Results 131 to 140 of about 1,059,569 (258)

Metabolic Signatures for Liver Cancer Diagnosis and Mechanistic Insights: A Large‐Scale, Multicenter Study

open access: yesAdvanced Science, EarlyView.
A large‐scale multicenter serum metabolomics study (13 centers, n = 2,149) identified a 9‐metabolite + AFP diagnostic signature for liver cancer (AUC = 0.93). Among the signature, nicotinamide (NAM) was validated as an oncometabolite: NAM enhances NAD+ synthesis, activating SIRT1 to deacetylate and stabilize HIF1α, thereby driving glycolysis, MAPK ...
Yongjie Xu   +13 more
wiley   +1 more source

Knowledge comes, but wisdom lingers: Can wisdom predict authentic leadership?

open access: yes, 2011
Authentic leadership is part of an alternative leadership that is gaining in popularity compared with traditional forms of leadership. It is about making work places more meaningful, bringing perspective and changing the way things operate in ...
Pearce, Liane
core  

Authentic e-learning in higher education [PDF]

open access: yes, 2009
Technologies can be used as powerful cognitive tools when they are used, not for information delivery, but as instruments used by students to solve complex problems.
Herrington, J.
core  

Nanoscale Buried Interface Control in Silicone Hydrogels Enables a Biointerface Engineering Platform

open access: yesAdvanced Science, EarlyView.
A hydrophilic coating with controllable nanoscale thickness is applied to commercial silicone hydrogel contact lenses. By combining comprehensive multi‐modal three‐dimensional characterization with an advanced algorithm, the thickness and chemical information of these multilayered structures are resolved.
Po‐Hsiang Chen   +5 more
wiley   +1 more source

A group coaching approach to authentic leadership development [PDF]

open access: yes
The Portfolio presented here is concerned with the subject of Authentic Leadership Development. This subject has become the focus of much attention in the last 10 years by both researchers and practitioners in the leadership and leadership development ...
Fusco, T.
core  

The relationship between authentic leadership and employee performance [PDF]

open access: yes, 2018
The impact of a leader on his or her followers has been a topic of much research and therefore organizations, including the financial services sector in South Africa, are placing more and more emphasis on what this leadership construct looks like ...
Petzer, Liane
core  

3D Bioprinted Blood–Brain–Tumor Barrier Spheroid‐Based In Situ Evaluation of Anticancer Compounds Against Glioblastoma: ROS‐Producing Ruthenium as a Potential Therapeutic Candidate

open access: yesAdvanced Science, EarlyView.
The blood–brain–tumor barrier (BBTB) penetration by anticancer drugs and their effects on glioblastoma (GBM) is assessed using 3D bioprinted‐spheroids. Anticancer drug‐induced U‐87 MG cell death is quantified through in situ imaging of spheroids using a cancer cell death probe. The Ru compound, a partial P‐gp substrate, induces greater tumor‐cell death
Hyunjung Lee   +5 more
wiley   +1 more source

Learning authentic leadership in New Zealand: A learner-centred methodolgoy and evaluation

open access: yes, 2010
This study provides preliminary examination of the efficacy of the "Best Authentic Leadership Self" exercise. A field quasi-experimental design was conducted with a dual purpose: 1) to ascertain the value of interventions aimed at triggering events to ...
Roche, Maree
core  

Análise comparativa de programas de desenvolvimento de líderes [PDF]

open access: yes, 2015
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia e Gestão do Conhecimento, Florianópolis, 2015.Diferentemente dos estudos da liderança, as pesquisas sobre o desenvolvimento de ...
Esper, Aulina Judith Folle
core  

Lactate‐H3K18la‐RPL11 Axis Drives Gemcitabine Resistance in Pancreatic Cancer by Integrating Protein Synthesis and DNA Damage Repair

open access: yesAdvanced Science, EarlyView.
A lactate‐H3K18la epigenetic axis upregulates RPL11 to drive gemcitabine resistance in pancreatic cancer. RPL11 orchestrates chemoresistance through a dual, compartmentalized role: enhancing cytoplasmic protein synthesis via EEF1A1 stabilization and promoting nuclear DNA damage repair by co‐activating PARP14, thus ensuring robust cell survival ...
Lijun Zhao   +10 more
wiley   +1 more source

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