Results 71 to 80 of about 763,556 (317)

Integrating spatial transcriptomics with single-cell transcriptomics reveals a spatiotemporal gene landscape of the human developing kidney

Cell & Bioscience, 2022
Background Research on spatiotemporal gene landscape can provide insights into the spatial characteristics of human kidney development and facilitate kidney organoid cultivation.
Hongwei Wu, Fanna Liu, Yu Shangguan, Yane Yang, Wei Shi, Wenlong Hu, Zhipeng Zeng, Nan Hu, Xinzhou Zhang, Berthold Hocher, Donge Tang, Lianghong Yin, Yong Dai   +12 more
doaj   +1 more source

Thrombosis and Hyperinflammation in COVID-19 Acute Phase Are Related to Anti-Phosphatidylserine and Anti-Phosphatidylinositol Antibody Positivity

Biomedicines, 2023
Antiphospholipid antibodies (APLA) are strongly associated with thrombosis seen in patients with antiphospholipid syndrome. In COVID-19, thrombosis has been observed as one of the main comorbidities.
Jaume Alijotas-Reig, Ariadna Anunciación-Llunell, Stephanie Morales-Pérez, Jaume Trapé, Enrique Esteve-Valverde, Francesc Miro-Mur   +5 more
doaj   +1 more source

Autoimmunity: The nuclear arsenal of autoimmunity [PDF]

Immunology & Cell Biology, 2007
An exciting new work recently published in Nature Immunology shows that an iconic molecule should not get all the blame for carrying out the dirty work of autoimmunity ...
openaire   +2 more sources

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Autoimmune and autoinflammatory mechanisms in uveitis

, 2014
The eye, as currently viewed, is neither immunologically ignorant nor sequestered from the systemic environment. The eye utilises distinct immunoregulatory mechanisms to preserve tissue and cellular function in the face of immune-mediated insult ...
Dick, Andrew D, Robert B. Nussenblatt, Wei, Lai, Dick, AD, Andrew D. Dick, Nicholson, Lindsay B, Chan, Chi-Chao, Lindsay B. Nicholson, Sen, H Nida, Wei, L, H. Nida Sen, Nussenblatt, RB, Nicholson, LB, Chi-Chao Chan, Lee, RW, Nussenblatt, Robert B, Sen, HN, Richard W. Lee, Lai Wei, Chan, CC, Lee, Richard W   +20 more
core   +1 more source

The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP-lpr/lpr mice [PDF]

, 1996
MRL/MP-lpr/lpr (MRL/lpr) mice develop a spontaneous autoimmune disease. Serum from these mice contained significantly higher concentrations of nitrite/nitrate than serum from age-matched control MRL/MP-+/+ (MRL/+), BALB/c or CBA/6J mice.
Liew, F. W., G J Feng, Stott, D. I., Huang, Fangping, Feng, G.J., D I Stott, Feng, Gui Jie, Huang, F.P., G Lindop, Stott, David Ian, F Y Liew, Liew, F.Y., Lindop, George B M, F P Huang, Lindop, G., Huang, F. P., Liew, Fooyew, Stott, D.I., Feng, Guijie   +18 more
core   +1 more source

Urinary metabolomic biomarker candidates for skeletal muscle wasting in patients with rheumatoid arthritis

Journal of Cachexia, Sarcopenia and Muscle, 2023
Background Rheumatoid arthritis (RA) is an autoimmune disease that affects the joints, leading to chronic synovial inflammation and local tissue destruction. Extra‐articular manifestations may also occur, such as changes in body composition.
Marianne S. Oliveira, Rafaela C.E. Santo, Jordana M.S. Silva, Paulo V.G. Alabarse, Claiton V. Brenol, Steve P. Young, Ricardo M. Xavier   +6 more
doaj   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source

Novel associations for hypothyroidism include known autoimmune risk loci

, 2011
Hypothyroidism is the most common thyroid disorder, affecting about 5% of the general population. Here we present the first large genome-wide association study of hypothyroidism, in 2,564 cases and 24,448 controls from the customer base of 23andMe, Inc.,
Amy K. Kiefer (160836), David A. Hinds (128908), Eriksson Nicholas, Kiefer Amy K., Joanna L. Mountain (173244), Joyce Y. Tung (160861), Francke Uta, Chuong B. Do, Nicholas Eriksson (54415), Uta Francke (41540), Hinds David A., David A Hinds, Tung Joyce Y., Joyce Y Tung, Nicholas Eriksson, Amy K Kiefer, Joanna L Mountain, Chuong B. Do (22097), Mountain Joanna L., Joanna L. Mountain, Do Chuong B., Uta Francke, Joyce Y. Tung, Chuong B Do, Amy K. Kiefer, David A. Hinds   +25 more
core   +1 more source

Equine recurrent uveitis - A spontaneous horse model of uveitis [PDF]

, 2008
Equine recurrent uveitis (ERU) is an autoimmune disease that occurs with a high prevalence (10%) in horses. ERU represents the only reliable spontaneous model for human autoimmune uveitis.
Amann, B., Amann, Barbara, Raith, A., Ueffing, Marius, Pompetzki, D., Schmalzl, T., Altmann, Frank, Hauck, S.M., Ueffing, M., Pompetzki, Dirk, Schmalzl, Thomas, Stangassinger, Manfred, Stangassinger, M., Altmann, F., Deeg, Cornelia A., Hauck, Stefanie M., Raith, Albert, Deeg, C.A.   +17 more
core   +1 more source