Results 101 to 110 of about 133,319 (289)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Renegotiating Authoritative Conventions: Wilkie Collins's Blurring of High and Low in The Law and the Lady, The Moonstone and Armadale

, 2013
This thesis is interested in Wilkie Collins’s blurring of high and low, authoritative and non-authoritative discourses, in The Law and the Lady, The Moonstone and Armadale.
Gullander-Drolet, Louise
core  

Finding Authoritative Researchers on Academic Web Sites

, 2008
In this paper, we present a methodology for finding authoritative researchers by analyzing academic Web sites. We show a case study in which we concentrate on a set of Czech computer science departments- Web sites.
Dalibor Fiala, Karel Jezek, Francois Rousselot   +2 more
core   +1 more source

Authoritative Parenting Style and Grit in Medical Students: The Mediating Role of Hope

International Journal of Positivity & Well-Being
Medical education demands perseverance and resilience, making grit, a psychological trait that involves perseverance and passion for long-term goals, a crucial factor for academic and professional success.
Fatin Rohmah Nur Wahidah, Nadia Aulia Rahma, Pambudi Rahardjo, Hilda Meriyandah Agil, Ayu Kurnia S, Astika Nurul Hidayah   +5 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

FEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

A Single Authoritative List of the World's Species: background and roadmap

Even though (some) species lists are in a state of disorder, they are extensively used by scientists, policymakers and international organizations. This chapter considers two ways of alleviating the problems that taxonomic disorder causes for these users
Garnett, Stephen, Zachos, Frank, Christidis, Les, Conix, Stijn   +3 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Authoritative parenting among immigrant Chinese mothers of preschoolers

, 2013
The goals of this study were: (a) to examine authoritative parenting style among Chinese immigrant mothers of young children, (b) to test the mediational mechanism between authoritative parenting style and children’s outcomes; and (c) to evaluate 3 ...
Schultz, David, Cheah, Charissa S. L., Leung, Christy Y. Y., Tahseen, Madiha   +3 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source