Results 61 to 70 of about 473,597 (314)

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Benchmarking the outcomes of single-stage augmentation mastopexy against primary breast augmentation: a single surgeon's experience of 905 consecutive cases. [PDF]

, 2019
BACKGROUND Augmentation mastopexy may be performed as a one or a two-stage procedure. Due to the opposing force vectors involved in the augmentation and in mastopexy, some surgeons advocate a two-stage procedure.
Cheema, Mubashir, Hedén, Per, Wallner, Christoph, Montemurro, Paolo, Behr, Björn   +4 more
core   +1 more source

The Spectral Footprint of Neural Activity: How MUAP Properties and Spike Train Variability Shape sEMG

Bioengineering
Surface electromyographic (sEMG) signals result from the interaction between motor unit action potentials (MUAPs) and neural spike trains, yet how specific features of spike timing shape the sEMG spectrum is not fully understood.
Alvaro Costa-Garcia, Akihiko Murai
doaj   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Augmenting Kashgar

2014 International Conference on Virtual Systems & Multimedia (VSMM), 2014
© 2014 IEEE.This paper demonstrates a framework for a digital heritage research, Augmenting Kashgar, that facilitates the revitalizing of a historical architecture by using gamification, shape grammars and virtual reality. Examining current use of new media technologies, our methodology initially merges shape grammars, a generative modelling method ...
Serdar Aydin, Marc Aurel Schnabel
openaire   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Cloud-based augmentation for mobile devices: Motivation, taxonomies, and open challenges [PDF]

, 2013
Recently, Cloud-based Mobile Augmentation (CMA) approaches have gained remarkable ground from academia and industry. CMA is the state-of-the-art mobile augmentation model that employs resource-rich clouds to increase, enhance, and optimize computing ...
Zohreh Sanaei, Rajkumar Buyya, Ejaz Ahmed, Sanaei, Zohreh, Buyya, Rajkumar, Saeid Abolfazli, Gani, Abdullah, Ahmed, Ejaz, Abdullah Gani, Abolfazli, Saeid   +9 more
core   +1 more source

Transforming informal communication in the urgent shift to teleworking: a case study in Japan

Frontiers in Communication
IntroductionWhile informal communication is essential for employee performance and wellbeing, it is difficult to maintain in telework settings. This issue has recently been becoming more prominent worldwide, especially because of the coronavirus disease ...
Kentaro Watanabe, Hiroyuki Umemura, Ikue Mori, Saya Amemiya, Yuji Yamamoto   +4 more
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source