Results 31 to 40 of about 167,606 (304)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Low-void polyimide resins for autoclave processing [PDF]
, 1972 Development of an advanced A-type polyimide, which can be used to produce autoclave molded, low-void content composites suitable for use at temperatures up to 316 C is reported.
Jones, R. J., Vaughan, R. W.
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 1995 The batch reaction of polyvinyl chloride (PVC) in a pressure autoclave is modelled by considering the various mechanisms for conversion from vinyl chloride monomer (VCM) to the polymer during the middle phase of the industrial process.
Carnie, S., White, L.
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Bioreactor design from an Obsolete Autoclave
Tecnología en Marcha, 2014 One of the known methodologies for solid waste treatment is bacterial decomposition in a controlled environment, under special and anaerobic conditions, inside an equipment called bioreactor.
Teresa Salazar-Rojas +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Design of Tranilast-Loaded Cation-Type Contact Lens for Sustainable Ocular Drug Delivery
PharmaceuticsObjectives: This study evaluated the design of a sustained-release contact lens (CL) device loading tranilast (TRA) and determined the usefulness of these CLs in Japanese albino rabbits.
Toru Matsunaga +7 more
doaj +1 more source
Optimisation of work flow [PDF]
, 1997 AeroSpace Technologies of Australia (ASTA) is a supplier of aircraft components for several of the world's major aircraft manufacturers. Its anticipation of a substantial increase in demand has led to concern as to its ability to satisfy customer imposed
Beaumont, N., Panton, D.M.
core
Requirement verification in simulation-based automation testing
, 2016 The emergence of the Industrial Internet results in an increasing number of complicated temporal interdependencies between automation systems and the processes to be controlled.
Karhela, Tommi +4 more
core +1 more source