Results 1 to 10 of about 101,268 (117)

Emphysema severity-associated gut microbiota modulates smoke-induced emphysema: evidence from fecal microbiota transplantation [PDF]

open access: yesRespiratory Research
Background Cigarette smoking is the key risk factor for chronic obstructive pulmonary disease, but even similar levels of smoking can result in different disease severity.
Na Hyun Kim   +16 more
doaj   +2 more sources

Imaging of pulmonary emphysema: A pictorial review

open access: yesInternational Journal of COPD, 2008
Masashi Takahashi1, Junya Fukuoka2, Norihisa Nitta1, Ryutaro Takazakura1, Yukihiro Nagatani1, Yoko Murakami1, Hideji Otani1, Kiyoshi Murata11Department of Radiology, Shiga University of Medical Science, Shiga, Japan; 2Laboratory of Pathology, Toyama ...
Yukihiro Nagatani   +2 more
exaly   +2 more sources

Tropomyosin 2.1 collaborates with fibronectin to promote TGF-β1-induced contraction of human lung fibroblasts

open access: yesRespiratory Research, 2021
Many lung diseases are characterized by fibrosis, leading to impaired tissue patency and reduced lung function. Development of fibrotic tissue depends on two-way interaction between the cells and the extra-cellular matrix (ECM).
Peta Bradbury   +8 more
doaj   +1 more source

Ninjurin1 drives lung tumor formation and progression by potentiating Wnt/β-Catenin signaling through Frizzled2-LRP6 assembly

open access: yesJournal of Experimental & Clinical Cancer Research, 2022
Background Cancer stem-like cells (CSCs) play a pivotal role in lung tumor formation and progression. Nerve injury-induced protein 1 (Ninjurin1, Ninj1) has been implicated in lung cancer; however, the pathological role of Ninj1 in the context of lung ...
Seung Yeob Hyun   +11 more
doaj   +1 more source

Isolation of slow-cycling cancer cells from lung patient-derived xenograft using carboxyfluorescein-succinimidyl ester retention-mediated cell sorting

open access: yesSTAR Protocols, 2023
Summary: The slow-cycling subpopulation plays an important role in anticancer drug resistance and tumor recurrence. Here, we describe a clinically relevant patient-derived xenograft model and a carboxyfluorescein succinimidyl ester dye that is diluted in
Jaebeom Cho, Hye-Young Min, Ho-Young Lee
doaj   +1 more source

Regulation of ATP binding cassette transporter A1 (ABCA1) expression: cholesterol-dependent and – independent signaling pathways with relevance to inflammatory lung disease

open access: yesRespiratory Research, 2020
The role of the ATP binding cassette transporter A1 (ABCA1) in maintaining cellular lipid homeostasis in cardiovascular disease is well established. More recently, the important beneficial role played by ABCA1 in modulating pathogenic disease mechanisms,
Patrick He   +2 more
doaj   +1 more source

Emphysema Is Common in Lungs of Cystic Fibrosis Lung Transplantation Patients: A Histopathological and Computed Tomography Study. [PDF]

open access: yesPLoS ONE, 2015
Lung disease in cystic fibrosis (CF) involves excessive inflammation, repetitive infections and development of bronchiectasis. Recently, literature on emphysema in CF has emerged, which might become an increasingly important disease component due to the ...
Onno M Mets   +6 more
doaj   +1 more source

Protein phosphatase 2A (PP2A): a key phosphatase in the progression of chronic obstructive pulmonary disease (COPD) to lung cancer

open access: yesRespiratory Research, 2019
Lung cancer (LC) has the highest relative risk of development as a comorbidity of chronic obstructive pulmonary disease (COPD). The molecular mechanisms that mediate chronic inflammation and lung function impairment in COPD have been identified in LC ...
Cassandra P. Nader   +3 more
doaj   +1 more source

Emphysema Distribution and Diffusion Capacity Predict Emphysema Progression in Human Immunodeficiency Virus Infection. [PDF]

open access: yesPLoS ONE, 2016
Chronic obstructive pulmonary disease (COPD) and emphysema are common amongst patients with human immunodeficiency virus (HIV). We sought to determine the clinical factors that are associated with emphysema progression in HIV.345 HIV-infected patients ...
Janice M Leung   +11 more
doaj   +1 more source

Comparison Of Artificial Intelligence-Based Chest CT Emphysema Quantification to Pulmonary Function Tests [PDF]

open access: yesAin Shams Medical Journal, 2023
Background: Chronic obstructive pulmonary disease is caused by small-airway disease and emphysema. Although pulmonary function tests (PFT) measure airflow obstruction, they can't differentiate between airflow limitation and emphysema. Computed Tomography
Sarah Isaac   +3 more
doaj   +1 more source

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