Results 31 to 40 of about 124,570 (215)

Beyond Visual Scoring: Computational Computed Tomography Analysis for High‐Resolution Computed Tomography–Based Quantification of Interstitial Lung Disease in Inflammatory Rheumatic Disease

Arthritis Care &Research, EarlyView.
Interstitial lung disease (ILD) is a significant cause of morbidity and mortality in patients with inflammatory rheumatic disorders (IRDs). High‐resolution computed tomography (HRCT) is widely considered the gold standard for the noninvasive assessment of ILD; however, its interpretation is constrained by substantial interobserver variability and the ...
Alexander Pfeil, Tobias Hoffmann, Ulf Teichgräber, Diane Renz, Denise Beckmann, Gunter Wolf, Nicole Schadewaldt, Bianca Lassen‐Schmidt   +7 more
wiley   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

The impact of emphysema on surgical outcomes of early-stage lung cancer: a retrospective study

BMC Pulmonary Medicine, 2019
Background The presence of emphysema on computed tomography (CT) is associated with an increased frequency of lung cancer, but the postoperative outcomes of patients with pulmonary emphysema are not well known.
Seijiro Sato, Masaya Nakamura, Yuki Shimizu, Tatsuya Goto, Terumoto Koike, Hiroyuki Ishikawa, Masanori Tsuchida   +6 more
doaj   +1 more source

Mortality in combined pulmonary fibrosis and emphysema patients is determined by the sum of pulmonary fibrosis and emphysema [PDF]

, 2021
In patients with combined pulmonary fibrosis and emphysema, emphysema and fibrosis do not have a synergistic effect that results in worsened survival when compared to IPF patients without emphysema https://bit.ly ...
Wells, AU, Mogulkoc, Nesrin, Savas, R, Taliani, A, Gholipour, Bahareh, Moodley, Yuben, Taliani, Alessandro, Alexander, DC, Jo, H, Brereton, CJ, Gholipour, B, Jones, Mark G, Annalisa De Liperi, Hopkins, P, Alessandro Taliani, van Es, Hendrik W, Janes, S, Eyjolfur Gudmundsson, Wells, Athol U, Iain Stewart, Nesrin Mogulkoc, Helen Jo, Frouke van Beek, Tavanti, Laura, Unat, O, Yuben Moodley, Sam Janes, Mogulkoc, N, Zhao, A, David Barber, De Liperi, Annalisa, Unat, Omer, Pontoppidan, Katarina, Recep Savas, Hendrik W. van Es, De Liperi, A, Gudmundsson, Eyjolfur, Van Moorsel, C, Gudmundsson, E, Coline van Moorsel, Romei, Chiara, Tamera J. Corte, Nair, Arjun, Corte, Tamera J, Stewart, Iain, Nair, A, Jacob, J, Laura Tavanti, Arjun Nair, Jones, MG, Van Es, HW, Christopher J. Brereton, Omer Unat, Katarina Pontoppidan, Romei, C, Chiara Romei, Barber, David, Peter Hopkins, Zhao, An, Mark G. Jones, Marcel Veltkamp, van Beek, Frouke, Bahareh Gholipour, Daniel C. Alexander, Pontoppidan, K, Tavanti, L, Veltkamp, Marcel, Jacob, Joseph, van Moorsel, Coline, Hopkins, Peter, Veltkamp, M, Savas, Recep, Jo, Helen, Brereton, Christopher J, Corte, TJ, Van Beek, F, Joseph Jacob, Athol U. Wells, Barber, D, Stewart, I, An Zhao, Alexander, Daniel C, Moodley, Y, Janes, Sam, Jones, Mark G., Corte, Tamera J.   +85 more
core   +1 more source

Microfluidic Gratings for X‐Ray Phase Contrast Imaging

Advanced Science, EarlyView.
This work establishes a new protocol for the fabrication of X‐ray gratings that exploits the advantages of microfluidics and enables a more inexpensive, faster, and scalable production process. These X‐ray devices are fundamental for implementing X‐ray phase contrast imaging (XPCI) in laboratory and clinical settings, yet their costly and complex ...
Alessandro Rossi, Antonio Ferraro, Francesco Coccimiglio, Tiziana Ritacco, Alberto Astolfo, Michele Giocondo, Vincenzo Formoso, Raffaele Giuseppe Agostino, Francesco Iacoviello, Ioannis Papakonstantinou, Alessandro Olivo   +10 more
wiley   +1 more source

A General High‐Throughput Mucus Microrheology Platform for Quantitative and Scalable Mucus Phenotyping

Advanced Science, EarlyView.
High‐throughput Differential Dynamic Microscopy measures frequency‐resolved mechanical fingerprints from 3 to 10 μL$\umu{\rm L}$ mucus samples using only a few minutes of operator attention per sample. This automated analysis enables scalable mucus phenotyping for translational research by distinguishing mechanical heterogeneity among donors, disease ...
Feng Ling, Ayşe Tuğçe Şahin, Bernardo Miller Naranjo, Stefano Aime, Doris Roth, Anna Pukaluk, Niels Tepho, Romina Augustin, Benedetta Zampa, Andrea S. Vendrame, Mark‐Christian Klassen, Ellen Emken, Marion Kiechle, Mircea Gabriel Stoleriu, Pontus Mertsch, Ruth Olmer, Yohannes Tesfaigzi, Oliver Lieleg, Janna C. Nawroth   +18 more
wiley   +1 more source

Localized Pulmonary Interstitial Emphysema Which Occurred After Non-invasive Mechanical Ventilatory Support

, 2020
Pulmonary interstitial emphysema is a rare condition characterized by collection of air in the pulmonary interstitial tissue outside normal air passages as a result of injury to the alveoli and small airways, and accumulation of air within the ...
Hakan Ildır, Sevgi Pekcan, Abdullah Yazar, Esra Türe, Fatih Akın, TÜRE, ESRA, ILDIR, HAKAN, YAZAR, ABDULLAH, AKIN, FATİH, PEKCAN, SEVGİ   +9 more
core   +1 more source

ACAT1‐Mediated SP1‐K694 Lactylation Promotes M1 Macrophage Polarization via TREM1 Transcription in COPD

Advanced Science, EarlyView.
Upon cigarette smoke exposure(CSE), LDHA expression is increased in lung macrophages, promoting the conversion of pyruvate to lactate and elevating the lactylation level of SP1 at the K694 site. This, in turn, enhances SP1 enrichment at the TREM1 promoter, increases TREM1 expression, promoted M1 macrophage polarization, and triggers the secretion of ...
Ling Lin, Ping Zhang, Qing Song, Tao Li, Yuqin Zeng, Ping Chen   +5 more
wiley   +1 more source

Autocrine insulin-like growth factor 2 signaling as a potential target in the associated development of pulmonary emphysema and cancer in smokers

Inflammation and Regeneration
Background Tobacco smoking causes pulmonary inflammation, resulting in emphysema, an independent risk factor for lung cancer. Induction of insulin-like growth factor 2 (IGF2) in response to lung injury by tobacco carcinogens, 4-(methylnitrosamino)-1-(3 ...
Hye-Jin Boo, Hye-Young Min, Heung-Bin Lim, Euni Lee, Ho-Young Lee   +4 more
doaj   +1 more source

Animal models of emphysema

Chinese Medical Journal, 2019
. Objective. Chronic obstructive pulmonary disease (COPD) is a common chronic respiratory disease of human beings characterized by not fully reversible airflow limitation.
Gui-Bin Liang, Zhi-Hui He, Xin Chen
doaj   +1 more source