Results 31 to 40 of about 122,393 (245)

Effects of Lung Volume Reduction Surgery on Gas Exchange and Breathing Pattern During Maximum Exercise [PDF]

, 2008
Background: The National Emphysema Treatment Trial studied lung volume reduction surgery (LVRS) for its effects on gas exchange, breathing pattern, and dyspnea during exercise in severe emphysema.
Criner, Gerard J., Belt, Patricia, Sternberg, Alice L., Sciurba, Frank C., Mosenifar, Zab, Utz, James P., Make, Barry J.   +6 more
core   +1 more source

S100A14: A novel negative regulator of cancer stemness and immune evasion by inhibiting STAT3‐mediated programmed death‐ligand 1 expression in colorectal cancer

Clinical and Translational Medicine, 2022
Background Programmed death‐ligand 1 (PD‐L1) has functional roles in cancer stem‐like cell (CSC) phenotypes and chemoresistance besides immune evasion.
Hye‐Young Min, Jaebeom Cho, Jeong Yeon Sim, Hye‐Jin Boo, Ji‐Sun Lee, Seon‐Boon Lee, Young‐Jin Lee, Sung Joo Kim, Kyu‐Pyo Kim, In‐Ja Park, Seung‐Mo Hong, Xue‐Li Zhang, Zhi‐Gang Zhang, Rang‐Woon Park, Ho‐Young Lee   +14 more
doaj   +1 more source

The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells

Nature Communications, 2016
The binding of tobacco-specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) to nicotinic acetylcholine receptors (nAChRs) induces calcium signalling.
Hye-Jin Boo, Hye-Young Min, Hyun-Ji Jang, Hye Jeong Yun, John Kendal Smith, Quanri Jin, Hyo-Jong Lee, Diane Liu, Hee-Seok Kweon, Carmen Behrens, J. Jack Lee, Ignacio I. Wistuba, Euni Lee, Waun Ki Hong, Ho-Young Lee   +14 more
doaj   +1 more source

Basilar Predominant Emphysema: Thinking beyond Alpha-1-Antitrypsin Deficiency

Case Reports in Medicine, 2022
Basilar predominant emphysema, or disproportionate emphysematous involvement of the lung bases compared to the apices, is an uncommon radiographic pattern of emphysema traditionally associated with alpha-1-antitrypsin deficiency (AATD). We present a case
Ho-Man Yeung, Lauren Gaffaney
doaj   +1 more source

Polymers and inflammation: disease mechanisms of the serpinopathies [PDF]

, 2008
Members of the serpin (serine proteinase inhibitor) superfamily play a central role in the control of inflammatory, coagulation, and fibrinolytic cascades.
David A. Lomas, Lomas, D.A., Gooptu, Bibek, Bibek Gooptu, Gooptu, Bibekbrata   +4 more
core   +1 more source

Differentiating Smoking-Related Interstitial Fibrosis (SRIF) from Usual Interstitial Pneumonia (UIP) with Emphysema Using CT Features Based on Pathologically Proven Cases. [PDF]

PLoS ONE, 2016
To differentiate smoking-related interstitial fibrosis (SRIF) from usual interstitial pneumonia (UIP) with emphysema on CT in combined pulmonary fibrosis and emphysema (CPFE) patients.This study was approved by the institutional review board and informed
Kum Ju Chae, Gong Yong Jin, Hyun Nyeong Jung, Keun Sang Kwon, Hyemi Choi, Yong Chul Lee, Myoung Ja Chung, Ho Sung Park   +7 more
doaj   +1 more source

Management of Massive Post-Tracheostomy Subcutaneous Emphysema With an Adjustable-Length, Wire-Reinforced Tracheostomy Tube: A Case Report. [PDF]

Clin Case Rep
ABSTRACT Massive subcutaneous emphysema with pneumomediastinum is a rare but potentially life‐threatening complication following tracheostomy, for which standardized management strategies are lacking. We report the case of a 67‐year‐old man who developed progressive cervicofacial and thoracic subcutaneous emphysema on postoperative Day 9 after an ...
Aboul Hosn O, Khattar R, Hadi JA, Dunya G, Melki SJ.   +4 more
europepmc   +2 more sources

Beyond Visual Scoring: Computational Computed Tomography Analysis for High‐Resolution Computed Tomography–Based Quantification of Interstitial Lung Disease in Inflammatory Rheumatic Disease

Arthritis Care &Research, EarlyView.
Interstitial lung disease (ILD) is a significant cause of morbidity and mortality in patients with inflammatory rheumatic disorders (IRDs). High‐resolution computed tomography (HRCT) is widely considered the gold standard for the noninvasive assessment of ILD; however, its interpretation is constrained by substantial interobserver variability and the ...
Alexander Pfeil, Tobias Hoffmann, Ulf Teichgräber, Diane Renz, Denise Beckmann, Gunter Wolf, Nicole Schadewaldt, Bianca Lassen‐Schmidt   +7 more
wiley   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

The impact of emphysema on surgical outcomes of early-stage lung cancer: a retrospective study

BMC Pulmonary Medicine, 2019
Background The presence of emphysema on computed tomography (CT) is associated with an increased frequency of lung cancer, but the postoperative outcomes of patients with pulmonary emphysema are not well known.
Seijiro Sato, Masaya Nakamura, Yuki Shimizu, Tatsuya Goto, Terumoto Koike, Hiroyuki Ishikawa, Masanori Tsuchida   +6 more
doaj   +1 more source