Results 231 to 240 of about 610,115 (295)

Microbial Biosensor for Sensing and Treatment of Intestinal Inflammation

Advanced Science, EarlyView.
The engineered calprotectin biosensor detects gut inflammation, processes the signal through genetic regulation, and responds by expressing the reporter sfGFP and the therapeutic protein secIL10. This dual functionality enables the engineered biosensor not only to sense but also to mitigate gut inflammation, highlighting its potential for disease ...
Duolong Zhu, Jeffrey Galley, Jason Pizzini, Elena Musteata, Martin V. Douglas, Walter J. Chazin, Eric P. Skaar, Jeffrey J. Tabor, Robert A. Britton   +8 more
wiley   +1 more source

Diagnosis and Management of Autoimmune Hepatitis After Hepatitis A in a Young Woman. [PDF]

Am J Case Rep
Patel S, Dixon C, Chokshi N, Giraldo S, Thiriveedi M, Dailey V.   +5 more
europepmc   +1 more source

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source

The Challenging Management of Rheumatoid Arthritis Overlapping With Graves' Disease in a Young Male: A Case Report. [PDF]

Clin Case Rep
Hamsho S, Aldolly A, Alaswad M.
europepmc   +1 more source

IMMUNOGENETIC DETECTION OF B LOCUS GENOTYPES IN CHICKENS WITH AUTOIMMUNE THYROIDITIS

, 1973
Larry D. Bacon, Joseph H. Kite, NOEL IT. ROSE   +2 more
openalex   +1 more source

Inhalable Artificial Polymeric Nucleases Degrading Neutrophil Extracellular Trap‐DNAs and Alleviating Pulmonary Fibrosis

Advanced Science, EarlyView.
Pulmonary fibrosis (PF) is promoted by NETs that induce fibroblast activation. PEG‐PIm, a polymeric artificial DNase is reported that efficiently degrades NET‐DNA via phosphodiester bond hydrolysis. Inhalation of PEG‐PIm in a mouse PF model prevents fibroblast activation and fibrosis progression, offering a promising therapeutic strategy for NET ...
Yibo Du, Chenxu Zhu, Ruifeng Wang, Shi Chen, Chuang Li, Defang OuYang, Lixin Liu, Yongming Chen   +7 more
wiley   +1 more source

Pyroptosis‐Inducing Platinum(IV) Prodrugs via GSDME Pathway for Chemoimmunotherapy and Metastasis Inhibition in Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
Three PtIV prodrugs MRP, DRP, and HRP are designed to induce pyroptosis in low GSDME‐expressing tumor cells via the Caspase‐3/GSDME pathway. By relaxing chromatin and reactivating GSDME, HRP can effectively induce pyroptosis, enhance pro‐inflammatory cytokine production, and exhibit potent antitumor effects.
Xinda Yang, Chuansheng Xu, Youliang Zeng, Chunhui Wang, Yan Gao, Jie Ding, Sirui Chen, Yuheng Pan, Xin Zhang, Zongwan Mao, Shuo Shi   +10 more
wiley   +1 more source

Concomitant anti-CGRP and immunomodulatory treatments in patients with migraine: towards integrated management strategies. [PDF]

J Neurol
García-Castillo MC, Sierra-Mencía Á, Caronna E, Toledo-Alfocea D, Jaimes A, Urtiaga S, Casas-Limón J, Muñoz-Vendrell A, Santos-Lasaosa S, García Martín V, Martín Ávila G, Polanco M, Villar-Martínez MD, Trevino-Peinado C, Rubio-Flores L, Sánchez-Soblechero A, Portocarrero Sánchez L, Luque-Buzo E, Lozano-Ros A, Gago-Veiga AB, Díaz-De-Terán J, Recio García A, Canales Rodríguez J, Gómez García A, González Salaices M, Campoy S, Mínguez-Olaondo A, Maniataki S, González-Quintanilla V, Porta-Etessam J, Cuadrado ML, Guerrero Peral ÁL, Pozo-Rosich P, Rodríguez-Vico J, Huerta-Villanueva M, Pascual J, Goadsby PJ, Gonzalez-Martinez A.   +37 more
europepmc   +1 more source

Degradation of acetylcholine receptor in diaphragms of rats with experimental autoimmune myasthenia gravis.

, 1979
John P. Merlie, Stephen F. Heinemann, Brett Einarson, Jon Lindstrom   +3 more
openalex   +1 more source

PRMT3‐Mediated H4R3me2a Promotes Primary Age‐Related Tauopathy by Driving Tau Hyperphosphorylation in Neuron

Advanced Science, EarlyView.
This study identifies PRMT3‐mediated H4R3me2a as a critical driver of tau hyperphosphorylation in primary age‐related tauopathy. Mechanistic insights reveal that the PRMT3/H4R3me2a/miR‐448 axis suppresses IGF1R expression via epigenetic regulation, further dysregulating the PI3K/AKT/GSK3β pathway.
Haotian Liu, Xinnan Liu, Fengyuan Tian, Yashuang Chen, Jingying Li, Xue Wang, Wenying Qiu, Xia Wang, Chao Ma, Wei Ge   +9 more
wiley   +1 more source