Results 81 to 90 of about 627,005 (317)

Dysregulation of T Follicular Helper and Regulatory Cells in IRF5-SLE Homozygous Risk Carriers and Systemic Lupus Erythematosus Patients

Cells
T follicular helper (Tfh) and T follicular regulatory cells (Tfr) are required for antibody production and are dysregulated in SLE. Genetic variants within or near interferon regulatory factor 5 (IRF5) are associated with SLE risk. We previously reported
Bharati Matta, Lydia Thomas, Vinay Sharma, Betsy J. Barnes   +3 more
doaj   +1 more source

Association between red cell distribution width and response to methotrexate in rheumatoid arthritis

Reumatismo, 2020
Red cell distribution width (RDW) is an unconventional biomarker of inflammation. We aimed to explore its role as a predictor of treatment response in rheumatoid arthritis (RA).
M. Bellan, D. Soddu, E. Zecca, A. Croce, R. Bonometti, R. Pedrazzoli, D. Sola, C. Rigamonti, L.M. Castello, G.C. Avanzi, M. Pirisi, P.P. Sainaghi   +11 more
doaj   +1 more source

Autoimmune disease re-examined in light of metagenomic concepts

, 2012
The concept of autoantibodies was developed at a time when, due to the limitations of culturebased techniques, the human body was considered to be largely sterile.
Proal, Amy
core  

Unraveling the genetics of lymphocytic thyroiditis using the dog as a model [PDF]

, 2012
The domestic dog, with its unique genetic structure formed by domestication and recent breed creation, has been proven to be an excellent model for mapping disease genes. In this thesis, we use the dog as a model to investigate the prevalence and genetic
Sundberg, Katarina
core  

Neuroprotection in a Novel Mouse Model of Multiple Sclerosis [PDF]

, 2013
Multiple sclerosis is an immune-mediated, demyelinating and neurodegenerative disease that currently lacks any neuroprotective treatments. Innovative neuroprotective trial designs are required to hasten the translational process of drug development.
Coffey, P, Baker, MD, Coffey Pete, Jackson, SJ, Gavin Giovannoni, Baker David, Samuel J. Jackson (468645), Zubair Ahmed (9352), Jackson Samuel J., Zubair Ahmed, Ahmed, Z, Mark D Baker, Pete Coffey (422262), David Baker, Samuel J Jackson, Gavin Giovannoni (125820), Giovannoni Gavin, Munro Peter, Ahmed Zubair, Pete Coffey, David Baker (11642), Peter Munro (479715), Peter Munro, Lidster Katie, Baker Mark D., Baker, D, Lidster, K, Mark D. Baker (146531), Katie Lidster, Munro, P, Katie Lidster (479714), Giovannoni, G   +31 more
core   +1 more source

Autoimmune polyendocrine syndromes associated with autoimmune rheumatic diseases

, 2023
Autoimmune polyendocrine syndromes (APSs), also called autoimmune polyglandular syndromes, are a group of autoimmune diseases characterized by the co-occurrence of dysfunctions of several (at least two) endocrine glands.
Katarzyna Suchta, Małgorzata Stasiek, Katarzyna Jankowska, Piotr Dudek   +3 more
core   +1 more source

A Systematic Review and Meta‐Analysis of the Recurrence of Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune encephalitis (AE) is a disease with a potential for recurrence, and patients receive immunotherapy to prevent it. However, there is no consensus on the duration of immunotherapy. This study aimed to determine the recurrence rate and identify the risk factors for AE to provide guidance on the duration of immunotherapy ...
Shangkai Bai, Sen Zhang, Haipei Zhang, Yating Zhang, Junhong Guo, Xiaoyan Yang   +5 more
wiley   +1 more source

Priming of rat bone marrow-derived mesenchymal stem cells with curcumin induces an anti-inflammatory M2 phenotype in J774A.1 macrophage cell line

BMC Complementary Medicine and Therapies
Context In recent years, several strategies have been used to enhance mesenchymal stem cells’ (MSCs) immunomodulatory and therapeutic potential. Curcumin (Cur), the main active component of turmeric from the Curcuma longa plant, might improve the ...
Gholamreza Daryabor, Nasim Kheshtchin, Seyede Zahra Hashemi, Fatemeh Rezaei Kahmini, Nasser Gholijani   +4 more
doaj   +1 more source

Omics approaches open new horizons in major depressive disorder: from biomarkers to precision medicine

Frontiers in Psychiatry
Major depressive disorder (MDD) is a recurrent episodic mood disorder that represents the third leading cause of disability worldwide. In MDD, several factors can simultaneously contribute to its development, which complicates its diagnosis. According to
Fabiola Stolfi, Fabiola Stolfi, Hugo Abreu, Hugo Abreu, Riccardo Sinella, Riccardo Sinella, Sara Nembrini, Sara Nembrini, Sara Centonze, Sara Centonze, Virginia Landra, Claudio Brasso, Giuseppe Cappellano, Giuseppe Cappellano, Paola Rocca, Annalisa Chiocchetti, Annalisa Chiocchetti   +16 more
doaj   +1 more source

Innate Immune Reprogramming Mediated by Endogenous Retroelement Dysregulation Drives Multiple Sclerosis Progression

Annals of Clinical and Translational Neurology, EarlyView.
Epigenetic reprogramming in hematopoietic stem and progenitor cells (HSPCs) and downstream myeloid cells, mediated by H3.3 downregulation and endogenous retroelement (ERE) overexpression, contributes to the progression of multiple sclerosis (MS). ABSTRACT Background Skewed myelopoiesis in the bone marrow has been identified as a key driver of multiple ...
Li‐Mei Xiao, Qiu‐Ping Zhao, Run‐Yun Li, Wei Chen, Huan‐Huan Song, Wan‐Jin Chen, Ying Fu   +6 more
wiley   +1 more source