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Thyroid autoimmunity

La Presse Médicale, 2012
This review of human autoimmune thyroid disease (AITD) focuses mainly on the epidemiology and pathophysiology of this very common disorder, although some specific clinical situations are discussed. One peculiarity of AITD is the existence of two contrasting phenotypes: hypothyroid thyroiditis and hyperthyroid Graves' disease.
openaire   +4 more sources

Autoimmune Thyroid Disease

Annual Review of Medicine, 1986
The concept of thyroid autoimmune disease now includes the following clinical entities: 1 degree thyrotoxicosis and goitrous thyroiditis (Hashimoto) with their variants, and 1 degree myxedema (atrophic thyroiditis); some cases of sporadic nontoxic goiters; most cases of neonatal hyperthyroidism; and a proportion of congenital athyreotic cretinism ...
G F, Bottazzo, D, Doniach
openaire   +2 more sources

Autoimmune Thyroid Disease

Clinics in Laboratory Medicine, 1993
A considerable proportion of the thyroid diseases is due to aberrant immune reactions toward thyroid antigens. Autoreactivity is considered to be a normal process controlled by several suppressor mechanisms. Malfunction of these suppressor mechanisms may result in autoimmune disease.
P, Mooij, H A, Drexhage
openaire   +2 more sources

Autoimmune Thyroiditis and ROS

Autoimmunity Reviews, 2008
Autoimmune thyroiditis, also known as chronic lymphocytic or Hashimoto's thyroiditis, is characterized by infiltration of the thyroid gland by inflammatory cells and production of autoantibodies to thyroid-specific antigens thyroglobulin and thyroperoxidase.
Noel R Rose, C Lynne Burek
exaly   +3 more sources

Development of thyroid autoimmunity

Acta Endocrinologica, 1985
Abstract. Two blood samples were taken at an interval of 5 years in a continuing epidemiological study of a rural population in south-western Finland with an age range of 40–64 years at commencement. Paired sera of 680 subjects were tested for antibodies against thyroglobulin and thyroid microsomal antigen. In the seroconversion cases the titres in the
K, Aho, A, Gordin, T, Palosuo, J, Takala
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Thyroid Autoimmunity

2014
Autoimmune thyroid disease (AITD) is a multifactorial disease in which autoimmunity against thyroid antigens develops against a particular genetic background facilitated by exposure to environmental factors. Immunogenicity of the major thyroid antigens thyroid peroxidase, thyroglobulin (TG) and thyrotropin receptor (TSHR) is increased by genetic ...
openaire   +2 more sources

Autoimmune thyroid disease

Current Opinion in Rheumatology, 2012
Autoimmune thyroid disorders (AITDs) are the most common organ-specific autoimmune disorders. The genetics as well as clinical and laboratory manifestations of AITDs are reviewed.We discuss the association between specific rheumatologic disorders and AITDs and manifestations of AITDs that mimic rheumatologic disorders.
Nikolaos, Stathatos, Gilbert H, Daniels
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Autoimmunity in Thyroid Disease

New England Journal of Medicine, 1959
AUTOIMMUNE processes have been implicated in a variety of systemic disorders, including some primary hemolytic anemias, idiopathic thrombocytopenia, drug-induced neutropenias and collagenvascular diseases. The immunologic basis for such disorders has not been directly substantiated, and some investigators resist the concept that the body can develop ...
M J, CLINE, H A, SELENKOW, M S, BROOKE
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Autoimmune Thyroid Disease

Hospital Practice, 1984
Autoimmune mechanisms are responsible for only about 10% of all clinically apparent thyroid disorders. However, they play a major role in two of the three serious entities: Graves' disease and Hashimoto's thyroiditis. The complex questions that still persist with regard to the etiology and character of the autoimmune processes—and their clinical ...
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CHRONIC THYROIDITIS AND AUTOIMMUNIZATION

Journal of the American Medical Association, 1957
• An explanation of chronic thyroiditis in man was sought in observations made on rabbits, dogs, guinea pigs, and human subjects. The rabbits received injections of saline extracts of rabbit thyroid glands. The tests for circulating autoantibodies utilized the phenomena of precipitation, complement fixation, and tanned-cell hemagglutination.
E, WITEBSKY   +4 more
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