Results 31 to 40 of about 87,351 (255)

Atypical Antipsychotics as Augmentation Therapy in Anorexia Nervosa [PDF]

PLOS ONE, 2015
Anorexia nervosa (AN) is a life-threatening and difficult to treat mental illness with the highest mortality rates of any psychiatric disorder. We aimed to garner preliminary data on the real-world use of olanzapine and aripiprazole as augmentation agents of Selective Serotonin Reuptake Inhibitors (SSRIs) in adult inpatients affected by AN.
MARZOLA, ENRICA, Desedime, Nadia, GIOVANNONE, Maria Cristina, AMIANTO, Federico, FASSINO, Secondo, ABBATE DAGA, Giovanni   +5 more
openaire   +4 more sources

Alpha-1 Antitrypsin Augmentation Therapy Improves Survival in Severely Deficient Patients with Predicted FEV1 Between 10% and 60%: A Retrospective Analysis of the NHLBI Alpha-1 Antitrypsin Deficiency Registry

International Journal of COPD, 2020
Franck F Rahaghi,1 Richard Monk,2 Viswanathan Ramakrishnan,3 Tatsiana Beiko,2 Charlie Strange2 1Department of Pulmonary and Critical Care, Cleveland Clinic Florida, Weston, FL, USA; 2Division of Pulmonary, Critical Care, Allergy and Sleep Medicine ...
Rahaghi FF, Monk R, Ramakrishnan V, Beiko T, Strange C   +4 more
doaj  

Recommendations for the Implementation of the Self-Administration of Alpha-1 Antitrypsin

International Journal of COPD, 2023
María Torres-Durán,1 José Luis López-Campos,2,3 Myriam Calle Rubio,4 Carmen Montero-Martínez,5 Ana Priegue Carrera,6 Rosanel Amaro Rodríguez,7 Miriam Barrecheguren,8 María Ángeles Barrio Guirado,9 Francisco Javier Callejas-González,10 Francisco Casas ...
Torres-Durán M, López-Campos JL, Calle Rubio M, Montero-Martínez C, Priegue Carrera A, Amaro Rodríguez R, Barrecheguren M, Barrio Guirado MA, Callejas-González FJ, Casas-Maldonado F, Diab-Cáceres L, García-Meseguer P, Hernández-Pérez JM, Lázaro-Asegurado L, Martínez-González C, Martínez Rivera C, Michel FJ, Montoro-Ronsano JB, Sánchez R, Ortiz-Pica M, Parra I, Quintero García JP, Ruiz-Serrano-de la Espada MDR, Tortajada-Goitia B, Miravitlles M   +24 more
doaj  

Restless legs syndrome augmentation among Japanese patients receiving pramipexole therapy: Rate and risk factors in a retrospective study. [PDF]

PLoS ONE, 2017
To investigate the rate of and risk factors for restless legs syndrome (RLS) augmentation in Japanese patients receiving pramipexole (PPX) treatment. Records of 231 consecutive patients with idiopathic RLS who received PPX therapy for more than one month
Masayoshi Takahashi, Shingo Nishida, Masaki Nakamura, Mina Kobayashi, Kentaro Matsui, Eiki Ito, Akira Usui, Yuichi Inoue   +7 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Sustained high expression of human FVII following AAV8-mediated gene delivery in mice

Molecular Therapy: Methods & Clinical Development
Factor VII (FVII) deficiency is a rare bleeding disorder with a prevalence of approximately 1:300,000–500,000 individuals. We explored whether adeno-associated virus (AAV)-mediated gene therapy can achieve durable and functional expression of human FVII (
Andrea D’Amico, Bas Blits, Joëlle van den Herik, Fred de Winter, Paul H.P. Kaijen, Barbara Hobo, Alexander Henrik van Asbeck, Joost Verhaagen, David G.M. Mosmuller, Jan Voorberg   +9 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Phenotypic Expression of Respiratory Diseases and Tailored Treatment in Patients with Intermediate Alpha-1 Antitrypsin Deficiency: Evidence from a Retrospective Analysis of a Selected Cohort of Patients

Medicina
Introduction: Alpha-1 antitrypsin deficiency (AATD) is a genetic condition caused by SERPINA1 variants with variable severity. Current international guidelines do not recommend augmentation therapy for intermediate AATD; nevertheless, some patients show ...
Anna Annunziata, Giuseppe Fiorentino, Francesca Simioli, Lidia Atripaldi, Marco Balestrino, Giacomo Zuccarini, Barbara Piras, Alessandro Libra, Fabio Pino, Pierpaolo Di Micco, Carmine Siniscalchi, Ilaria Ferrarotti, Luigi Aronne, Raffaella Manzo, Carlo Vancheri, Cecilia Calabrese   +15 more
doaj   +1 more source

Mitochondrial translation and coordinated cytosolic translation in metabolic homeostasis and disease

FEBS Letters, EarlyView.
Mitochondrial function depends on coordinated protein production from the nuclear and mitochondrial genomes. This review highlights how cytosolic and mitochondrial translation, mRNA localization, protein import, and respiratory complex assembly are integrated to maintain mitochondrial proteostasis and function.
Boseon Kim, Thi Thanh Mai Tran, Nakyung Kang, Min‐Woo Lee, Mihye Lee   +4 more
wiley   +1 more source

Efficacy of alpha1-antitrypsin augmentation therapy in conditions other than pulmonary emphysema

Orphanet Journal of Rare Diseases, 2011
Up to now alpha 1-antitrypsin (AAT) augmentation therapy has been approved only for commercial use in selected adults with severe AAT deficiency-related pulmonary emphysema (i.e.
de Serres Frederick, Lara Beatriz, Blanco Ignacio   +2 more
doaj   +1 more source