Results 11 to 20 of about 97,184 (241)

Eosinophils promote pulmonary matrix destruction and emphysema via Cathepsin L

open access: yesSignal Transduction and Targeted Therapy, 2023
Patients with chronic obstructive pulmonary disease (COPD) who exhibit elevated blood eosinophil levels often experience worsened lung function and more severe emphysema.
Xia Xu   +14 more
doaj   +1 more source

Association Between Air Pollution and Lung Lobar Emphysema in COPD

open access: yesFrontiers in Medicine, 2021
The development of emphysema has been linked to air pollution; however, the association of air pollution with the extent of lobar emphysema remains unclear.
Nguyen Thanh Tung   +22 more
doaj   +1 more source

CT Assessment of Subtypes of Pulmonary Emphysema in Mongolian Miners

open access: yesCentral Asian Journal of Medical Sciences, 2020
Objectives: To determine the incidence of subtypes of pulmonary emphysema identified by LDCT imaging and the relationship between emphysema subtypes with smoking and pulmonary function in miners.
Garamjav Khishigdavaa   +7 more
doaj   +1 more source

A circadian based inflammatory response – implications for respiratory disease and treatment

open access: yesSleep Science and Practice, 2017
Circadian clocks regulate the daily timing of many of our physiological, metabolic and biochemical functions. The immune system also displays circadian oscillations in immune cell count, synthesis and cytokine release, clock gene expression in cells and ...
Maria Comas   +8 more
doaj   +1 more source

Development of a 4-aminopyrazolo[3,4-d]pyrimidine-based dual IGF1R/Src inhibitor as a novel anticancer agent with minimal toxicity

open access: yesMolecular Cancer, 2018
Background Both the type I insulin-like growth factor receptor (IGF1R) and Src pathways are associated with the development and progression of numerous types of human cancer, and Src activation confers resistance to anti-IGF1R therapies. Hence, targeting
Ho Jin Lee   +8 more
doaj   +1 more source

Pulmonary Emphysema: Visual Interpretation and Quantitative Analysis

open access: yes대한영상의학회지, 2021
Pulmonary emphysema is a cause of chronic obstructive pulmonary disease. Emphysema can be accurately diagnosed via CT. The severity of emphysema can be assessed using visual interpretation or quantitative analysis.
Jihang Kim
doaj   +1 more source

Association between plasma sRAGE and emphysema according to the genotypes of AGER gene

open access: yesBMC Pulmonary Medicine, 2022
Background Higher soluble receptor for advanced glycation end product (sRAGE) levels are considered to be associated with severe emphysema. However, the relationship remains uncertain when the advanced glycation end-product specific receptor (AGER) gene ...
Sooim Sin   +4 more
doaj   +1 more source

S100A14: A novel negative regulator of cancer stemness and immune evasion by inhibiting STAT3‐mediated programmed death‐ligand 1 expression in colorectal cancer

open access: yesClinical and Translational Medicine, 2022
Background Programmed death‐ligand 1 (PD‐L1) has functional roles in cancer stem‐like cell (CSC) phenotypes and chemoresistance besides immune evasion.
Hye‐Young Min   +14 more
doaj   +1 more source

Basilar Predominant Emphysema: Thinking beyond Alpha-1-Antitrypsin Deficiency

open access: yesCase Reports in Medicine, 2022
Basilar predominant emphysema, or disproportionate emphysematous involvement of the lung bases compared to the apices, is an uncommon radiographic pattern of emphysema traditionally associated with alpha-1-antitrypsin deficiency (AATD). We present a case
Ho-Man Yeung, Lauren Gaffaney
doaj   +1 more source

Surgery for emphysema [PDF]

open access: yesBMJ, 2006
Emphysema affects 3.1 million people in the United States alone and causes severe disability and early death in up to 45% of patients.1 Emphysematous destruction of the lung is associated with decreased elastic recoil pressure. As a result, the diseased lung requires less pressure than a normal lung to inflate and, once inflated, exerts less pressure ...
VENUTA, Federico, G. Bognolo
openaire   +2 more sources

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