shuya Wang, Xiaojing Shi, Tingli Xiong, Ruishi Li, Yuting Lin, Zhen Chen, Jiawen Wei, Fei Li, Jinwen Ge, Kelong Ai, Chong Liu, Guiming Deng   +14 more
wiley   +1 more source

Auditory cortex involvement in emotional learning and memory [PDF]

, 2015
Emotional memories represent the core of human and animal life and drive future choices and behaviors. Early research involving brain lesion studies in animals lead to the idea that the auditory cortex participates in emotional learning by processing the
Cambiaghi, Marco, Sacchetti, B, Concina, Giulia, Sacchetti, Benedetto, Sacco, Tiziana, Grosso, A, Grosso, Anna, Sacco, T, Cambiaghi, M, Concina, G   +9 more
core   +1 more source

Palmitoylation of PSD‐95 Orchestrates Learning‐Dependent Metaplasticity in the Amygdala and Fear Memory

Advanced Science, EarlyView.
This study reveals that fear learning specifically triggers PICK1/DHHC2‐dependent palmitoylation of PSD‐95 in the lateral amygdala. Fear conditioning induces the dissociation of DHHC5 from PSD‐95 and the association of PSD‐95 with DHHC2. DHHC2‐mediated palmitoylation of PSD‐95 is required for synaptic transmission and underlies fear learning–induced ...
Zu‐Cheng Shen, Yu‐Xuan Weng, Zhi‐Xuan Xia, Yue‐Ling Zhao, Qian‐Qian Ding, Si‐Ying Wang, Ting Cao, Xuan‐Ying Chen, Wu‐Cheng Tao, Shen Lin, Zhou Chen, Yi‐Xiao Luo   +11 more
wiley   +1 more source

Differential patterns of multisensory interactions in core and belt areas of human auditory cortex

, 2006
The auditory cortex is anatomically segregated into a central core and a peripheral belt region, which exhibit differences in preference to bandpassed noise and in temporal patterns of response to acoustic stimuli.
Seifritz, Erich, D. R. Bach, A. Federspiel, Herdener, M., Scheffler, Klaus, M. Herdener, Kretz, Robert, di Salle, F., Bach, Dominik R, Dierks, Thomas, Lehmann, Christoph, Herdener, Marcus, Esposito, F., Hubl, D., Esposito, Fabrizio, Hubl, Daniela, D. Hubl, Seifritz, E., Lehmann, C., Scheffler, K., Bach, D., C. Lehmann, K. Scheffler, R. Kretz, Kretz, R., T. Dierks, Dierks, T., Federspiel, Andrea, E. Seifritz, Federspiel, A., di Salle, Francesco   +30 more
core   +1 more source

Enhanced peripheral visual processing in congenitally deaf humans is supported by multiple brain regions, including primary auditory cortex

Frontiers in Human Neuroscience, 2014
Brain reorganization associated with altered sensory experience clarifies the critical role of neuroplasticity in development. An example is enhanced peripheral visual processing associated with congenital deafness, but the neural systems supporting this
Gregory D. Scott, Gregory D. Scott, Christina M Karns, Mark W. Dow, Courtney eStevens, Courtney eStevens, Helen J Neville   +6 more
doaj   +1 more source

Inhibition in the Human Auditory Cortex

PLOS ONE, 2016
Despite their indispensable roles in sensory processing, little is known about inhibitory interneurons in humans. Inhibitory postsynaptic potentials cannot be recorded non-invasively, at least in a pure form, in humans. We herein sought to clarify whether prepulse inhibition (PPI) in the auditory cortex reflected inhibition via interneurons using ...
Koji Inui, Kei Nakagawa, Makoto Nishihara, Eishi Motomura, Ryusuke Kakigi   +4 more
openaire   +4 more sources

Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS) in Glioblastoma

Advanced Science, EarlyView.
ABSTRACT Glioblastoma (GBM) remains one of the most challenging brain malignancies due to the restrictive nature of the blood–brain barrier (BBB), which severely limits effective drug and gene delivery. To overcome this, we introduce Biodegradable Acoustic Targeting for Ultrasound‐Supported Gene Therapy (BATUS), a modular platform that enables safe ...
Gulsah Erel‐Akbaba, Jinyoung Park, Achal Duhoon, Cao Thuy Giang Nguyen, Nitu Bhaskar, Sumanta Kumar Karan, Hasan Akbaba, Parbeen Singh, Thi Bao Tram Tran, Yuhui Zhu, Zhiming Li, I'jaaz Muhammad, Xiaojun Zhang, Hoang Quan Truong, A. Daniel Davidar, Elizabeth Schmitzer, Vikas N. Vattipally, Angelica F. Lopez, Patrick Kramer, Victor M. Quiroz, Ben Bykov, Claire Hao, Amir Manbachi, Nicholas Theodore, Joshua C. Doloff, Thanh D. Nguyen   +25 more
wiley   +1 more source

Robust penetrating microelectrodes for neural interfaces realized by titanium micromachining

, 2011
Neural prosthetic interfaces based upon penetrating microelectrode devices have broadened our understanding of the brain and have shown promise for restoring neurological functions lost to disease, stroke, or injury.
Patrick T. McCarthy, McCarthy, Patrick T., McCarthy, Patrick T, Rao, Masaru P, Masaru P. Rao, Kevin J. Otto, Otto, Kevin J, Rao, Masaru P., Otto, Kevin J.   +8 more
core   +2 more sources

Effect of lidocaine on salicylate-induced tinnitus in guinea pigs: A focus on the auditory cortex.

PLoS ONE
This study aimed to investigate the effects of the intravenous administration of lidocaine in the auditory cortex after the systemic administration of salicylate. Healthy male albino Hartley guinea pigs were divided into two groups.
Mutsumi Kenmochi, Kentaro Ochi, Hirotsugu Kinoshita, Shigeru Kasugai, Manabu Nakamura, Manabu Komori   +5 more
doaj   +1 more source

Multiscale Circuit Architecture Associated With Memory Dysfunction in Temporal Lobe Epilepsy

Advanced Science, EarlyView.
A multiscale precision‐mapping framework reveals that memory impairment in temporal lobe epilepsy arises from the convergence of focal medial temporal pathology, strategic white matter disconnection, and limbic‐centered metabolic network dysfunction.
Jiajie Mo, Qiwen Yuan, Pengfei Zhang, Lin Sang, Zhong Zheng, Baotian Zhao, Xiu Wang, Chao Zhang, Wenhan Hu, Xiaoqiu Shao, Jianguo Zhang, Ruijin Yang, Kai Zhang   +12 more
wiley   +1 more source