Results 61 to 70 of about 2,523,609 (254)

A Study of How Moral Courage and Moral Sensitivity Correlate with Safe Care in Special Care Nursing

The Scientific World Journal, 2022
Background. Nursing is a caring profession, and nurses who have moral sensitivity and moral courage presumably can provide safe and better care for patients.
Fateme Mohammadi, Banafsheh Tehranineshat, Afsaneh Ghasemi, Mostafa Bijani   +3 more
doaj   +1 more source

Analysis of common genetic variation across targets of microRNAs dysregulated both in ASD and epilepsy reveals negative correlation

Frontiers in Genetics, 2023
Genetic overlap involving rare disrupting mutations may contribute to high comorbidity rates between autism spectrum disorders and epilepsy. Despite their polygenic nature, genome-wide association studies have not reported a significant contribution of ...
Carol Stella, Carol Stella, Carol Stella, Covadonga M. Díaz-Caneja, Covadonga M. Díaz-Caneja, Covadonga M. Díaz-Caneja, Covadonga M. Díaz-Caneja, Maria Jose Penzol, Maria Jose Penzol, Maria Jose Penzol, Alicia García-Alcón, Alicia García-Alcón, Alicia García-Alcón, Andrea Solís, Andrea Solís, Andrea Solís, Álvaro Andreu-Bernabeu, Álvaro Andreu-Bernabeu, Álvaro Andreu-Bernabeu, Xaquín Gurriarán, Xaquín Gurriarán, Xaquín Gurriarán, Celso Arango, Celso Arango, Celso Arango, Celso Arango, Mara Parellada, Mara Parellada, Mara Parellada, Mara Parellada, Javier González-Peñas, Javier González-Peñas, Javier González-Peñas   +32 more
doaj   +1 more source

SemanticST: A Scalable Multi‐Contextual Graph Learning Framework for Uncovering Spatial Niches and Robust Multi‐Sample Integration in Spatial Transcriptomics

Advanced Science, EarlyView.
Technical limitations often let dominant signals overshadow rare cell types and fine‐grained heterogeneity in spatial transcriptomics. SemanticST, a graph neural network using multi‐semantic graph fusion and a novel min‐cut loss, recovers these subtle patterns.
Roxana Zahedi, Ahmadreza Argha, Nona Farbehi, Ivan Bakhshayeshi, Thantrira Porntaveetus, Youqiong Ye, Nigel H. Lovell, Hamid Alinejad‐Rokny   +7 more
wiley   +1 more source

Neon Chalk: Designing Software to Support Drawing as Play for Children with Autism Spectrum Disorders [PDF]

, 2009
Neon Chalk is a prototype piece of software designed to support drawing as play, for children with Autism Spectrum Disorders (ASD). It incorporates a minimalist interface to reduce distraction while drawing, compelling colours and sound that are ...
Shannon, Grant
core  

Investigation into factors associated with the provision of effective education for children with autistic spectrum disorders [PDF]

, 2003
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This thesis investigates the factors associated with provision of education for children with autism spectrum disorders.
Tissot, Catherine
core   +6 more sources

Reinforcement and Maintenance of Human Resources for Health Systems during Long-Term Crises: A Systematic Review of Systematic Reviews

Emergency Medicine International, 2021
Background. Human resources are one of the most critical organizational resources, the reinforcement and maintenance of whom require much energy in health organizations, particularly in long-term crises.
Amir Mohammad Salehi, Salman Khazaei, Motahareh Masumi, Farnaz Shavandi, Mostafa Kavand, Ensiyeh Jenabi, Mahnaz Khatiban   +6 more
doaj   +1 more source

Grtp1 Safeguards Against Paternal Reproductive Aging and Intergenerational Behavioral Deficits by Preserving Redox Homeostasis

Advanced Science, EarlyView.
This study identifies that Grtp1 maintains germline redox homeostasis by interacting with PRDX1/4‐TXN to antagonize paternal reproductive aging. Growth hormone restores Grtp1 expression, rectifies aberrant sperm DNA methylation, and ameliorates intergenerational anxiety and social deficits, highlighting the GH‐GRTP1 axis as a promising intervention ...
Yingdong Liu, Shanyao Liu, Haixin Liang, Jiani Yang, Yanhe Li, Jiqing Yin, Xueguang Zhang, Yan Zhang, Dandan Bai, Zihui Yan, Zhuoao Zhang, Yanping Jia, Kuisheng Liu, Yifan Sheng, Jiani Xiang, Chenxiang Xi, Baoxing Dong, Xinyi Lei, Jiayu Chen, Hong Wang, Yi Guo, Yanping Zhang, Shaorong Gao, Wenqiang Liu   +23 more
wiley   +1 more source

Improving Use of Social Communicative Gestures by Children with Autism

Behavioral Sciences
Difficulties in social communication are a core characteristic of autism. Gesture use in children with autism is often delayed or atypical, with reduced frequency, diversity, and spontaneity.
Rebecca J. Barall, M. Alice Shillingsburg   +1 more
doaj   +1 more source

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Drug Repurposing for Treating NCOR‐Related Intellectual Disability

Advanced Science, EarlyView.
An autism‐associated NCOR1 heterozygous mutation upregulates NRGs and activates NRG backward signaling in hypothalamic GABAergic neurons in mouse models, leading to Gabra2 downregulation and cognitive deficits, which can be therapeutically targeted by repurposing FDA‐approved drugs.
Yan Kong, Wenjun Zhou, Yuxiang Sun, Zihan Huang, Zhiyue Liu, Udhaya Kumar. S, Chenyan Li, Yi Lu, Chengchuang Song, Veronica C. Ciliberto, Makenna Mack, Lana E. Kim, Zhaoyong Hu, Fang Luo, Aihua Cao, Zheng Sun   +15 more
wiley   +1 more source