Results 41 to 50 of about 744,991 (311)

Hydroxychloroquine in patients with systemic lupus erythematosus: how much is enough?

Lupus Science and Medicine
Objective To assess the daily and weight-adjusted dosages of hydroxychloroquine (HCQ) and the effects on long-term remission in the Lupus-Cruces cohort.Methods Observational study of routine clinical care data. We selected inception patients treated with
Guillermo Ruiz-Irastorza, Daniel Martín-Iglesias, Ioana Ruiz-Arruza, Fernando Arizpe, Victor Moreno-Torres, Diana Paredes-Ruiz, Valerio Campos-Rodriguez, Laura Amo   +7 more
doaj   +1 more source

Diagnostic and therapeutic considerations in idiopathic hypereosinophilia with warm autoimmune hemolytic anemia. [PDF]

, 2015
Hypereosinophilic syndrome (HES) encompasses numerous diverse conditions resulting in peripheral hypereosinophilia that cannot be explained by hypersensitivity, infection, or atopy and that is not associated with known systemic diseases with specific ...
Brys, Adam K, Sheth, Milan R, Sohn, David D, Sweidan, Alexander J   +3 more
core   +1 more source

A Comparative Study of Demographic and Clinical Criteria Between Male and Female Patients With Pemphigus Referred to a Referral Hospital in Iran

Dermatology Research and Practice
Conclusion: The study highlights significant gender differences in the presentation and severity of pemphigus, underscoring the importance of gender-specific approaches in the diagnosis and management of this condition.
Zeinab Aryanian, Kamran Balighi, Nafiseh Esmaeli, Maryam Daneshpazhooh, Nasim Mazloomi Tootoonchi, Zahra Razavi, Fereshteh Beigmohammadi, Umamah Gul, Azadeh Khayyat, Parvaneh Hatami   +9 more
doaj   +1 more source

Two cases of neglected leishmaniasis with marked facial disfigurement: A diagnostic conundrum

Clinical Case Reports, 2023
Key Clinical Message There is a need to pay more attention to cutaneous leishmaniasis in endemic regions which may mimic other dermatoses and treatment should be initiated with a strong clinical suspicion even without any histopathologic or PCR ...
Zeinab Aryanian, Kamran Balighi, Fatameh Mohaghegh, Ifa Etesami, Zahra Razavi, Parvaneh Hatami   +5 more
doaj   +1 more source

Autoimmune diseases [PDF]

, 2009
Autoimunosne bolesti su vrlo heterogena skupina bolesti, koje imaju zajedničku karakteristiku, a to je proizvodnja autoreaktivnih T-stanica ili autoreaktivnih antitijela.
Perić, Maja
core   +3 more sources

Inpatient Food Insecurity and Pediatric Hematology Oncology Hospitalization Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Children with cancer and blood disorders are at risk for food insecurity (FI). We aimed to describe the association of inpatient food insecurity (IFI) and hospitalization outcomes among patients admitted to the pediatric hematology oncology service. Of 325 caregivers screened for IFI, 60 (18.6%) screened positive.
Joanna M. Robles, Greg Russell, Leila H. DeWitt, Kimberly Montez, Callie L. Brown   +4 more
wiley   +1 more source

Early methylprednisolone pulses and prevention of long-term damage accrual in active systemic lupus erythematosus: a propensity score analysis of the Lupus–Cruces–Bordeaux cohort

RMD Open
Objective Methylprednisolone pulses (MP) help achieve prolonged remission in patients with moderate–severe systemic lupus erythematosus (SLE), but their potential effect in reducing damage accrual has not been addressed.
Guillermo Ruiz-Irastorza, Estibaliz Lazaro, Diana Paredes-Ruiz, Beatriz Marín-García, Luis Dueña-Bartolomé, Kima López-Aldabe, Pablo Ortiz-de-Urbina   +6 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Enhanced cytotoxic effect of camptothecin nanosponges in anaplastic thyroid cancer cells in vitro and in vivo on orthotopic xenograft tumors

Drug Delivery, 2017
Anaplastic carcinoma of the thyroid (ATC) is a lethal human malignant cancer with median survival of 6 months. To date, no treatment has substantially changed its course, which makes urgent need for the development of novel drugs or novel formulations ...
Casimiro Luca Gigliotti, Benedetta Ferrara, Sergio Occhipinti, Elena Boggio, Giuseppina Barrera, Stefania Pizzimenti, Mirella Giovarelli, Roberto Fantozzi, Annalisa Chiocchetti, Monica Argenziano, Nausicaa Clemente, Francesco Trotta, Caterina Marchiò, Laura Annaratone, Renzo Boldorini, Umberto Dianzani, Roberta Cavalli, Chiara Dianzani   +17 more
doaj   +1 more source