Results 241 to 250 of about 436,604 (311)

Transcription factor EGR2 alleviates autoimmune uveitis via activation of GDF15 to modulate the retinal microglial phenotype. [PDF]

Proc Natl Acad Sci U S A
Li W, He S, Tan J, Li N, Zhao C, Wang X, Zhang Z, Liu J, Huang J, Li X, Zhou Q, Hu K, Yang P, Hou S.   +13 more
europepmc   +1 more source

Immunoregulatory Properties of Immune Cells that Associate with the Lens Capsule Surface during Acute and Resolution Phases of Experimental Autoimmune Uveitis. [PDF]

Am J Pathol
Le PM, Mattapallil MJ, Caspi RR, Stepp MA, Menko AS.   +4 more
europepmc   +1 more source

Histone deacetylases facilitate Th17-cell differentiation and pathogenicity in autoimmune uveitis via CDK6/ID2 axis. [PDF]

J Adv Res
Zhang C, Liu X, Gu C, Su Y, Lv J, Liu Y, Gao Y, Chen H, Xu N, Xiao J, Xu Z, Su W.   +11 more
europepmc   +1 more source

Characterizing autoimmune uveitis to systemic diseases: a retrospective study from a Syrian tertiary reference center. [PDF]

Ann Med Surg (Lond)
Kudsi M, Al-Darwish L, Khalayli N, Abouharb D, Abouharb L, Almajzoub R, Deeb H.   +6 more
europepmc   +1 more source

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Tregs in Autoimmune Uveitis.

Advances in Experimental Medicine and Biology, 2021
Uveitis is a chronic disease with relapsing and remitting ocular attack, which requires corticosteroids and systemic immunosuppression to prevent severe vision loss. Classically, uveitis is referred to an autoimmune disease, mediated by pro-inflammatory Th17 cells and immunosuppressive CD4+CD25+FoxP3+ T-regulatory cells (Tregs).
Zhaohao Huang, Wenli Li, W. Su
semanticscholar   +3 more sources

T cells in ocular autoimmune uveitis: Pathways and therapeutic approaches.

International Immunopharmacology, 2023
Autoimmune uveitis is a non-infectious intraocular condition that affects the uveal tract of the eye and threatens vision if not treated properly. Increasing evidence suggests that activated CD4+ T cells are associated with progressive and permanent ...
Mi Zhang, Xiaomin Zhang
semanticscholar   +1 more source

MiR-223-3p attenuates M1 macrophage polarization via suppressing the Notch signaling pathway and NLRP3-mediated pyroptosis in experimental autoimmune uveitis.

European Journal of Pharmacology, 2023
Autoimmune uveitis is an intraocular inflammatory disease with a high blindness rate in developed countries such as the United States. It is pressing to comprehend the pathogenesis of autoimmune uveitis and develop novel schemes for its treatment. In the
R. Qu, Yuan Peng, Mengxian Zhou, Shuqin Xu, Xuewei Yin, Yan Qiu, Bin Liu, Yane Gao, Hongsheng Bi, Dadong Guo   +9 more
semanticscholar   +1 more source

Prednisone acetate modulates Th1/Th2 and Th17/Treg cell homeostasis in experimental autoimmune uveitis via orchestrating the Notch signaling pathway.

International Immunopharmacology, 2023
Uveitis is an immune eye disease that can seriously impair vision. Glucocorticoids (GCS) have been extensively used to treat uveitis, though the mechanisms have not been fully elucidated.
Mengxian Zhou, R. Qu, Xuewei Yin, Yan Qiu, Yuan Peng, Bin Liu, Yan’e Gao, H. Bi, Dadong Guo   +8 more
semanticscholar   +1 more source

Single-cell sequencing of the retina shows that LDHA regulates pathogenesis of autoimmune uveitis.

Journal of Autoimmunity, 2023
Autoimmune uveitis (AU) is a severe disorder causing poor vision and blindness. However, the cellular dynamics and pathogenic mechanisms underlying retinal injury in uveitis remain unclear.
Xuening Peng, He Li, Lei Zhu, Sichen Zhao, Zhaohuai Li, Si Li, DongtingWu, Jialing Chen, S. Zheng, W. Su   +9 more
semanticscholar   +1 more source