Results 61 to 70 of about 230,797 (353)

A Ketogenic Diet and the Treatment of Autism Spectrum Disorder

Frontiers in Pediatrics, 2021
Autism spectrum disorder (ASD) is characterized by stereotyped behavior and deficits in communication and social interaction. There are no curative treatments for children with ASD.
Qinrui Li, Jingjing Liang, Na Fu, Ying Han, J. Qin   +4 more
semanticscholar   +1 more source

The DEC2‐SCN2A Axis is Essential for the Anticonvulsant Effects of Cannabidiol by Modulating Neuronal Plasticity

Advanced Science, EarlyView.
This study identifies DEC2 as a critical transcriptional repressor of Scn2a that directly binds E‐box motifs in its promoter to regulate neuronal plasticity and epileptogenesis. Functional manipulation of DEC2 alters seizure susceptibility in vivo. Cannabidiol enhances this repression, unveiling a novel DEC2‐SCN2A axis underlying its anticonvulsant ...
Huifang Song, Yifan Wang, Lili Wang, Chang Guo, Shiqi Liu, Yi Rong, Jiawen Tian, Chao Peng, Yuying Shao, Zhixiong Ma, Na Li, Jingliang Zhang, Zijun Peng, Xu Yan, Hangwei Fa, Xinyue Ma, Jie Dong, Jinping Ji, Chen Yang, Haocheng Chen, Jing Liang, Qi Sun, Yang Yang, Weining Ma, Zhuo Huang   +24 more
wiley   +1 more source

Schedules for the detection, diagnosis, and assessment of autistic spectrum disorder [PDF]

, 2001

  +8 more sources

Unlocking the Code: Exploring Autism Spectrum Traits among Medical Students through the Lens of Blood Group Phenotypes

Life and Science
Objective: To assess autistic spectrum disorder traits (based on language, social relatedness, sensory-motor discrepancies, and circumscribed interests) prevalence among undergraduates, explore associations with sociodemographic factors and blood group ...
Aiman Farogh Anjum, Noman Sadiq, Warda Hussain, Waqas Ali, Waseem Pasha, Mahjabeen Safdar, Hafsa Zulfiqar Malik, Khadijia Talat, Shoaib Naiyar Hashmi   +8 more
doaj   +1 more source

Focusing on Autism Spectrum Disorder in Xia–Gibbs Syndrome: Description of a Female with High Functioning Autism and Literature Review

Children, 2021
Background: Xia–Gibbs syndrome (XGS) is a rare disorder caused by de novo mutations in the AT-Hook DNA binding motif Containing 1 (AHDC1) gene, which is characterised by a wide spectrum of clinical manifestations, including global developmental delay ...
Stefania Della Vecchia, Roberta Milone, Romina Cagiano, Sara Calderoni, Elisa Santocchi, Rosa Pasquariello, Roberta Battini, Filippo Muratori   +7 more
doaj   +1 more source

A CGG‐Repeat Expansion Mutation in ZNF713 Causes FRA7A: Association with Autistic Spectrum Disorder in Two Families

Human Mutation, 2014
We report de novo occurrence of the 7p11.2 folate‐sensitive fragile site FRA7A in a male with an autistic spectrum disorder (ASD) due to a CGG‐repeat expansion mutation (∼450 repeats) in a 5′ intron of ZNF713. This expanded allele showed hypermethylation
S. Metsu, J. Rainger, Kim Debacker, B. Bernhard, Liesbeth Rooms, D. Grafodatskaya, R. Weksberg, E. Fombonne, Martin S. Taylor, S. Scherer, R. Kooy, D. FitzPatrick   +11 more
semanticscholar   +1 more source

Melatonin: From Pharmacokinetics to Clinical Use in Autism Spectrum Disorder

International Journal of Molecular Sciences, 2021
The role of melatonin has been extensively investigated in pathophysiological conditions, including autism spectrum disorder (ASD). Reduced melatonin secretion has been reported in ASD and led to many clinical trials using immediate-release and prolonged-
Sébastien Lalanne, C. Fougerou-Leurent, G. Anderson, C. Schroder, T. Nir, S. Chokron, R. Delorme, B. Claustrat, É. Bellissant, S. Kermarrec, P. Franco, L. Denis, S. Tordjman   +12 more
semanticscholar   +1 more source

Inhibition of Phosphodiesterase 10A by MP‐10 Rescues Behavioral Deficits and Normalizes Microglial Morphology and Synaptic Pruning in A Mouse Model of FOXP1 Syndrome

Advanced Science, EarlyView.
We demonstrate that Foxp1± mice, modeling FOXP1 haploinsufficiency, exhibit behavioral deficits, striatal neuroinflammatory changes including altered microglial complexity and synaptic pruning, and markedly reduced Pde10a expression. Pde10a inhibition starting immediately after birth restores Foxp1± behavior, microglial morphology, and pruning ...
Henning Fröhlich, Jing Wang, Ferdinand Althammer, Tim Schubert, Nina Kluck, Valery Grinevich, Stefanie Schmitteckert, Christian P. Schaaf, Gudrun A. Rappold   +8 more
wiley   +1 more source

Sleep Deprivation Aggravates Periodontitis Through Trigeminal‐Periodontal Neuroimmune Pathway Mediated by the AChE‐ACh‐α7nAChR Axis

Advanced Science, EarlyView.
Sleep deprivation (SD) exacerbates ligature‐induced periodontitis (LIP) through the trigeminal nerve‐periodontal neuroimmune pathway mediated by the acetylcholinesterase (AChE)‐acetylcholine (ACh)‐α7 nicotinic receptor (α7nAChR) axis. While electroacupuncture (EA) alleviates the condition of LIP combined with SD by activating the α7nAChR.
Kehao Liu, Qi Huang, Mingcong Yang, Ziyu Huang, Kamoran Tuerhong, Yue Zu, Ying Xie, Xuehui Hu, Qianyu Zhang, Ping He, Nannan Huang, Rong Zhang, Yuzhou Li, Sheng Yang   +13 more
wiley   +1 more source

The Melatonin Receptor Agonist Ramelteon Effectively Treats Insomnia and Behavioral Symptoms in Autistic Disorder

Case Reports in Psychiatry, 2014
Children with autism spectrum disorders (ASD), including autistic disorder, frequently suffer from comorbid sleep problems. An altered melatonin rhythm is considered to underlie the impairment in sleep onset and maintenance in ASD.
Kentaro Kawabe, Fumie Horiuchi, Yasunori Oka, Shu-ichi Ueno   +3 more
doaj   +1 more source