Autoantigen mRNA‐LNP Vaccination Drives Therapeutic Efficacy in Preclinical Models for Autoimmunity
Advanced Science, EarlyView.Systemic and intramuscular delivery of autoantigen mRNA via lipid nanoparticles reprograms antigen‐presenting cells toward a mature, homeostatic state, driving antigen‐specific T cell exhaustion and providing therapeutic efficacy across autoimmune disease models.
Paulien Baeten +30 more
wiley +1 more source
Quantum Information Theory on Sparse Wave Functions and Applications for Quantum Chemistry. [PDF]
J Phys Chem AMateria D, Ratini L, Guidoni L.
europepmc +1 more source
Advanced Science, EarlyView.Cartilage injury promotes local fibrinogen deposition, which accelerates monosodium urate crystallization and activates integrin‐mediated matrix‐degradation. This self‐amplifying cycle drives gout‐related cartilage erosion. Disrupting fibrinogen deposition or restoring the cartilage barrier could interrupt this vicious cycle.
Hanlin Xu +7 more
wiley +1 more source
PromptSeg: An End-to-End Universal Medical Image Segmentation Method via Visual Prompts. [PDF]
Entropy (Basel)Zhao M, Wang B, Shi J, An H.
europepmc +1 more source
A Generative Neuro‐Symbolic AI for Protein Sequence Design
Advanced Science, EarlyView.We introduce EffieDes, a neuro‐symbolic framework coupling deep learning‐based fitness landscape parameterization with exact automated reasoning. Unlike greedy sampling, EffieDes identifies sequences that globally optimize fitness while satisfying intricate design constraints.
Marianne Defresne +12 more
wiley +1 more source
Building MCP-native hierarchical AI scientist ecosystems: a perspective on scaling multi-agent scientific discovery. [PDF]
Front Artif IntellYue L, Ko CY, Chen PY, Di S, Pan S.
europepmc +1 more source
Artificial Host‐Guest Recognition Directs Glycometabolically Engineered Macrophages to Tumors
Advanced Science, EarlyView.Glycoengineered supramolecular macrophages (GSAR‐M) are developed using glycometabolic labeling for bioorthogonal host‐guest tumor targeting. This engineering approach unexpectedly enhances macrophage migration, phagocytosis, and pseudopodia formation. Consequently, GSAR‐M demonstrate robust tumor‐targeting specificity, effectively arrest tumor growth,
Zhiqing Yang +8 more
wiley +1 more source
From chemistry to cognition: the adaptive origins of consciousness under constraint. [PDF]
Front NeurosciStibel J.
europepmc +1 more source
Advanced Science, EarlyView.A serum‐free, air–liquid interface organotypic slice culture model preserves human post‐mortem corpus callosum tissue, successfully recovering from slicing trauma to reflect the donor's underlying disease state. Pairing label‐free Coherent anti‐Stokes Raman scattering (CARS) microscopy with k‐means clustering enables objective, high‐resolution ...
Kasra Roya‐Kouchaki +5 more
wiley +1 more source
Physical inactivity in preclinical Alzheimer's disease: Risk factor, early symptom, or both? [PDF]
Alzheimers Dement (N Y)Zhao J, Li X, Wu M, Zhang Z.
europepmc +1 more source