Results 171 to 180 of about 177,414 (289)

Self-administration of augmentation therapy for alpha 1-antitrypsin deficiency. [PDF]

IJTLD Open
Vianello A, Lococo S, Corda L, Torrazza M, Zuccarini G, Baderna P, Cinetto F, Bargagli E, Confalonieri P, Sanduzzi Zamparelli S, Bertagna De Marchi L, Molena B, Lionello F, Caminati M, Guarnieri G.   +14 more
europepmc   +1 more source

Fine-tuning FAM161A gene augmentation therapy to restore retinal function

, 2023
Arsenijevic Y, Chang N, Mercey O, Fersioui YE, Koskiniemi-Kuendig H, Joubert C, Bemelmans A, Rivolta C, Banin E, Sharon D, Guichard P, Hamel V, Kostic C.   +12 more
europepmc   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Amisulpride augmentation therapy improves cognitive performance and psychopathology in clozapine-resistant treatment-refractory schizophrenia: a 12-week randomized, double-blind, placebo-controlled trial. [PDF]

Mil Med Res, 2022
Zhu MH, Liu ZJ, Hu QY, Yang JY, Jin Y, Zhu N, Huang Y, Shi DH, Liu MJ, Tan HY, Zhao L, Lv QY, Yi ZH, Wu FC, Li ZZ.   +14 more
europepmc   +1 more source

Combined kidney/bone marrow transplantation — Evidence of augmentation of chimerism [PDF]

, 1995
Carroll, P, Demetris, AJ, Fontes, P, Jordan, M, Rao, AS, Rybka, W, Scantlebury, VP, Shapiro, R, Starzl, TE, Trucco, M, Vivas, C, Zeevi, A   +11 more
core   +1 more source

Improved Systemic Immunochemotherapy Employing an Oxaliplatin‐TLR7/8 Agonist Prodrug Strategy

Advanced Science, EarlyView.
A platinum(IV) prodrug is developed to systemically deliver the TLR7/8 agonist gardiquimod. Tumor‐targeting is mediated by an albumin‐binding maleimide, which limits premature complex activation. Ox‐Gardi‐Mal accumulates specifically in the tumor, where it activates the immune system.
Michael Gutmann, Martijn Dijkstra, Philipp Salomon, Jamie Cowles, Anja Federa, Dina Baier, Carola Jaunecker, Iemima Semerean, Venla Karvonen, Christine Pirker, Maria Sibilia, Dietmar Herndler‐Brandstetter, Petra Heffeter, Bernhard K. Keppler, Christian R. Kowol, Walter Berger   +15 more
wiley   +1 more source

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Corrigendum to: Long-term experience with gene augmentation therapy in patients with inherited retinal disease associated with biallelic mutations in RPE65. [PDF]

Med Genet
Lorenz B.
europepmc   +1 more source

Kidney transplantation with bone marrow augmentation: Five-year outcomes [PDF]

, 2001
A Jain, A Zeevi, A.S Rao, Barber, C.A Vivas, Ciancio, Ciancio, Corry, E.A Gray, Fontes, Garcia-Morales, I Dvorchik, J McCauley, J McMichael, J.J Fung, M Valenti, M.L Jordan, McDaniel, Miller, Monaco, Monaco, P Randhawa, Quesenberry, R Shapiro, R.J Corry, Rao, Shapiro, Shapiro, Shapiro, Shapiro, Spitzer, T.E Starzl, V.P Scantlebury   +32 more
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source