Results 81 to 90 of about 172,893 (331)

Instruments for augmentative and alternative communication for children with autism spectrum disorder: a systematic review

open access: yesClinics, 2018
New technologies designed to improve the communication of autistic children can also help to promote interaction processes and cognitive and social development. The aim of this study was to analyze the instruments used to improve the communication skills
Jennifer Yohanna Ferreira de Lima Antão   +11 more
doaj   +1 more source

Adenylyl Cyclase 8 in Dorsal CA1 Neurons Prevents Depressive‐Like Behaviors by Maintaining Neuronal Excitability and Glutamatergic Neurotransmission Through TIP39‐PTH2R Signaling

open access: yesAdvanced Science, EarlyView.
Depression, a prevalent neuropsychiatric disorder with unclear pathogenesis, involves dysfunctional adenylyl cyclase 8 (Adcy8) as a key risk factor. Chronic stress selectively reduces Adcy8 expression in the dorsal CA1 (dCA1) neurons. Depletion of Adcy8 in dCA1 excitatory neurons induces depressive‐like behaviors by impairing neuronal excitability and ...
Zi‐Jie Liu   +14 more
wiley   +1 more source

Impaired neurodevelopmental pathways in autism spectrum disorder: a review of signaling mechanisms and crosstalk. [PDF]

open access: yes, 2019
BackgroundThe development of an autistic brain is a highly complex process as evident from the involvement of various genetic and non-genetic factors in the etiology of the autism spectrum disorder (ASD). Despite being a multifactorial neurodevelopmental
Gu, Ran   +5 more
core  

Altered gut microbiota and short chain fatty acids in Chinese children with autism spectrum disorder

open access: yesScientific Reports, 2019
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is characterized by impairments in social interactions and communication, restricted interests and repetitive behaviors. Several studies report a high prevalence of gastrointestinal (GI)
Simeng Liu   +10 more
doaj   +1 more source

AUTISTIC EPILEPTIFORM REGRESSION (A REVIEW)

open access: yesРусский журнал детской неврологии, 2015
The author represents the review of current scientific literature devoted to autistic epileptiform regression — the special form of autistic disorder, characterized by development of severe communicative disorders in children as a result of continuous ...
L. Yu. Glukhova
doaj   +1 more source

The Neuropsychology of Autistic Spectrum Disorders [PDF]

open access: yesDevelopmental Neuropsychology, 2005
DEVELOPMENTAL NEUROPSYCHOLOGY, 27(3), 307-310 Copyright © 2005, Lawrence Erlbaum Associates, Inc. The Neuropsychology of Autistic Spectrum Disorders Natacha Akshoomoff Department of Psychiatry University of California, San Diego Child and Adolescent Services Research Center Children's Hospital, San Diego This special issue represents the work from ...
openaire   +3 more sources

Induced Proprioceptor and Low‐Threshold Mechanoreceptor Neurons Derived from Human Pluripotent Stem Cells Exhibit Distinct Functional Mechanosensory Properties

open access: yesAdvanced Science, EarlyView.
This study describes derivation of two distinct mechanosensory subpopulations from human pluripotent stem cells using a transcription factor mediated approach. Of significance, functional interrogation of induced mechanosensory subtypes reveal their unique responses to mechanical stimulation in the absence of end‐organs.
Amy J. Hulme   +12 more
wiley   +1 more source

The Gut Microbiota Regulates Motor Deficits via Butyrate in a Gnal+/− Mouse Model of DYT25 Dystonia

open access: yesAdvanced Science, EarlyView.
The present study provides compelling evidence for a modulatory role of the gut microbiota in the pathology of DYT25 dystonia, and butyrate supplementation alleviates the motor deficits of dystonia in Gnal+/− mice. Abstract Dystonia is the third most common movement disorder, following essential tremor and Parkinson's disease. The underlying mechanisms
Jingya Guo   +3 more
wiley   +1 more source

Sex differences in the timing of identification among children and adults with autism spectrum disorders [PDF]

open access: yes, 2013
To examine differences by sex in the timing of identification of individuals with autism spectrum disorders (ASD), survey data were collected in the Netherlands from 2,275 males and females with autistic disorder, Asperger's syndrome and PDD-NOS.
A Klin   +41 more
core   +1 more source

Brd4 BD1 Domain Antagonism of MS436 Preserves Blood‐Brain Barrier Integrity via Rnf43/β‐Catenin Signaling Pathway

open access: yesAdvanced Science, EarlyView.
MS436 competitively binds to the BD1 domain of Brd4, thereby suppressing Brd4 induced degradation of tight junction proteins via the Rnf43‐Fzd4‐β‐catenin signaling pathway. Consequently, this attenuation of degradation reduces blood‐brain barrier leakage, leading to an improved overall prognosis after stroke.
Chenxiao Li   +10 more
wiley   +1 more source

Home - About - Disclaimer - Privacy