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Leptin in autoimmune diseases

Metabolism, 2007
The past twenty years of research on leptin has provided crucial information on the link between metabolic state and immune system function. Adipocytes influence not only the endocrine system but also the immune response, through several cytokine-like mediators known as adipokines, which include leptin.
Procaccini Claudio   +3 more
openaire   +8 more sources

Celiac Disease and Autoimmunity

Journal of Pediatric Gastroenterology and Nutrition, 2014
ABSTRACTCeliac disease (CD) has a multifactorial etiology with complex genetics and frequently occurs in association with other autoimmune disorders. Even though triggered by a dietary antigen, it shows many autoimmune features, the most peculiar being the presence of high titers of anti‐tissue transglutaminase 2 autoantibodies, produced in the small ...
TRONCONE, RICCARDO, DISCEPOLO, VALENTINA
openaire   +3 more sources

The Autoimmune Diseases

JAMA: The Journal of the American Medical Association, 1987
SINCE the earliest descriptions of the immune system, the ability of an individual to react to a wide variety of foreign and endogenous antigens, while not responding to one's own self, has intrigued researchers. The first descriptions of autoimmune phenomena in the early 1900s aroused sufficient anxiety to cause Ehrlich to coin the term "horror ...
openaire   +3 more sources

Seronegative Autoimmune Diseases

Annals of the New York Academy of Sciences, 2009
A close relationship exists between autoimmunity and autoantibodies; despite this, some patients are persistently negative for disease‐specific autoantibodies. These conditions have been defined as seronegative autoimmune diseases. Although the prevalence of seronegative autoimmune diseases is low, they may represent a practical problem because they ...
ALESSANDRI, cristiano   +5 more
openaire   +4 more sources

Autoimmunity and Celiac Disease

Mini-Reviews in Medicinal Chemistry, 2008
In celiac disease (CD), abnormal immune-mediated responses follow ingestion of gluten. Although the triggering agent is a dietary protein, the disease has autoimmune components because of the presence of autoantibodies and its association with autoimmune conditions.
GIANFRANI C   +2 more
openaire   +5 more sources

Infection, autoimmunity and autoimmune disease

1996
Studies of the immune response of mammals to infectious agents have revealed that members of the hsp60 and hsp 70 family are highly immunodominant. Given their high conservation during evolution this was surprising, because of the apparent risk of triggering of autoimmunity and autoimmune disease during the defense of a mammal against infection ...
U, Feige, W, van Eden
openaire   +2 more sources

Autoimmune Liver Disease

The Indian Journal of Pediatrics, 2002
Autoimmune liver disorders are inflammatory liver diseases characterised histologically by a dense mononuclear cell infiltrate in the portal tract and serologically by the presence of non-organ and liver specific autoantibodies and increased levels of immunoglobulin G (IgG), in the absence of a known etiology.
Mieli-Vergani, G, Vergani, D
openaire   +3 more sources

Ménière's Disease and Autoimmunity

Annals of the New York Academy of Sciences, 1997
Identifying the etiopathogenesis of MtniBre’s disease (MD) has been the object of several studies since Prosper MCnikre first described the main symptoms of this disease in 1861 : fluctuating hearing loss, vertigo, and tinnitus. Endolymphatic hydrops is considered the main pathological finding associated with MD and a good deal of research has been ...
FILIPO, Roberto   +2 more
openaire   +3 more sources

Cancer and Autoimmune Diseases

Autoimmunity Reviews, 2017
The association between autoimmunity and cancer is well established. Cancer has been implicated in some autoimmune disorders (AID), such as scleroderma and myositis. On the other hand, many autoimmune disorders and immunosuppressive therapy, have been linked to an increased risk for cancer.
Eitan, Giat   +2 more
openaire   +2 more sources

When is an autoimmune disease not an autoimmune disease?

Immunology Today, 1994
What are the environmental triggers and genetic susceptibilities underlying the development of autoimmune diseases? These and other questions were addressed at a recent meeting in Finland.
P, Toivanen, A, Toivanen, R, Brines
openaire   +2 more sources

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