Results 151 to 160 of about 112,037 (251)

Revisiting Ferritin‐IgG Score to Predict Complete Biochemical Response in Autoimmune Hepatitis

Alimentary Pharmacology &Therapeutics, EarlyView.
The ferritin‐IgG score failed external validation in a large Spanish multicentre cohort. However, baseline IgG ≥ 1.89×ULN independently predicted both complete biochemical response and biochemical response (defined as transaminase normalization), identifying patients less likely to achieve timely remission with standard therapy.
Álvaro Díaz‐González, Bastian Engel, Manuel Hernández‐Guerra, Indhira Pérez‐Medrano, Beatriz Mateos, Rosa M. Morillas, Elena Gómez, Judith Gómez, Diana Horta, Isabel Conde, María Del Barrio, Ignasi Olivas, Ismael El Hajra, Mar Riveiro‐Barciela, Ana Barreira‐Díaz, Carmen López, Carmen Álvarez‐Navascúes, Manuel Rodríguez Perálvarez, Elmar Jaeckel, Richard Taubert, María‐Carlota Londoño   +20 more
wiley   +1 more source

Rituximab as Salvage Therapy in Difficult-to-Treat Autoimmune Hepatitis: A Prospective Case Series. [PDF]

Gastro Hep Adv
Lammert C, Blessing N, Arif M, Minnaganti D, Weber R, Green K, Vuppalanchi R, Chalasani N.   +7 more
europepmc   +1 more source

Warm autoimmune haemolytic anaemia in Taiwan: A population‐based study of epidemiology, treatment patterns, survival and healthcare utilisation (2017–2022)

British Journal of Haematology, EarlyView.
Summary To describe the epidemiology, treatment patterns, overall survival (OS) and healthcare resource use among patients with warm autoimmune haemolytic anaemia (wAIHA) in Taiwan, adult patients with ≥1 diagnosis code for autoimmune haemolytic anaemia (AIHA) with record of wAIHA‐related treatments between 2017 and 2022 were retrospectively identified
Hsiao‐Wen Kao, Shu‐Chen Chang, Dae Young Yu, Tse‐Chih Chou, I‐Ching Tsai, Ann Leon, Alexis Krumme, David Bin‐Chia Wu, Chee Jen Chang   +8 more
wiley   +1 more source

Autoimmune Hepatitis-Primary Biliary Cholangitis Overlap Syndrome With Limited Systemic Sclerosis. [PDF]

Cureus
Vallejo Rico CF, Salazar Gonzalez GLA, Reyes Rueda J, Gonzalez Quiroz V, Garay Hernandez JA.   +4 more
europepmc   +1 more source

Acute Liver Failure During Thyroid Storm With Autoimmune Hepatitis Overlap: A Rare Immunoendocrine-Hepatic Intersection. [PDF]

ACG Case Rep J
Pacheco Oliva JG, Meléndez Rodríguez N, Castellanos AJ, Sánchez AA, Sánchez MA.   +4 more
europepmc   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Immunomodulatory effects of tacrolimus-loaded lipid-core nanocapsules in autoimmune hepatitis. [PDF]

J Autoimmun
Gomes GS, Cagle C, Li W, Visioli F, Nguyen DH, Wei A, Macha S, Csizmadia E, Bonder A, Patwardhan V, Guterres SS, Pohlmann AR, Frank LA, Longhi MS.   +13 more
europepmc   +1 more source

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

British Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu, Kaibin Dai, Zhensheng Lin, Mingfang Ye, Minfeng Chen, Xiaobo Li, Dongmei Zhang   +6 more
wiley   +1 more source

A Diagnostic Challenge: Uncovering Autoimmune Hepatitis Masked by Choledocholithiasis and Unsupervised Ivermectin Use. [PDF]

Cureus
Alqasmi H, Jawich B, Almaat AS, Taha A, Alroshood Z, Hussain MH, Siddiqui R, Tarar B, Hanayni W.   +8 more
europepmc   +1 more source

Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum

British Journal of Pharmacology, EarlyView.
Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes, Florian Buehning, Tobias Lerchner, Julia Vogel, Raluca I. Mincu, Matthias Totzeck, Tienush Rassaf, Lars Michel   +7 more
wiley   +1 more source