Results 41 to 50 of about 38,678 (288)

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

The Geometry of Layer 2/3 Cortical Sound Processing in Slow Wave Sleep

Advanced Science, EarlyView.
Sleep is associated with a sensory disconnection whose mechanisms remain elusive. Large neuronal population recordings in the auditory cortex revealed that, in NREM sleep, the neural code for sounds is highly similar to wakefulness, but coordinated modulations of neuron responsiveness intermittently disconnect the local cortical networks from sensory ...
Allan Muller, Anton Filipchuk, Sophie Bagur, Brice Bathellier   +3 more
wiley   +1 more source

Monitoring the Efficacy of Auditory Training through Changes in Brainstem and Cortical Auditory Evoked Potentials: A Systematic Review

The Egyptian Journal of Otolaryngology
Introduction Auditory training (AT) exercises as the main part of auditory rehabilitation have emerged as a promising method for enhancing auditory perception and communication skills in individuals with hearing impairments or difficulties in auditory ...
Ali Hajimohammadi, Fatemeh Heidari
doaj   +1 more source

Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors

Advanced Science, EarlyView.
Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen, Riya Gupta, Yosuke M. Morizawa, Yu Qin, Xingyu Du, Cynthia Pang, Osama Al‐Dalahmah, Maura B. Dupont, Guang Yang   +8 more
wiley   +1 more source

Subicular Astrocytes Govern Seizure‐Impaired Fear Memory

Advanced Science, EarlyView.
Astrocytes in dorsal subiculum act as a critical modulator of seizure‐associated cognitive dysfunction, operating through a Ca2+‐dependent adenosine‐linked astrocyte‐neuron signaling pathway that disrupts neuronal circuit homeostasis. This research highlights the potential of astrocyte‐targeted interventions as a therapeutic strategy, moving beyond the
Yuying Shao, Jing Xi, Yuhao Sun, Yulan Li, Zhisheng Li, Wangjialu Lu, Jialu Chen, Lin Yang, Fan Fei, Heming Cheng, Li Cheng, Cenglin Xu, Zhuo Huang, Vladimir Parpura, Yi Wang, Zhong Chen   +15 more
wiley   +1 more source

Multimodal evoked potentials and transcranial magnetic stimulation in diagnostics of children with encephalitis, acute disseminated encephalomyelitis and multiple sclerosis

Русский журнал детской неврологии, 2018
Background. The growing incidence of such central nervous system disorders as encephalitis (EP), acute disseminated encephalomyelitis (ADEM) and multiple sclerosis (MS) in pediatric population, similarity of their clinical manifestations at the onset ...
E. Yu. Skripchenko, A. V. Klimkin, V. B. Voitenkov, N. V. Skripchenko, A. V. Surovtseva   +4 more
doaj   +1 more source

Evaluation of N1-P2 cortical auditory evoked potential results in adult stutterers

The Egyptian Journal of Otolaryngology, 2023
Background Stuttering is a fluency disorder characterized by changes in speech flow caused by neuroaudiological factors linked to central auditory processing.
Ashraf Mahmoud Khaled, Abeir Osman Dabbous, Aisha Fawzy Abdel Hady, Dina Moustafa Abdel Sabour, Rabab Ahmed Koura   +4 more
doaj   +1 more source

XIAP Stabilizes DDRGK1 to Promote ER‐Phagy and Protects Against Noise‐Induced Hearing Loss

Advanced Science, EarlyView.
Mechanism of GAS‐mediated protection against noise‐induced hearing loss (NIHL). Noise exposure activates the ATF4/eIF2α axis, downregulating XIAP and promoting DDRGK1 degradation, thereby inhibiting ER‐phagy and leading to hair cell (HC) death. GAS treatment rescues XIAP and DDRGK1 expression, reactivating ER‐phagy to mitigate HC loss, synaptic damage,
Lin Yan, Yuhua Zhang, Jiawei Du, Yongjun Zhu, Wei Cao, Yongjie Wei, Han Wu, Shiyu Qiu, Shiyi Pan, Lian Chen, Pingping Liang, Renjie Chai, Jianming Yang, Qiaojun Fang   +13 more
wiley   +1 more source

Auditory evoked potentials in peripheral vestibular disorder individuals

International Archives of Otorhinolaryngology, 2011
Introduction: The auditory and vestibular systems are located in the same peripheral receptor, however they enter the CNS and go through different ways, thus creating a number of connections and reaching a wide area of the encephalon.
Matas, Carla Gentile, Silva, Sara Manami, Wen, Débora Dong Mei, Nunes, Cristiane da Silva, Sanches, Seisse Gabriela Gandolfi   +4 more
doaj  

Parameters for Applying the Brainstem Auditory Evoked Potential with Speech Stimulus: Systematic Review

International Archives of Otorhinolaryngology, 2017
Introduction Studies using the Brainstem Auditory Evoked Potential with speech stimulus are increasing in Brazil, and there are divergences between the methodologies used for testing. Objectives To analyze the parameters used in the study of
Luísa Bello Gabriel, Luíza Silva Vernier, Maria Inês Dornelles da Costa Ferreira, Adriana Laybauer Silveira, Márcia Salgado Machado   +4 more
doaj   +1 more source