Results 71 to 80 of about 585,856 (303)
Genetic Diagnosis and Discovery Enabled by Large Language Models
Advanced Science, EarlyView.We demonstrate that large language models (LLMs) can facilitate genetic diagnosis and discovery. LLMs were used to solve four types of genetic problems of sequentially increased complexity. An LLM‐based pipeline could analyze genetic variants in the genomic sequences of human hearing loss or rare genetic disease patients and assist in identifying ...
Tao Tu +25 more
wiley +1 more source
Linguistic markers of autism in girls: evidence of a “blended phenotype” during storytelling
Molecular Autism, 2019 Background Narrative abilities are linked to social impairment in autism spectrum disorder (ASD), such that reductions in words about cognitive processes (e.g., think, know) are thought to reflect underlying deficits in social cognition, including Theory
Jaclin Boorse +6 more
doaj +1 more source
Exploring face perception in disorders of development: evidence from Williams syndrome and autism [PDF]
, 2008 Individuals with Williams syndrome (WS) and autism are characterized by different social phenotypes but have been said to show similar atypicalities of face-processing style.
Baron-Cohen +49 more
core +1 more source
Cortical Somatostatin Neurons Regulate Seizure Susceptibility via MINAR1/Gαs–cAMP Signaling
Advanced Science, EarlyView.Our study identifies MINAR1 as a novel regulator of cortical interneuron excitability and seizure susceptibility. MINAR1 is preferentially expressed in SST+ interneurons. Genetic ablation of MINAR1 leads to seizure hypersensitivity, reduced SST+ neuron excitability, and impaired Gαs–cAMP signaling, disrupting the E/I balance.
Wei‐Tang Liu +20 more
wiley +1 more source
Advanced Science, EarlyView.Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han +10 more
wiley +1 more source
Effects of oxytocin administration on salivary sex hormone levels in autistic and neurotypical women
Molecular Autism, 2020 Background Oxytocin administration, which may be of therapeutic value for individuals with social difficulties, is likely to affect endogenous levels of other socially relevant hormones.
Tanya L. Procyshyn +9 more
doaj +1 more source
Large scale validation of an early-age eye-tracking biomarker of an autism spectrum disorder subtype
Scientific Reports, 2022 Few clinically validated biomarkers of ASD exist which can rapidly, accurately, and objectively identify autism during the first years of life and be used to support optimized treatment outcomes and advances in precision medicine.
Teresa H. Wen +10 more
doaj +1 more source
, 2009 Many studies have been conducted to observe the effect of contact on attitudes toward people with mental illnesses, but few studies have observed the effect of contact on attitudes toward individuals on the autism spectrum specifically.
Edyvean, Carrie
core +2 more sources
Favourable approach that influence autism students learning language process [PDF]
, 2021 Education is important for all, including those students with special needs.In this context, learning process for students with special needsis certainly different from normal students, with special developed curriculum, as well as special skills for ...
Che Lah, Noor Hidayah +4 more
core
Advanced Science, EarlyView.We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun +13 more
wiley +1 more source