Results 271 to 280 of about 645,588 (340)

Graphitized Biochar Derived from Agricultural Wastes Enhances Methanogenesis via Conductivity‐Driven Direct Interspecies Electron Transfer

open access: yesAdvanced Science, EarlyView.
This work clarifies how feedstocks and their structural features promote methanogenesis, and identifies the key regulatory factors, reducing pollution to the global environment, and also helps to alleviate the energy crisis. This is the first study to systematically link feedstock lignin content, pyrolysis conditions, biochar graphitization, and DIET ...
Caiyun Yang   +18 more
wiley   +1 more source

Neural Response Reliability as a Marker of the Transition of Neural Codes along Auditory Pathways

open access: yesAdvanced Science, EarlyView.
Decoding sound from neural activity in mice reveals a striking shift in how the brain encodes sound: from precise but redundant timing codes in early auditory areas to efficient, synergistic rate‐based codes in the cortex. This transformation highlights a robust neural strategy for turning complex acoustic input into coherent perception across the ...
Alexa Buck   +7 more
wiley   +1 more source

High Oxidation State V‐O‐Co Structure Promotes the Role of V‐*O Intermediates in Efficient HMF Oxidation

open access: yesAdvanced Science, EarlyView.
By designing a high oxidation state VH‐O‐CoH structure, the V‐*O intermediate can be effectively generated, thereby facilitating the catalytic oxidation of HMF. This innovative design strategy demonstrates broad applicability, as it not only enables the formation of the active intermediate in various materials (V‐Ni2P), but also facilitates its ...
Honglei Wang   +6 more
wiley   +1 more source

DCAF12 Ubiquitin Ligase Promotes Lung Cancer Metastasis by Modulating the TRiC/CCT Chaperonin Complex

open access: yesAdvanced Science, EarlyView.
This study elucidates how DCAF12 facilitates non‐degradative ubiquitination to stabilize TRiC/CCT, thereby enhancing the folding capacity of chaperonins. This mechanism promotes the maturation of cytoskeletal proteins and activates key oncogenic drivers, including YAP, STAT3, and mTOR, ultimately driving metastatic progression in lung cancer.
Zhenyi Wang   +13 more
wiley   +1 more source

Globotriaosylceramide Gb3 Influences Wound Healing and Scar Formation by Orchestrating Fibroblast Heterogeneity

open access: yesAdvanced Science, EarlyView.
In superficial second‐degree burn wounds, Gb3 turns on genes related to papillary cells through the FGF2 signaling pathway. This increases the ability of cells to break down fibrin and decreases fibrosis, which ultimately prevents scar formation in burn injuries.
Sujie Xie   +13 more
wiley   +1 more source

Hypoxia‐Induced PRMT1 Lactylation Drives Vimentin Arginine Asymmetric Dimethylation in Tumor Metastasis

open access: yesAdvanced Science, EarlyView.
Hypoxia triggers lactylation of PRMT1 at K134/K145, enhancing its methyltransferase activity to asymmetrically dimethylate vimentin R64. This post‐translational cascade promotes vimentin filament assembly, cytoskeletal remodeling, and tumor metastasis, with PRMT1 inhibition (MS023) reducing metastatic colonization.
Jia Zhou   +16 more
wiley   +1 more source

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