Results 61 to 70 of about 142,807 (311)

Targeted Extracellular Vesicles Deliver Asiaticoside to Inhibit AURKB/DRP1‐Mediated Mitochondrial Fission and Attenuate Hypertrophic Scar Formation

Advanced Science, EarlyView.
Hypertrophic scar formation is driven by excessive mitochondrial fission in wound macrophages, which we discover is governed by a novel AURKB‐DRP1(Ser616) axis. The study develops a targeted therapy using cRGD‐decorated extracellular vesicles to deliver the natural compound Asiaticoside specifically to macrophages.
Luyu Li, Chenli Si, Xue Wang, Xiaojin Wu, Ying Shang, Shengfang Ge, Yong Wang, Yong Zuo, Zhen Zhang   +8 more
wiley   +1 more source

Data from Translational Exposure–Efficacy Modeling to Optimize the Dose and Schedule of Taxanes Combined with the Investigational Aurora A Kinase Inhibitor MLN8237 (Alisertib)

, 2023
Jessica J. Huck, Mengkun Zhang, Jerome T. Mettetal, Arijit Chakravarty, Karthik Venkatakrishnan, Xiaofei Zhou, Rob Kleinfield, Marc L. Hyer, Karuppiah Kannan, Vaishali Shinde, Andy Dorner, Mark Manfredi, Wen Chyi Shyu, Jeffrey Ecsedy   +13 more
openalex   +1 more source

MELEGROS: Monolithic Elephant‐Inspired Gripper with Optical Sensors

Advanced Science, EarlyView.
MELEGROS is a monolithic, elephant‐inspired soft gripper integrating 3D‐printed optical sensors within a pneumatically actuated lattice. Simulation‐guided design decouples tactile and proprioceptive sensing. Characterized through grasping tests, MELEGROS can reach, scoop, and grasp, showcasing a paradigm where fully embedded sensing and continuous ...
Petr Trunin, Diana Cafiso, Anderson Brazil Nardin, Trevor Exley, Lucia Beccai   +4 more
wiley   +1 more source

Space weather with an arc’s ∼2 h trip across the nightside polar cap

Frontiers in Astronomy and Space Sciences
Flow channels can extend across the polar cap from the dayside to the nightside auroral oval, where they lead to localized reconnection and auroral oval disturbances.
Larry R. Lyons, Yukitoshi Nishimura, Jiang Liu, Jiang Liu, Sneha Yadav, Ying Zou, William A. Bristow, Eric Donovan, Nozomu Nishitani   +8 more
doaj   +1 more source

Microscale Mapping of Fiber Strain and Damage in Composite Wrinkled Laminates Using Computed Tomography Assisted Wide‐Angle X‐Ray Scattering

Advanced Science, EarlyView.
This study combines full‐field tomography with diffraction mapping to quantify radial (ε002$\varepsilon _{002}$) and axial (ε100$\varepsilon _{100}$) lattice strain in wrinkled carbon‐fiber specimens for the first time. Radial microstrain gradients (−14.5 µεMPa$\varepsilon \mathrm{MPa}$−1) are found to signal damage‐prone zones ahead of failure, which ...
Hoang Minh Luong, James Trevarthen, Igor Dolbnya, Wadwan Singhapong, Nicholas Pilato, Richard Butler, Jiraphant Srisuriyachot, Alexander J. G. Lunt   +7 more
wiley   +1 more source

Supplemental Table S5 from High-throughput Chemical Screening Identifies Focal Adhesion Kinase and Aurora Kinase B Inhibition as a Synergistic Treatment Combination in Ewing Sarcoma

, 2023
Sarah Wang, Elizabeth E. Hwang, Rajarshi Guha, Allison F. O’Neill, Nicole Melong, Chansey J. Veinotte, Amy Conway Saur, Kellsey Wuerthele, Min Shen, Crystal McKnight, Gabriela Alexe, Madeleine E. Lemieux, Amy Wang, E. D. Hughes, Xin Xu, Matthew B. Boxer, Matthew D. Hall, Andrew L. Kung, Jason N. Berman, Mindy I. Davis, Kimberly Stegmaier, Brian D. Crompton   +21 more
openalex   +1 more source

Supplementary Figure S3 from The Suppression of <i>Aurora-A/STK15/BTAK</i> Expression Enhances Chemosensitivity to Docetaxel in Human Esophageal Squamous Cell Carcinoma [PDF]

, 2023
Eiji Tanaka, Yosuke Hashimoto, Tetsuo Ito, Kan Kondo, Motoshige Higashiyama, Shigeru Tsunoda, Cristián Ortíz, Yoshiharu Sakai, Johji Inazawa, Yutaka Shimada   +9 more
openalex   +1 more source

ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC‐I Antigen Presentation That Promotes Tumor Immune Evasion

Advanced Science, EarlyView.
ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Lei Zhao, Linlin Sheng, Jianhao Qiu, Junjie Ma, Kai Jin, Binggong Zhao, Tianrun Miao, Jing Chen, Yehong Li, Zhan Zhang, Dongfeng Sun, Yongmeng Li, Hui Tian   +12 more
wiley   +1 more source

Effect of the NO concentration on the ratio I₅₅₇.₇/I₄₂₇.₈ in auroras

Solar-Terrestrial Physics
We have examined the effect of the nitrogen oxide concentration on the ratio between λ557.7 nm and λ427.8 nm emission intensities in auroras caused by precipitating electron fluxes, using the numerical simulation method.
Ivanov V. E., Dashkevich Z. V.
doaj   +1 more source

Supplementary Figure 3 from Nupr1-Aurora Kinase A Pathway Provides Protection against Metabolic Stress-Mediated Autophagic-Associated Cell Death [PDF]

, 2023
Tewfik Hamidi, Carla E. Cano, Daniel Grasso, María Noé Garcia, María José Sandí, Ézéquiel Calvo, Jean–Charles Dagorn, Gwen Lomberk, Raúl Urrutia, Sandro Goruppi, Arkaitz Carracedo, Guillermo Velasco, Juan Iovanna   +12 more
openalex   +1 more source