Results 71 to 80 of about 144,447 (302)

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Trends in Obesity among Iranian Children and Adolescents: 2000–2016

Journal of Tehran University Heart Center, 2020
None
Ensiyeh Jenabi, Salman Khazaei
doaj   +1 more source

A Brain‐Wide Atlas of Astrocytic Oxytocin Receptors Reveals a Glial Basis for Nucleus Accumbens Modulation of Affiliative Behavior

Advanced Science, EarlyView.
The cellular actors of oxytocin signaling are under intense scrutiny. A brain‐wide anatomical and functional analysis in mice and rats reveals widespread expression of oxytocin receptors in astrocytes. These receptors are functionally active and, in the nucleus accumbens, selectively regulate male social affiliation.
Clémence Denis, Stefan Stojilkovic, Kai‐Yi Wang, Cristina Márquez, Annabel C. Kleinwächter, Angel Baudon, Yuval Podpecan, Aurélia Ces, Mélanie Kremer, Isabelle Arnoux, Nathalie Rouach, Jemima Helen, Sophie Trender, Andreas Wallkum, Selina Wunsch, Franziska Schommer, Moritz C. Wimmer, Tim Schubert, Felix Franke, Jabir Aliyu Muhammad, Eva M. Eisemann, Ingrid Camila Possa‐Paranhos, Cassandra Baumann, Pierre‐Alexis Derrien, Quirin Krabichler, Cosmo Garcia, Henning Fröhlich, Matthew K. Kirchner, Valery Grinevich, Pascal Darbon, Javier E. Stern, Ferdinand Althammer, Alexandre Charlet   +32 more
wiley   +1 more source

Nonspecificity and theory of mind: new evidence from a nonverbal false-sign task and children with autism spectrum disorders [PDF]

, 2014
Understanding of false belief has long been considered to be a crucial aspect of theory of mind that can be explained by a domain-specific mechanism. We argue against this claim using new evidence from a non-verbal false representation task (false-sign ...
Iao, L-S, Leekam, SR, Iao, Lai-Sang, Leekam, Susan R.   +3 more
core   +1 more source

Child Mortality Rate in Iran Compared with Other Eastern Mediterranean Countries Based on WHO Report in 2017

Iranian Journal of Public Health, 2020
NO ...
Ensiyeh JENABI, Salman KHAZAEI
doaj   +1 more source

A Study of How Moral Courage and Moral Sensitivity Correlate with Safe Care in Special Care Nursing

The Scientific World Journal, 2022
Background. Nursing is a caring profession, and nurses who have moral sensitivity and moral courage presumably can provide safe and better care for patients.
Fateme Mohammadi, Banafsheh Tehranineshat, Afsaneh Ghasemi, Mostafa Bijani   +3 more
doaj   +1 more source

Prior Expectations Bias Confidence Judgments Through Parietal Alpha‐Band Modulation

Advanced Science, EarlyView.
ABSTRACT Humans possess the metacognitive ability to estimate the likely accuracy of their own decisions through confidence judgments. Yet, whether prior information shapes confidence and the neural mechanisms mediating such influence, remain to be determined.
Luca Tarasi, Anna Pasini, Domenico Romanazzi, Margherita Covelli, Vincenzo Romei   +4 more
wiley   +1 more source

Reinforcement and Maintenance of Human Resources for Health Systems during Long-Term Crises: A Systematic Review of Systematic Reviews

Emergency Medicine International, 2021
Background. Human resources are one of the most critical organizational resources, the reinforcement and maintenance of whom require much energy in health organizations, particularly in long-term crises.
Amir Mohammad Salehi, Salman Khazaei, Motahareh Masumi, Farnaz Shavandi, Mostafa Kavand, Ensiyeh Jenabi, Mahnaz Khatiban   +6 more
doaj   +1 more source

Analysis of common genetic variation across targets of microRNAs dysregulated both in ASD and epilepsy reveals negative correlation

Frontiers in Genetics, 2023
Genetic overlap involving rare disrupting mutations may contribute to high comorbidity rates between autism spectrum disorders and epilepsy. Despite their polygenic nature, genome-wide association studies have not reported a significant contribution of ...
Carol Stella, Carol Stella, Carol Stella, Covadonga M. Díaz-Caneja, Covadonga M. Díaz-Caneja, Covadonga M. Díaz-Caneja, Covadonga M. Díaz-Caneja, Maria Jose Penzol, Maria Jose Penzol, Maria Jose Penzol, Alicia García-Alcón, Alicia García-Alcón, Alicia García-Alcón, Andrea Solís, Andrea Solís, Andrea Solís, Álvaro Andreu-Bernabeu, Álvaro Andreu-Bernabeu, Álvaro Andreu-Bernabeu, Xaquín Gurriarán, Xaquín Gurriarán, Xaquín Gurriarán, Celso Arango, Celso Arango, Celso Arango, Celso Arango, Mara Parellada, Mara Parellada, Mara Parellada, Mara Parellada, Javier González-Peñas, Javier González-Peñas, Javier González-Peñas   +32 more
doaj   +1 more source

Gasdermin D‐Mediated Release of IL‐33 Results in Fetal Brain Developmental Abnormalities During Maternal Colitis

Advanced Science, EarlyView.
Under colitis, Gsdmd mediates the release of IL‐33 from the epithelium of pregnant mice. IL‐33 can cross the placenta and enhance the proliferative capacity of neural stem cells, ultimately resulting in behavioral deficits in the offspring. Excessive pyroptosis in the colonic epithelium also triggers the translocation of LPS, which in turn increases ...
Huiyang Jia, Shukui Zhang, Kai Ma, Jie Zhou, Jianwei Jiao   +4 more
wiley   +1 more source