Results 181 to 190 of about 361,059 (344)

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Unveiling autism spectrum disorder for the pediatrician. [PDF]

J Pediatr (Rio J)
Vasconcelos MM, Vasconcelos LGA, Brito AR.   +2 more
europepmc   +1 more source

Behavioral and epileptic phenotypes in a CHD2‐related developmental delay model

Epilepsia, EarlyView.
Abstract Objective Heterozygous loss‐of‐function mutations in the CHD2 gene, encoding chromodomain helicase DNA‐binding protein 2, are associated with severe childhood onset epilepsy, global developmental delay, and autistic features. Animal models that accurately recapitulate human phenotypes are crucial for understanding rare neurodevelopmental ...
Anat Mavashov, Shaked Turk, Yael Sarusi, Marina Brusel, Rotem Ben Tov Perry, Shir Quinn, Yael Almog, Karni Vilian, Mor Yam, Igor Ulitsky, Moran Rubinstein   +10 more
wiley   +1 more source

Unraveling pathogenesis and potential biomarkers for autism spectrum disorder associated with HIF1A pathway based on machine learning and experiment validation

J. Jean Cui, Heli Li, Cong Hu, Feiyan Zhang, Yunjie Li, Ying Weng, Liping Yang, Y.Q. Li, M.L. Yao, Hao Li, Xiaoping Luo, Yan Hao   +11 more
openalex   +1 more source

The Broader Autism Phenotype in Parents of Children with Autism Spectrum Disorder: Implications for the Diagnostic Process and Relationship to Child Autism Spectrum Disorder Phenotype

, 2019
Eric Rubenstein
openalex   +2 more sources

Autism Behavior Inventory: A Novel Tool for Assessing Core and Associated Symptoms of Autism Spectrum Disorder [PDF]

, 2017
Abi Bangerter, Seth Ness, Michael G. Aman, Anna J. Esbensen, Matthew S. Goodwin, Géraldine Dawson, Robert L. Hendren, Bennett Leventhal, Anzalee Khan, Mark Opler, Adrianne Harris, Gahan Pandina   +11 more
openalex   +1 more source

From Brain Health to Brain Economy

Brain Health, EarlyView.
Yongjun Wang
wiley   +1 more source

Memantine treatment in individuals with GRIN gain‐of‐function variants is associated with improvements in behavior, development, and seizure frequency

Epilepsia, EarlyView.
Abstract Objective GRIN‐related disorders due to pathogenic variants in GRIN1, GRIN2A, GRIN2B, or GRIN2D genes are associated with altered N‐methyl‐D‐aspartate receptor (NMDAR) function. Functional changes include gain (GoF) and loss of receptor function (LoF). Clinical reports describing the use of the NMDAR blocker memantine in GRIN‐related disorders
Maike Karnstedt, Riley E. Perszyk, Scott J. Myers, Ellington McDaniels, Marta Somorai, Ingo Borggraefe, Danielle C. M. Veenma, An‐Sofie Schoonjans, Pasquale Striano, Tadeu A. Fantaneanu, Steffen Syrbe, Kristen Park, Wenjuan Chen, Hongjie Yuan, Stephen F. Traynelis, Timothy A. Benke, Johannes R. Lemke, Ilona Krey   +17 more
wiley   +1 more source

A Review of Therapeutic Approaches for Autism Spectrum Disorder. [PDF]

Brain Sci
Hai Y, Bai S, Qiao H, Li D, Wang D, Xia M.   +5 more
europepmc   +1 more source

The specific cognitive abilities in neuro- and social cognition and their compensatory relationship that predict social adaptation in adults with autism spectrum disorder

, 2018
Sadao Otsuka, Shota Uono, Sayaka Yoshimura, Shuo Zhao, Motomi Toichi   +4 more
openalex   +2 more sources