Results 31 to 40 of about 1,264,501 (316)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Global evidence of positive biodiversity effects on spatial ecosystem stability in natural grasslands

Nature Communications, 2019
Biodiversity–productivity relationships in natural ecosystems are highly variable, although positive relationships are most common. Here, using HerbDivNet data, the authors show that biodiversity stabilizes rather than increases plant productivity in ...
Yongfan Wang, Marc W. Cadotte, Yuxin Chen, Lauchlan H. Fraser, Yuhua Zhang, Fengmin Huang, Shan Luo, Nayun Shi, Michel Loreau   +8 more
doaj   +1 more source

Warming from tropical deforestation reduces worker productivity in rural communities

Nature Communications, 2021
It is expected that tropical deforestation and related increases in heat exposure have negative impacts on labour productivity, but the size of the effect is not well known. Here, the authors show that deforestation reduces productivity by 8.22% in rural
Yuta J. Masuda, Teevrat Garg, Ike Anggraeni, Kristie Ebi, Jennifer Krenz, Edward T. Game, Nicholas H. Wolff, June T. Spector   +7 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Internal Sources of Labour Productivity Growth in Russia

Мир новой экономики, 2020
In this article, the authors analysed the readiness of Russian regions for the integration of technological innovations. In this context, managerial dichotomy “borrowing/creation of innovations” is of fundamental importance.
E. V. Balatsky, N. A. Ekimova
doaj   +1 more source

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Measuring information dependency for construction engineering projects

Journal of Civil Engineering and Management, 2013
Information dependency may be the most important key for managing information exchange to reduce project risks. Studies to date have not successfully discovered objective and quantitative surrogate to measure information dependency.
Pin-Chao Liao, Stephen R. Thomas, William J. O’Brien   +2 more
doaj   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Current state of labour productivity in the economy of developed countries [PDF]

E3S Web of Conferences, 2019
The article is devoted to the problems of labour productivity increase. It studies trends in labour productivity growth in 12 developed countries and presents a comparative analysis of individual factors that directly affect labour productivity ...
Bogatyreva Irina, Simonova Marina, Privorotskaya Elena   +2 more
doaj   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source