Results 31 to 40 of about 3,384,967 (292)
, 2022 Introduction GVCs and Productivity: A Conceptual Review GVC Participation for APO Member Countries Impact of GVC Participation on Productivity Conclusion References ...
Kim, Daehong +2 more
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Productivity in manufacturing: measurement and interpretation [PDF]
, 2013 This paper examines recent productivity performance in Manufacturing, with particular focus on the causes of its decline. In particular, this paper: analyses Multifactor productivity (MFP) change and its proximate causes (value added, labour and ...
Paula Barnes
core
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
iForest - Biogeosciences and Forestry, 2012 For long time a quantitative assessment of the productivity of Italian researchers has been lacking; the first and unique assessment was the Three-Year Research Evaluation for the period 2001-2003.
Chirici G
doaj +1 more source
Around one third of current Arctic Ocean primary production sustained by rivers and coastal erosion
Nature Communications, 2021 The Arctic Ocean is influenced by carbon and nutrients from rivers and erosion, but how this affects phytoplankton productivity is not understood. Here, the authors use a spatio-temporally resolved biogeochemical model to estimate that the input of ...
Jens Terhaar +4 more
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
PRODUÇÃO CIENTÍFICA BRASILEIRA EM FINANÇAS NO PERÍODO 2000-2010 [PDF]
RAE: Revista de Administração de Empresas, 2013 This article conducts a quantitative and qualitative appraisal of the bibliography of financial articles published in 11 Brazilian scientific journals, through surveys into the question of co-authorships and other priority areas, together with an ...
Ricardo Pereira Câmara Leal +2 more
doaj
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source