Results 71 to 80 of about 1,118,223 (234)

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

open access: yesAdvanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung   +15 more
wiley   +1 more source

The Neuropsychology of Autistic Spectrum Disorders [PDF]

open access: yesDevelopmental Neuropsychology, 2005
DEVELOPMENTAL NEUROPSYCHOLOGY, 27(3), 307-310 Copyright © 2005, Lawrence Erlbaum Associates, Inc. The Neuropsychology of Autistic Spectrum Disorders Natacha Akshoomoff Department of Psychiatry University of California, San Diego Child and Adolescent Services Research Center Children's Hospital, San Diego This special issue represents the work from ...
openaire   +3 more sources

Automating AI Discovery for Biomedicine Through Knowledge Graphs and Large Language Models Agents

open access: yesAdvanced Intelligent Discovery, EarlyView.
This work proposes a novel framework that automates biomedical discovery by integrating knowledge graphs with multiagent large language models. A biologically aligned graph exploration strategy identifies hidden pathways between biomedical entities, and specialized agents use this pathway to iteratively design AI predictors and wet‐lab validation ...
Naafey Aamer   +3 more
wiley   +1 more source

A Review on Recent Trends of Bioinspired Soft Robotics: Actuators, Control Methods, Materials Selection, Sensors, Challenges, and Future Prospects

open access: yesAdvanced Intelligent Systems, Volume 7, Issue 3, March 2025.
This article reviews the current state of bioinspired soft robotics. The article discusses soft actuators, soft sensors, materials selection, and control methods used in bioinspired soft robotics. It also highlights the challenges and future prospects of this field.
Abhirup Sarker   +2 more
wiley   +1 more source

Wechsler Intelligence Scale for Children-Revised Profiles in Children with Attention Deficit Hyperactivity Disorder: Impact of Comorbid Autistic Traits

open access: yesEurasian Journal of Medicine
Background: This study aimed to identify cognitive differences between children diagnosed with attention deficit hyperactivity disorder (ADHD) with and without comorbid autistic traits by using the Wechsler Intelligence Scale for Children-Revised (WISC ...
Buket Kılıç, Dilek Ünal
doaj   +1 more source

Organic Brain Dysfunction and Autism

open access: yesPediatric Neurology Briefs, 1991
A population-based neurobiological study of 35 children with autistic disorder (AD) and 17 with autistic-like conditions (ALC) is reported from the Department of Child and Adolescent Psychiatry, University of Goteborg, Sweden.
J Gordon Millichap
doaj   +1 more source

Sleep Disturbances in Adults With Tuberous Sclerosis Complex: Influences of Treatment and Clinical Features

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Tuberous sclerosis complex (TSC) is a genetic condition with multisystem neurocutaneous signs, including hamartomas, epilepsy, and neuropsychological difficulties. Although sleep disorders are increasingly recognized in TSC, they remain poorly described in adults.
Kirstin A. Risgaard   +6 more
wiley   +1 more source

Classification of autism spectrum disorder using supervised learning of brain connectivity measures extracted from synchrostates

open access: yes, 2014
Objective. The paper investigates the presence of autism using the functional brain connectivity measures derived from electro-encephalogram (EEG) of children during face perception tasks. Approach.
Oprescu, Ioana-Anastasia   +5 more
core   +1 more source

Autism and ADHD in Tuberous Sclerosis

open access: yesPediatric Neurology Briefs, 1994
In a population-based psychiatric study of 28 patients with tuberous sclerosis (TS) at the University of Goteborg, Sweden, 24 had autistic symptoms and 17 met all DSM-III-R criteria for autistic disorder (AD).
J Gordon Millichap
doaj   +1 more source

Determination of Knowledge of Caregivers about Dietary Practices of Autistic Children

open access: yesBioMedica, 2020
Background and Objective: Autism belongs to a complex neurodevelopmental disorder. The lack of knowledge about dietary practices of autistic caregivers is perceived as the triggering factor of ‘Autistic Spectrum Disorder (ASD).
Maryam Yaseen   +6 more
doaj   +1 more source

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