Results 11 to 20 of about 28,173 (225)
Immunotherapeutic strategies in autoimmune uveitis
Autoimmunity Reviews, 2014 Autoimmune uveitis is an organ-specific disorder characterized by irreversible lesions to the eye that predominantly affect people in their most productive years and is among the leading causes of visual deficit and blindness. Currently available therapies are effective in the treatment of a wide spectrum of uveitis, but are often associated with ...
Pedro Henrique Papotto +4 more
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Cell Reports, 2021 Summary: Gut microbiota-mediated secondary bile acids (BAs) play an important role in energy balance and host metabolism via G protein-coupled receptors and/or nuclear receptors.
Jianping Hu +9 more
doaj +3 more sources
Interleukin 35-Producing Exosomes Suppress Neuroinflammation and Autoimmune Uveitis
Frontiers in Immunology, 2020 Corticosteroids are effective therapy for autoimmune diseases but serious adverse effects preclude their prolonged use. However, immune-suppressive biologics that inhibit lymphoid proliferation are now in use as corticosteroid sparing-agents but with ...
Minkyung Kang +4 more
doaj +3 more sources
Cell Transplantation, 2018 As a featured ocular inflammatory disease, autoimmune uveitis is the major cause of blindness in the clinic. Although current immunosuppressive regimens can alleviate the progression of autoimmune uveitis, they have serious side effects.
Jinying Li +12 more
doaj +2 more sources
Cytokines in Autoimmune Uveitis [PDF]
Journal of Interferon & Cytokine Research, 2011 Autoimmune uveitis is a complex group of sight-threatening diseases that arise without a known infectious trigger. The disorder is often associated with immunological responses to retinal proteins. Experimental models of autoimmune uveitis targeting retinal proteins have led to a better understanding of the basic immunological mechanisms involved in ...
Reiko, Horai, Rachel R, Caspi
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Pattern of Uveitis in a Tertiary Hospital in North Jordan and the Impact of Behcet’s Disease
Journal of Ophthalmology, 2023 Aim. The purpose of this study is to assess the prevalence of autoimmune-mediated uveitis in relation to other diseases and to describe the clinical patterns of uveitis in a single tertiary hospital in north Jordan. Methods.
Khaldoon M. Alawneh +6 more
doaj +1 more source
Altered Metabolic Phenotype of Immune Cells in a Spontaneous Autoimmune Uveitis Model
Frontiers in Immunology, 2021 As one of the leading causes of blindness worldwide, uveitis is an important disease. The exact pathogenesis of autoimmune uveitis is not entirely elucidated to date.
Claudia Barfüßer +4 more
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TREATMENT OF UVEITIS ASSOCIATED WITH SYSTEMIC AUTOIMMUNE DISEASES IN ADULTS: A CONCISE OVERVIEW [PDF]
Romanian Journal of Rheumatology, 2017 Uveitis represents a heterogenous group of inflammatory ocular diseases which may cause vision loss. Association of uveitis with arthritis may occur in many systemic autoimmune diseases, including spondyloarthritis, juvenile idiopathic arthritis, Behҫet ...
Laura Muntean, Simona Rednic
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TNF-α in Uveitis: From Bench to Clinic
Frontiers in Pharmacology, 2021 Uveitis is an inflammation of the iris, ciliary body, vitreous, retina, or choroid, which has been shown to be the first manifestation of numerous systemic diseases.
Qi Jiang +6 more
doaj +1 more source
Multicellular immune dynamics implicate PIM1 as a potential therapeutic target for uveitis
Nature Communications, 2022 Uveitis is a complex autoimmune inflammatory disease of the eye and defining molecules involved is a priority. Here the authors use scRNA sequencing in mouse experimental autoimmune uveitis (EAU) and show PIM1 promotes the imbalance of Th17 and Treg ...
He Li +15 more
doaj +1 more source