Results 31 to 40 of about 55,577 (266)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Re-authorization of gelatin and collagen of ruminant origin in non-ruminant feed: a new analytical challenge for the control of the feed ban

open access: yesBiotechnologie, Agronomie, Société et Environnement, 2022
Description of the subject. A recent revision of the feed ban provisions authorizes the use of ruminant collagen and gelatin in feed for non-ruminant farmed animals.
Olivier Fumière   +2 more
doaj  

A detailed workflow to develop QIIME2-formatted reference databases for taxonomic analysis of DNA metabarcoding data

open access: yesBMC Genomic Data, 2022
Background The DNA metabarcoding approach has become one of the most used techniques to study the taxa composition of various sample types. To deal with the high amount of data generated by the high-throughput sequencing process, a bioinformatics ...
Benjamin Dubois   +7 more
doaj   +1 more source

Offline User Authentication Ensuring Non-Repudiation and Anonymity

open access: yesSensors, 2022
User authentication is the key to ensuring that only authorized users can deal with specific affairs and access services. Applications or systems possessing different properties or requirements need different authentication schemes.
Ya-Fen Chang, Wei-Liang Tai, Ka-Ho Fung
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

Preparation of microencapsulated NH4H2PO4 solution and flame suppression of lithium battery thermal runaway

open access: yesCase Studies in Thermal Engineering
This study addresses the bottleneck issue of insufficient functionality of traditional extinguishing agents in the fire prevention and control of lithium batteries in new energy vehicles.
Yang Liping   +8 more
doaj   +1 more source

Authenticity, authentication and experiential authenticity: telling stories in museums [PDF]

open access: yesSocial & Cultural Geography, 2018
This article examines how different types of authenticity and authentication work together to inspire museum stories, and personal identification with them, in ways that encourage experiential authenticity. It begins by outlining conceptions of object and existential authenticity and demonstrating how they are bound up with processes of hot and cool ...
openaire   +1 more source

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