Results 61 to 70 of about 61,817 (299)

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

The relationship between autistic traits and the stress of social isolation: Development of an explanatory model

Heliyon
Background: Social isolation can be particularly challenging for individuals with high autistic traits who struggle with social interactions. The COVID-19 pandemic led to increased isolation, exacerbating stress for those who may have difficulty in ...
Min Shao, Shu Luo, Huiling Qian, Xiaoran Li, Zilong Wei, Mingyu Hong, Junyao Wang, Xiong Li, Jing Meng   +8 more
doaj   +1 more source

A longitudinal twin study of the association between childhood autistic traits and psychotic experiences in adolescence [PDF]

, 2015
- Background: This twin study investigated whether autistic traits during childhood were associated with adolescent psychotic experiences. - Methods: Data were collected from a community sample of approximately 5000 twin pairs, which included 32 ...
A Angold, A Ronald, A Ronald, American Psychiatric Association, BJ Crespi, C Brett, C Lord, C Lord, CMA Haworth, Cross-Disorder Group of the Psychiatric Genomics Consortium, D McCarthy, D Wechsler, E Colvert, EB Robinson, EI Bruin de, FJ Scott, G Joshi, HMS Zavos, I Kelleher, I Kelleher, J Williams, JC Raven, JJ Blanchard, JT Wigman, K Dworzynski, KD Gadow, KD Gadow, M McGue, MD Dominguez, MJ Owen, MJ Taylor, OSP Davis, OT Leyfer, P Howlin, PF Sullivan, R Bevan Jones, R Core Team, R Goodman, R Poulton, S Baron-Cohen, S Baron-Cohen, S Curran, S Steinberg, S Sullivan, S Zammit, SE Levy, SM Boker, SM Purcell, TM Laursen, TS Price, V Hallett, WK Silverman   +51 more
core   +1 more source

Challenges and solutions for autism in academic geosciences [PDF]

, 2020
Researcher diversity promotes research excellence. But academia is widely perceived as inaccessible to those who work in non-stereotypical ways, and disabled researchers are consequently chronically under-represented within higher education. The barriers
Johnson, Jessica H., Taylor, Nicola C.
core   +1 more source

Functional Mapping of Neurodevelopmental Disease Pathways to Key Neurodevelopmental Processes Represented in the Developmental Neurotoxicity In Vitro Testing Battery

Advanced Science, EarlyView.
Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska, Kristina Bartmann, Georgea Raad, Mats Schade, Luiz Ladeira, Arif Dönmez, Jördis Klose, Nicolai Görts, Denis Polozij, Lynn‐Christin Saborowski, Farina Bendt, Bernard Staumont, Liesbet Geris, Katharina Koch, Ellen Fritsche   +14 more
wiley   +1 more source

No effect of autistic traits on social attention: evidence based on single-cue and conflicting-cues scenarios

BMC Psychology
Individuals often use others’ gaze and head directions to direct their attention. To investigate the influence of autistic traits on social attention, we conducted two experiments comparing groups with high and low autistic traits in single-cue ...
Airui Chen, Meiyi Wang, Bo Dong
doaj   +1 more source

Autism, the Integrations of 'Difference' and the Origins of Modern Human Behaviour [PDF]

, 2009
It is proposed here that the archaeological evidence for the emergence of 'modern behaviour' (160,000-40,000 bp) can best be explained as the rise of cognitive variation within populations through social mechanisms for integrating 'different minds ...
Spikins, Penny
core   +1 more source

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
wiley   +1 more source

Autistic traits are associated with lower perceived executive function but not poorer executive function task performance in the general population: complementary meta-analytic evidence

Molecular Autism
Background Autistic individuals generally exhibit real-world executive function (EF) difficulties and perform poorly on EF tasks. However, while autistic traits are distributed continuously throughout the general population, the relationships between ...
Michael K. Yeung, Cassie T. Y. Li, Harris C. W. Chung, Tsz-hei Au, Sin-yue Lee, Jieru Bai   +5 more
doaj   +1 more source

The relationship between sensory sensitivity and autistic traits in the general population. [PDF]

, 2012
Individuals with Autism Spectrum Disorders (ASDs) tend to have sensory processing difficulties (Baranek et al. in J Child Psychol Psychiatry 47:591–601, 2006).
A Ben-Sasson, A Bertone, A Shah, A Sutherland, ACL Yu, AJO Whitehouse, AP Bayliss, Ashley E. Robertson, B Auyeung, B Haesen, C Brown, C Cascio, CL Hilton, D Williams, David R. Simmons, DR Simmons, E Austin, E Milne, E Redcay, EAH Hagen Von dem, EB Goldstein, EJ Grinter, EJ Grinter, F Happé, GT Baranek, J Cosbey, J Piven, JF Willott, JK Kern, JK Kern, JN Constantino, JN Constantino, L Bennetto, L Crane, L Mottron, L Mottron, L Wing, M Elsabbagh, M Stewart, M Woodbury-Smith, O Bogdashina, P Looij-Jansen van de, PJ Jastreboff, RA Hoekstra, RA Hoekstra, RC Wu, RSE Hurley, RSP Jones, S Baron-Cohen, S Khalfa, S Wheelwright, SR Leekam, T Grandin, T Tavassoli   +53 more
core   +3 more sources