Results 71 to 80 of about 224,651 (296)

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

FEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai, Yong Xu, Jingjing Ma, Ratchanee Duangrat, Chen Yan, Jingyan Liang, Hua Wei, Bin Jiang, Tao‐Sheng Li   +8 more
wiley   +1 more source

Animation in immersive environments: expanding theories of authenticity in educational, historical, and political contexts

Con A de Animación
This paper examines and discusses potential factors that may trigger authenticity in animated immersive environments. Our discussion draws upon three forms of authenticity, categorized as objective, constructive or symbolic, and existential authenticity.
Hannes Rall, Wibke Weber, Emma Harper
doaj   +1 more source

Time to unravel the conceptual confusion of authenticity and fidelity and their contribution to learning within simulation-based nurse education. A discussion paper [PDF]

, 2014
High-fidelity patient simulation is a method of education increasingly utilised by educators of nursing to provide authentic learning experiences. Fidelity and authenticity, however, are not conceptually equivalent.
Bland, Andrew, Topping, Annie, Bland, Andrew J., Tobbell, Jane, Bland, Andrew J, Topping, Annie; id_orcid   +5 more
core   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Food Souvenir Authenticity and the Process of Emergence: The Case of Nougat Cracker Syndrome in Taipei, Taiwan

Tourism and Hospitality
This study explores the phenomenon of nougat cracker syndrome among Korean tourists in Taipei, Taiwan, foregrounding the evolving concept of authenticity in tourism food souvenirs.
Lankyung Kim, Chul Jeong
doaj   +1 more source

Children’s reasoning about violations of authenticity [PDF]

, 2013
textWhen do children begin to realize that the authenticity of an object is not inherent to an object itself, but instead depends on the information one has about the object in question?
Schepp, Brooke Jessica
core  

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Not all experiences of (in)authenticity are created equal: A latent class analysis approach(retitled Identifying Differences in the Experience of (In)Authenticity: A Latent Class Analysis Approach)

Frontiers in Psychology, 2014
Generally, psychologists consider state authenticity– that is, the subjective sense of being one’s true self – to be a unitary and unidimensional construct, such that (a) the phenomenological experience of authenticity is thought to be similar no matter ...
Alison P. Lenton, Letitia eSlabu, Martin eBruder, Constantine eSedikides   +3 more
doaj   +1 more source