Results 71 to 80 of about 36,515 (278)
Advanced Science, EarlyView.CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He +17 more
wiley +1 more source
Advanced Science, EarlyView.Mid‐infrared optoacoustic microscopy (MiROM) acquires lipid‐ and protein‐ associated vibrational contrast in intact fat tissue without dyes, preserving native tissue architecture. Through lateral and axial segmentation, MiROM tracks intrinsic intracellular changes during postnatal remodeling. A quantitative spatial analysis tool (Q‐SAT) maps white‐ and
Myeongseop Kim +7 more
wiley +1 more source
Modular assembly of chiral multisubstituted tetrahydropyrans through a cascade asymmetric aldehyde allylboration/oxa-cyclization by a chiral phosphoric acid [PDF]
Considering the structural importance of 2,6-disubstituted and 2,2,6-trisubstituted tetrahydropyran motifs, two novel types of cascade reactions have been developed to address the challenges of synthetic efficiency, high stereoselectivity and ...
He, Bo Jun +8 more
core +2 more sources
Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy
Advanced Science, EarlyView.Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong +5 more
wiley +1 more source
Zhileng xuebao, 2006 The model was presented to investigate the performance of Auto-cascade Absorption Refrigeration Cycle(ACAR) using R32+R134a/DMF as working pairs in this study.The effects of the factors such as composition of working pairs,generation temperature ...
陈光明, 房杉, 孟祥锋
doaj +2 more sources
Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay
Advanced Science, EarlyView.This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao +6 more
wiley +1 more source
Heating Performance Analysis of a Geothermal Heat Pump Working with Different Zeotropic and Azeotropic Mixtures [PDF]
, 2018 The aim of the paper is to examine the possibility of application of the spreadsheet calculator and Reference Fluid Thermodynamic and Transport Properties database to a thermodynamic process.
Robert Bedoić, Veljko Filipan
core +3 more sources
GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy
Advanced Science, EarlyView.Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu +11 more
wiley +1 more source
Performance assessment on a modified precision refrigeration cycle using low GWP mixtures
Case Studies in Thermal EngineeringRecently, with the increasing worldwide demand for low-temperature freezers, applying natural working medium hydro-carbon refrigerants for them has been widely concerned.
Lingeng Zou, Ye Liu, Qinghua Chen
doaj +1 more source
Energy and exergy analysis of a modified three-stage auto-cascade refrigeration cycle using low-GWP refrigerants for sustainable development. [PDF]
J Therm Anal Calorim, 2023 Qin Y, Li N, Zhang H, Liu B.
europepmc +1 more source