Results 81 to 90 of about 3,152,180 (364)

Gastrodin Rescues Autistic-Like Phenotypes in Valproic Acid-Induced Animal Model

open access: yesFrontiers in Neurology, 2018
Autism spectrum disorder (ASD) is an immensely challenging developmental disorder characterized by impaired social interaction, restricted/repetitive behavior, and anxiety.
Xiaona Wang   +13 more
doaj   +1 more source

The impact of schizotypy on quality of life among adults with autism spectrum disorder

open access: yesBMC Psychiatry, 2022
Background Autism spectrum disorder (ASD) and schizotypal personality disorder can be difficult to distinguish. Deficits in social relationships and social interaction, present in both conditions, are known to impair quality of life.
Albin Klang   +3 more
doaj   +1 more source

Impaired neurodevelopmental pathways in autism spectrum disorder: a review of signaling mechanisms and crosstalk. [PDF]

open access: yes, 2019
BackgroundThe development of an autistic brain is a highly complex process as evident from the involvement of various genetic and non-genetic factors in the etiology of the autism spectrum disorder (ASD). Despite being a multifactorial neurodevelopmental
Gu, Ran   +5 more
core  

Why Are Autism Spectrum Conditions More Prevalent in Males? [PDF]

open access: yes, 2011
Autism Spectrum Conditions (ASC) are much more common in males, a bias that may offer clues to the etiology of this condition. Although the cause of this bias remains a mystery, we argue that it occurs because ASC is an extreme manifestation of the male ...
Ashwin, Emma   +5 more
core   +4 more sources

Brd4 BD1 Domain Antagonism of MS436 Preserves Blood‐Brain Barrier Integrity via Rnf43/β‐Catenin Signaling Pathway

open access: yesAdvanced Science, EarlyView.
MS436 competitively binds to the BD1 domain of Brd4, thereby suppressing Brd4 induced degradation of tight junction proteins via the Rnf43‐Fzd4‐β‐catenin signaling pathway. Consequently, this attenuation of degradation reduces blood‐brain barrier leakage, leading to an improved overall prognosis after stroke.
Chenxiao Li   +10 more
wiley   +1 more source

The Microbiota Shapes Central Nervous System Myelination in Early Life

open access: yesAdvanced Science, EarlyView.
Gut microbiota shapes brain development by regulating myelination and glial cell maturation in early life. Using germ‐free (GF) mice and zebrafish, this study reveals sex‐ and age‐dependent effects on myelin growth, integrity, and related gene expression.
Caoimhe M. K. Lynch   +13 more
wiley   +1 more source

The clinical characteristics of autistic women with restrictive eating disorders

open access: yesBJPsych Open
Background Autistic women are at high risk of developing restrictive eating disorders (REDs), such as anorexia nervosa. Aims This study provides an overview of the clinical characteristics of autistic women with REDs to (i) enhance understanding of ...
Janina Brede   +8 more
doaj   +1 more source

Dorsal Raphe VIP Neurons Are Critical for Survival‐Oriented Vigilance

open access: yesAdvanced Science, EarlyView.
DRNVIP neurons in mice and primates are strategically positioned to influence the central extended amygdala via feedback loops. They regulate the excitability of PKC‐δ neurons in the ovBNST and CeA through glutamate release. Their ablation heightens activity in these regions, disrupts active‐phase sleep architecture, enhances risk assessment behaviors ...
Adriane Guillaumin   +15 more
wiley   +1 more source

Instruments for augmentative and alternative communication for children with autism spectrum disorder: a systematic review

open access: yesClinics, 2018
New technologies designed to improve the communication of autistic children can also help to promote interaction processes and cognitive and social development. The aim of this study was to analyze the instruments used to improve the communication skills
Jennifer Yohanna Ferreira de Lima Antão   +11 more
doaj   +1 more source

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