Results 1 to 10 of about 97,184 (241)

CT-defined Emphysema Morphology as a Predictor for Histological Subtypes of Lung Cancer: A Single-center Retrospective Study [PDF]

Thoracic Research and Practice
OBJECTIVE: Lung cancer and pulmonary emphysema share common risk factors and pathophysiological pathways. Emerging evidence suggests that emphysema morphology, rather than emphysema burden, may influence lung cancer histology.
Fadlan Adima Adrianta, Dini Rachma Erawati, Suryanti Dwi Pratiwi, Nanik Setijowati   +3 more
doaj   +2 more sources

Tropomyosin 2.1 collaborates with fibronectin to promote TGF-β1-induced contraction of human lung fibroblasts

Respiratory Research, 2021
Many lung diseases are characterized by fibrosis, leading to impaired tissue patency and reduced lung function. Development of fibrotic tissue depends on two-way interaction between the cells and the extra-cellular matrix (ECM).
Peta Bradbury, Cassandra P. Nader, Aylin Cidem, Sandra Rutting, Dianne Sylvester, Patrick He, Maria C. Rezcallah, Geraldine M. O’Neill, Alaina J. Ammit   +8 more
doaj   +1 more source

Ninjurin1 drives lung tumor formation and progression by potentiating Wnt/β-Catenin signaling through Frizzled2-LRP6 assembly

Journal of Experimental & Clinical Cancer Research, 2022
Background Cancer stem-like cells (CSCs) play a pivotal role in lung tumor formation and progression. Nerve injury-induced protein 1 (Ninjurin1, Ninj1) has been implicated in lung cancer; however, the pathological role of Ninj1 in the context of lung ...
Seung Yeob Hyun, Hye-Young Min, Ho Jin Lee, Jaebeom Cho, Hye-Jin Boo, Myungkyung Noh, Hyun-Ji Jang, Hyo-Jong Lee, Choon-Sik Park, Jong-Sook Park, Young Kee Shin, Ho-Young Lee   +11 more
doaj   +1 more source

Isolation of slow-cycling cancer cells from lung patient-derived xenograft using carboxyfluorescein-succinimidyl ester retention-mediated cell sorting

STAR Protocols, 2023
Summary: The slow-cycling subpopulation plays an important role in anticancer drug resistance and tumor recurrence. Here, we describe a clinically relevant patient-derived xenograft model and a carboxyfluorescein succinimidyl ester dye that is diluted in
Jaebeom Cho, Hye-Young Min, Ho-Young Lee
doaj   +1 more source

Prognostic significance of tumor microenvironment assessed by machine learning algorithm in surgically resected non‐small cell lung cancer

Cancer Reports, EarlyView., 2023
Abstract Background A methodology to assess the immune microenvironment (IME) of non‐small cell lung cancer (NSCLC) has not been established, and the prognostic impact of IME factors is not yet clear. Aims This study aimed to assess the IME factors and evaluate their prognostic values. Methods and Results We assessed CD8+ tumor‐infiltrating lymphocyte (
Yukihiro Terada, Mitsuhiro Isaka, Akira Ono, Takuya Kawata, Masakuni Serizawa, Keita Mori, Koji Muramatsu, Kiyoshi Tone, Hirotsugu Kenmotsu, Keiichi Ohshima, Kenichi Urakami, Takeshi Nagashima, Masatoshi Kusuhara, Yasuto Akiyama, Takashi Sugino, Toshiaki Takahashi, Yasuhisa Ohde   +16 more
wiley   +1 more source

Regulation of ATP binding cassette transporter A1 (ABCA1) expression: cholesterol-dependent and – independent signaling pathways with relevance to inflammatory lung disease

Respiratory Research, 2020
The role of the ATP binding cassette transporter A1 (ABCA1) in maintaining cellular lipid homeostasis in cardiovascular disease is well established. More recently, the important beneficial role played by ABCA1 in modulating pathogenic disease mechanisms,
Patrick He, Ingrid C. Gelissen, Alaina J. Ammit   +2 more
doaj   +1 more source

Emphysema Is Common in Lungs of Cystic Fibrosis Lung Transplantation Patients: A Histopathological and Computed Tomography Study. [PDF]

PLoS ONE, 2015
Lung disease in cystic fibrosis (CF) involves excessive inflammation, repetitive infections and development of bronchiectasis. Recently, literature on emphysema in CF has emerged, which might become an increasingly important disease component due to the ...
Onno M Mets, Suzan M Roothaan, Inez Bronsveld, Bart Luijk, Ed A van de Graaf, Aryan Vink, Pim A de Jong   +6 more
doaj   +1 more source

Protein phosphatase 2A (PP2A): a key phosphatase in the progression of chronic obstructive pulmonary disease (COPD) to lung cancer

Respiratory Research, 2019
Lung cancer (LC) has the highest relative risk of development as a comorbidity of chronic obstructive pulmonary disease (COPD). The molecular mechanisms that mediate chronic inflammation and lung function impairment in COPD have been identified in LC ...
Cassandra P. Nader, Aylin Cidem, Nicole M. Verrills, Alaina J. Ammit   +3 more
doaj   +1 more source

Emphysema Distribution and Diffusion Capacity Predict Emphysema Progression in Human Immunodeficiency Virus Infection. [PDF]

PLoS ONE, 2016
Chronic obstructive pulmonary disease (COPD) and emphysema are common amongst patients with human immunodeficiency virus (HIV). We sought to determine the clinical factors that are associated with emphysema progression in HIV.345 HIV-infected patients ...
Janice M Leung, Andrea Malagoli, Antonella Santoro, Giulia Besutti, Guido Ligabue, Riccardo Scaglioni, Darlene Dai, Cameron Hague, Jonathon Leipsic, Don D Sin, Sf Paul Man, Giovanni Guaraldi   +11 more
doaj   +1 more source

Comparison Of Artificial Intelligence-Based Chest CT Emphysema Quantification to Pulmonary Function Tests [PDF]

Ain Shams Medical Journal, 2023
Background: Chronic obstructive pulmonary disease is caused by small-airway disease and emphysema. Although pulmonary function tests (PFT) measure airflow obstruction, they can't differentiate between airflow limitation and emphysema. Computed Tomography
Sarah Isaac, Ahmed Mohamed, Sherif Abbas, Marwa Daif   +3 more
doaj   +1 more source