Results 231 to 240 of about 91,538 (308)

Precision Mapping of Retinal Disease: Identification of Differential Progression Trajectories via Imaging Phenomics

iMetaMed, EarlyView.
Applying single‐cell RNA‐seq techniques to large‐scale clinical phenotypic data enables the discovery of differential disease progression trajectories and the construction of data‐driven progression scores. These can then be integrated into precision medicine studies to investigate the drivers of patient‐specific disease outcomes. ABSTRACT We propose a
Christian Anderson, Liam Scott, Irene Leung, Ferenc Sallo, Catherine Egan, Tunde Peto, The MacTel Consortium, Melanie Bahlo, Martin Friedlander, Simone Tzaridis, Lea Scheppke, Roberto Bonelli   +11 more
wiley   +1 more source

DELETION INVOLVING EXON 18 OF RPGRIP1 IS a MAJOR CAUSE OF ACHROMATOPSIA. [PDF]

Retina
Inooka T, Mizobuchi K, Hayashi T, Suga A, Tsunoda K, Kuniyoshi K, Kondo H, Ota J, Kominami T, Yoshitake K, Minematsu N, Iwata T, Kondo M, Nishiguchi KM, Ueno S.   +14 more
europepmc   +1 more source

Immune Checkpoint Inhibitors Induce Intestinal Epithelial Injury and a Senescence‐Like Phenotype

iNew Medicine, EarlyView.
ICI treatment promotes the infiltration of activated immune cells into the intestinal mucosa. This inflammatory microenvironment is associated with significant epithelial injury, characterized by the disruption of the epithelial barrier, the depletion of specialized secretory cell lineages, and the induction of a premature senescence phenotype ...
Juan Wang, Shuang Wu, Shuangbiao Wei, Weizhen Xiang, Jianshang Huang, Lei Xiong, Hua Wang, Li Zuo   +7 more
wiley   +1 more source

Spectrally Resolved Fundus Autofluorescence as a Biomarker of Retinal Metabolic Integrity in Intermediate and Atrophic AMD. [PDF]

Invest Ophthalmol Vis Sci
Vujosevic S, Zanzottera E, Brotto L, Piccoli G, Alovisi C, Bucceri V, Rui C, Poletti E, Brambilla M, Coppola M, Nucci P, Chakravarthy U.   +11 more
europepmc   +1 more source

Organoid Imaging: Beyond Depth, Toward Function and Standards

iRADIOLOGY, EarlyView.
Rethinking priorities in organoid imaging: from depth to function and standardization. This article illustrates the current status, key issues, proposed solutions, and future direction of organoid imaging. ABSTRACT Despite recent achievements in organoid models that recapitulate key aspects of human development and disease, a deceptively simple ...
Jing Wang, Peili Cen, Ziyun Fang, Hong Zhang   +3 more
wiley   +1 more source

Clinical Applications and Diagnostic Performance of Adjunctive Light-Based Optical Technologies in Oral Potentially Malignant Disorders and Squamous Cell Carcinoma: A Systematic Review. [PDF]

J Clin Med
Paliga D, Kronenberg M, Pihut M, Pietrzko M, Skaba D, Wiench R.   +5 more
europepmc   +1 more source

Detecting Antibiotic Resistance in Strains of Selected Gram‐Negative Bacterial Species Using Raman Spectroscopy

Journal of Raman Spectroscopy, EarlyView.
Raman spectroscopy successfully identified antibiotic‐resistant Gram‐negative strains. Resistant strains of four bacterial species were discriminated from sensitive ones with 99.1% accuracy using PLS regression. The method allows for rapid, label‐free detection of antibiotic resistance.
Fernanda Sant Ana de Siqueira e Oliveira, Adriano Moraes da Silva, Marcos Tadeu T. Pacheco, Landulfo Silveira Jr.   +3 more
wiley   +1 more source

Cell-MICS: Detecting Immune Cells With Label-Free Two-Photon Autofluorescence and Deep Learning. [PDF]

J Biophotonics
Kreiss L, Chaware A, Roohian M, Lemire S, Thoma OM, Carlé B, Waldner M, Schürmann S, Friedrich O, Horstmeyer R.   +9 more
europepmc   +1 more source

Sodium sulfite can reliably induce chemical hypoxia without toxic effects in the model sea anemone species, Exaiptasia diaphana

Limnology and Oceanography: Methods, EarlyView.
Abstract Climate change is accelerating the deoxygenation of aquatic ecosystems, so understanding its effects on biological processes is increasingly critical. An emerging method for inducing hypoxia during experimentation utilizes sodium sulfite (SSI) to scavenge oxygen; however, it remains unclear if hypoxia‐inducing concentrations of SSI are toxic ...
Zhen Qin, Lorenzo Vassura, Bianca A. Parodi, Elise M. J. Laetz   +3 more
wiley   +1 more source

Autofluorescence enhances intraoperative detection of parathyroid glands: a single-center comparative study. [PDF]

Front Endocrinol (Lausanne)
Dubuis JB, Meyer J, Mavromati M, Leboulleux S, Triponez F, Demarchi MS.   +5 more
europepmc   +1 more source