Results 71 to 80 of about 859,408 (306)
Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy
FEBS Letters, EarlyView.The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley +1 more source
Treatment Side Effects and Associated Autoimmune Diseases
, 2011 A wide variety of immunosuppressants and immunomodulators have been used to treat autoimmune hepatitis. Prednisone or prednisolone, alone or in combination with azathioprine is the treatment mainstay, limited mostly by the development of drug toxicity ...
Cynthia Levy, Levy, Cynthia
core +1 more source
PANoptosis in the pathogenesis of myelodysplastic syndromes
Molecular Oncology, EarlyView.PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla +4 more
wiley +1 more source
Drug Delivery, 2017 Anaplastic carcinoma of the thyroid (ATC) is a lethal human malignant cancer with median survival of 6 months. To date, no treatment has substantially changed its course, which makes urgent need for the development of novel drugs or novel formulations ...
Casimiro Luca Gigliotti +17 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Health Science ReportsBackground and Aims Although the development of acne is influenced by a range of factors, emerging research suggests that dietary choices may also play a role in acne management.
Zeinab Aryanian +6 more
doaj +1 more source
Cell & Bioscience, 2022 Background Research on spatiotemporal gene landscape can provide insights into the spatial characteristics of human kidney development and facilitate kidney organoid cultivation.
Hongwei Wu +12 more
doaj +1 more source
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Pemphigus Vulgaris Activity Score and Assessment of Convergent Validity
Acta Medica Iranica, 2013 Pemphigus is a rare autoimmune blistering disease with different phenotypes. The evaluation of therapeutic interventions requires a reliable, valid and feasible to use measurement.
Cheyda Chams-Davatchi +6 more
doaj
Non-coronary cardiac manifestations of systemic lupus erythematosus in adults: a comparative study
The Pan African Medical Journal, 2019 Cardiac manifestations develop in the majority of patients with systemic lupus erythematosus (SLE) at some time during the course of their disease.
Sameh Sayhi +7 more
doaj +1 more source