Results 171 to 180 of about 5,372 (258)

Amyloid‐Induced Network Resilience and Collapse in Alzheimer's Disease: Insights From Computational Modeling

European Journal of Neuroscience, Volume 64, Issue 8, October 2026.
We present a multiscale computational model linking amyloid‐beta accumulation to brain network collapse in Alzheimer's disease. The spectral radius serves as an early‐warning biomarker, anticipating structural collapse by ~47 months. Progressive synaptic degradation drives a transition from synchronized activity through functional subpopulations to ...
Ediline L. F. Nguessap, Damien Depannemaecker, Fernando F. Ferreira   +2 more
wiley   +1 more source

Autocatalytic Reaction between HCN and Cysteamine Produces Hydrophobic, Catalytic, Liquid Compartments. [PDF]

J Am Chem Soc
Novichkov AI, Diskin-Posner Y, Shimon LJW, Leitus G, Flamm C, Semenov SN.   +5 more
europepmc   +1 more source

Normal thromboelastography with a markedly prolonged activated partial thromboplastin time in severe prekallikrein deficiency: Implications for perioperative hemostatic assessment

Transfusion, Volume 66, Issue 10, Page 2031-2036, October 2026.
Abstract Background Prekallikrein (PK) deficiency is a rare contact factor deficiency that can markedly prolong the activated partial thromboplastin time (aPTT) without a bleeding phenotype. Because viscoelastic hemostatic assays also rely on contact activation, their behavior in severe PK deficiency is relevant to perioperative evaluation of isolated ...
Jeremy W. Jacobs, Anton Matafonov, Patricia G. Baxter, Qiufang Cheng, Garrett S. Booth, Deva Sharma, Benjamin F. Tillman, David Gailani   +7 more
wiley   +1 more source

Light-Driven Competitive Selection in a Protein-Catalyzed Dissipative Peptide Replication. [PDF]

Angew Chem Int Ed Engl
Bartus É, Wéber E, Tököli A, Bogár F, Mohamed MRF, Kecskeméti G, Szabó Z, Kele Z, Perczel A, Gadanecz M, Orgován Z, Keserű GM, Martinek TA.   +12 more
europepmc   +1 more source

Mechanistic analysis and kinetic profiling of Soai's asymmetric autocatalysis for pyridyl and pyrimidyl substrates. [PDF]

Nat Commun
Möhler P, Betzenbichler G, Huber L, Siegle AF, Trapp O.   +4 more
europepmc   +1 more source

Evolutionary features in a minimal physical system: Diversity, selection, growth, inheritance, and adaptation. [PDF]

Proc Natl Acad Sci U S A
Bunin G, Rivoire O.
europepmc   +1 more source

The Asymmetric Self-Replicative Alkylation of N-Arylaldimines Using Organolithium Reagents. [PDF]

Chemistry
Hagelschuer A, Visser P, Feringa BL.
europepmc   +1 more source

Thermodynamic consistency of autocatalytic cycles. [PDF]

Proc Natl Acad Sci U S A
Kosc T, Kuperberg D, Rajon E, Charlat S.
europepmc   +1 more source

Compositional memory matters for early molecular systems. [PDF]

Proc Natl Acad Sci U S A
Ledoux B, Kuwabara R, Ichihashi N, Mizuuchi R, Lacoste D.   +4 more
europepmc   +1 more source

The Formose Reaction with SO₂: A Computational Study. [PDF]

Life (Basel)
Sisson EM, Kua J.
europepmc   +1 more source