Results 151 to 160 of about 1,264,501 (316)

Potent and Selective IGF‐IIR‐Recruiting Bifunctional Molecules for Targeted Lysosomal Degradation of Extracellular and Membrane Proteins

open access: yesAdvanced Science, EarlyView.
Lysosome‐targeting chimeras (LYTACs) enable degradation of extracellular and membrane proteins via lysosomal trafficking. We report a novel IGF‐II mutant (Del1–7, Y27L) that selectively engages IGF‐IIR while avoiding IGF‐IR and IR‐A. mutIGF‐II–based LYTACs enhance target internalization and degradation and support a genetically encodable, all‐protein ...
Yuan Zhao   +16 more
wiley   +1 more source

Petroleum Production Engineering, author M. Čikeš

open access: yesRudarsko-geološko-naftni zbornik, 2016
Knjiga „Proizvodno inženjerstvo nafte i plina“ (slika 1) autora prof. dr. sc. Marina Čikeša, redovitog profesora u miru Rudarsko-geološko-naftnog fakulteta Sveučilišta u Zagrebu, tiskana je 2015. godine kao sveučilišni udžbenik (Manualia universitatis studiorum Zagrabiensis).
openaire   +1 more source

Farmer management of production risk on degraded lands: the role of wheat genetic diversity in Tigray Region, Ethiopia [PDF]

open access: yes
"This paper investigates the effects of wheat genetic diversity and land degradation on risk and agricultural productivity in less favored production environments of a developing agricultural economy.
Chavas, Jean-Paul   +2 more
core  

Diversity of Pharmaceuticals Enhances Antibiotic Resistance in the Invertebrate Gut via Biofilm‐Mediated Mechanisms

open access: yesAdvanced Science, EarlyView.
Pharmaceutical diversity acts as an independent driver of antibiotic resistance in soil invertebrates. While bulk soil remains unaffected, the collembolan gut microbiome exhibits significant resistance gene enrichment under complex chemical exposure and diurnal warming.
Yi‐Fei Wang   +11 more
wiley   +1 more source

In search of the NAIRU [PDF]

open access: yes
The relationship between the unemployment rate and the nonaccelerating inflation rate of unemployment (NAIRU) is presumed to be an inflationary bellwether, but recent inflation predictions based on it have not been successful.
David Altig, Paul Gomme
core  

Bioenergy Cropping Reduces the Spatiotemporal Scaling of Soil Bacterial Biodiversity

open access: yesAdvanced Science, EarlyView.
Consistent with patterns observed in plant and animal communities, soil bacterial communities exhibit significant species–time–area and phylogenetic–time–area relationships independent of nested structure. Bioenergy cropping significantly reduces the spatiotemporal scaling rates, particularly in sandy loam soils.
Zhencheng Ye   +19 more
wiley   +1 more source

Productivity in Canada: Does Firm Size Matter? [PDF]

open access: yes
The research findings highlighted in this article suggest that firm-size differences play a significant role in explaining the productivity gap between Canada and the United States.
Césaire Meh, Danny Leung, Yaz Terajima
core  

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