Results 41 to 50 of about 307,296 (247)
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Measuring information dependency for construction engineering projects
Journal of Civil Engineering and Management, 2013 Information dependency may be the most important key for managing information exchange to reduce project risks. Studies to date have not successfully discovered objective and quantitative surrogate to measure information dependency.
Pin-Chao Liao +2 more
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The Power of Lotka’s Law Through the Eyes of R [PDF]
Revista Română de Statistică, 2015 The paper aims to outline the author impact based on Lotka’s Law using R. Lotka’s Law is well known as “the inverse square law of scientific productivity.” It states that the number of authors publishing a certain number of articles is a fixed ratio to ...
Alon Friedman
doaj
The productivity-biodiversity relationship varies across diversity dimensions
Nature Communications, 2019 The relationships between ecosystem productivity and plant diversity are complex. Here, the authors show that sites with high productivity typically have reduced species diversity but high functional and phylogenetic diversity, potentially owing to the ...
Philipp Brun +6 more
doaj +1 more source
Productivity in services: a systematic review
Revista Produção Online, 2013 Through the method of Systematic Review of Literature (SRL), this study conducted an analysis of productivity in services. For this purpose, fourteen journals of Operations Management and Scielo database were consulted.
Noel Torres Júnior +1 more
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
, 2015 This chapter explores the historical relationship between the branded media entertainment of Tarzan and the rise of consumer culture in the 1920s and 1930s. It argues that the transmedia licensing of this property across pulp magazines, comics, and radio reflected the growing embrace of brand-franchise logics throughout the business landscape of ...
openaire +2 more sources
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source