Results 41 to 50 of about 165,576 (247)
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Authenticity, empathy, and the creative imagination [PDF]
, 2021 This article reviews the changing beliefs about artistic integrity and aesthetic value that feed into judgements of rock authenticity, taking issue with scholarship that reduces authenticity to acts of misguided judgement, myths, conceits, and fakery. It
Negus, Keith +5 more
core +1 more source
Redai dili, 2023 Pertinent evidence clearly shows that food not only meets the basic needs of tourists, but is also an important carrier of the tourist experience. We investigated the type of restaurants that tourists favor.
Zhao Zhifeng, Li Zhiwei
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Authenticity as authentication
Popular Music, 2002 This article argues for the prematurity of any dismissal of the notion of authenticity as meaningful within popular music discourse. It synthesises a range of views as to how authenticity is constructed, and offers a tri-partite typology dependent on asking who, rather than what, is being authenticated.
openaire +3 more sources
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source
Dreaming of drams: Authenticity in Scottish whisky tourism as an expression of unresolved Habermasian rationalities [PDF]
, 2011 In this paper, the production of whisky tourism at both independently owned and corporately owned distilleries in Scotland is explored by focusing on four examples (Arran, Glengoyne, Glenturret and Bruichladdich).
Spracklen, K, Karl Spracklen
core +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
Children’s reasoning about violations of authenticity [PDF]
, 2013 textWhen do children begin to realize that the authenticity of an object is not inherent to an object itself, but instead depends on the information one has about the object in question?
Schepp, Brooke Jessica
core