Results 61 to 70 of about 900,225 (296)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
PSEUDONYMITY SYSTEM ADMINISTRATOR GUIDE [PDF]
, 2013 EMI Pseudonymity System provides users with a way to hide their true identity behind a pseudonymous ...
White, John
core +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source
ЭЛЕКТРОННЫЙ МЕТОДИЧЕСКИЙ АППАРАТ ПРЕДМЕТИЗАТОРА В ГПНТБ СО РАН
Библиосфера, 2010 The formation of rules and methodical instrument for a subject cataloger began in SPSTL SB RAS in 2007. The authors describe the structure, functions and technology of operating the electronic file of methodical decisions on subject cataloging.
doaj
Vrednotenje normativne baze podatkov CONOR.SI s stališča visokošolskih katalogizatorjev / Evaluation of the CONOR.SI authority file from cataloguers' point of view in academic libraries [PDF]
Organizacija ZnanjaAuthority control is an important part of cataloguing. The Slovene CONOR.SI authority file including authority records for individual and corporate authors, enables among others identification of authors.
Urška Zupančič, Marija Petek
doaj +1 more source
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Geokoordinaten in Bibliotheksdaten. Grundlage für innovative Nachnutzung
o-bib. Das offene Bibliotheksjournal, 2015 Geokoordinaten übernehmen die Rolle von Identifikatoren, die von den unterschiedlichsten Systemen verstanden und in Anwendungen benutzt werden. Wenn die geografischen Normdaten der Gemeinsamen Normdatei (GND) Geokoordinaten haben und bei Kartenblättern ...
Esther Scheven
doaj +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source