Results 251 to 260 of about 436,604 (311)

Celastrol ameliorates experimental autoimmune uveitis through STAT3 targeting and gut microenvironment reprofiling.

International Immunopharmacology, 2023
BACKGROUND Extensive research has revealed the favorable effects of celastrol (CEL) against various diseases, but the role of CEL in autoimmune uveitis remains unexplored. METHODS We first assessed the prophylactical and therapeutical effects of CEL on
Shengjin Xiang, Jinrun Chen, Mengyun Deng, Zixiang Wang, Xingyi Li, Dan Lin, Jianhong Zhou   +6 more
semanticscholar   +1 more source

Uveitis: Autoimmunity… and beyond

Autoimmunity Reviews, 2019
Uveitis is the most common ophthalmological finding in the practice of rheumatology and clinical immunology. The condition is frequently idiopathic but about 60 causes of uveitis have been described. Our aim was to analyze the clinical patterns and etiologies of uveitis in a tertiary referral center.The records of 912 consecutive patients referred to ...
Pierre-Jean, Bertrand, Yvan, Jamilloux, René, Ecochard, Gaelle, Richard-Colmant, Mathieu, Gerfaud-Valentin, Martin, Guillaud, Philippe, Denis, Laurent, Kodjikian, Pascal, Sève   +8 more
openaire   +2 more sources

Treatment of Autoimmune Uveitis

Annals of the New York Academy of Sciences, 1993
The number of effective drugs for the treatment of autoimmune uveitis has greatly increased over the past 40 years. Many patients previously condemned to blindness can now be successfully treated with new immunosuppressive agents. New targets of the immune system, such as cell adhesion molecules, may offer novel therapeutic approaches for the treatment
S M, Whitcup, R B, Nussenblatt
openaire   +2 more sources

Ganciclovir attenuates the onset and progression of experimental autoimmune uveitis by inhibiting infiltration of Th17 and inflammatory cells into the retina.

Biochemical Pharmacology, 2022
Noninfectious (autoimmune and immune-mediated) uveitis is one of the primary diseases leading to blindness in the world. Due to the limitation of current first-line drugs for clinical uveitis, novel drugs and targets against uveitis are urgently needed ...
Jianhong Zhou, Xiang-Hua Lin, Huiping Shang, Yutuo Zhu, Jinrun Chen, M. Deng, Mali Dai, Dan Lin, S. Vakal, Yuqin Wang, Xingyi Li   +10 more
semanticscholar   +1 more source

Uveitis with autoimmune hepatic disorders

Ocular Immunology and Inflammation, 2001
Many cases of uveitis are thought to be autoimmune in nature. We report two cases of panuveitis, one of which was associated with chronic active hepatitis and the other with primary biliary cirrhosis. This suggests that the autoimmune disturbance may have been responsible for the development of the intraocular inflammation.
A, Kamal, A, Bhan, P I, Murray
openaire   +2 more sources

Polyvinylpyrrolidone-curcumin nanoparticles with immune regulatory and metabolism regulatory effects for the treatment of experimental autoimmune uveitis.

Journal of Controlled Release
Uveitis comprises a cluster of intraocular inflammatory disorders characterized by uncontrolled autoimmune responses and excessive oxidative stress leading to vision loss worldwide.
Fan Cao, Kun Liang, W. Tang, Qin-Yu Ni, Zhiyu Ji, Chen-Kai Zha, Yakun Wang, Zheng-xuan Jiang, Shengping Hou, Li-ming Tao, Xianwen Wang   +10 more
semanticscholar   +1 more source

Mouse Models of Autoimmune Uveitis

Current Pharmaceutical Design, 2015
Uveitis is a sight threatening intraocular inflammation accounting for approximately 10% of blindness worldwide. On the basis of aetiology, disease can be classified as infectious or non-infectious; and by anatomical localization of inflammation as anterior, posterior and panuveitis.
Izabela P, Klaska, John V, Forrester
openaire   +2 more sources

Microglial mediators in autoimmune Uveitis: Bridging neuroprotection and neurotoxicity.

International Immunopharmacology
Autoimmune uveitis, a severe inflammatory condition of the eye, poses significant challenges due to its complex pathophysiology and the critical balance between protective and detrimental immune responses.
Monika Sharma, Pankaj Pal, Sukesh Kumar Gupta   +2 more
semanticscholar   +1 more source

Activation of the interleukin-23/interleukin-17 signalling pathway in autoinflammatory and autoimmune uveitis.

Progress in retinal and eye research, 2020
Uveitis is a group of diseases characterized by intraocular inflammation, of which some are driven by autoinflammatory or autoimmune responses, such as Vogt-Koyanagi-Harada disease, Behçet's disease, uveitis associated with spondyloarthritis, ocular ...
Zhenyu Zhong, Guannan Su, A. Kijlstra, Peizeng Yang   +3 more
semanticscholar   +1 more source

Cutting-Edge Issues in Autoimmune Uveitis

Clinical Reviews in Allergy & Immunology, 2011
Autoimmune uveitis (AIU) is among the leading causes of preventable blindness. It can be isolated, precede, or appear in the course of a systemic autoimmune inflammatory disease. When suspected, AIU should be promptly referred to an ophthalmologist for proper anatomic classification and local treatment.
Roger A, Levy, Francisco Assis, de Andrade, Ivan, Foeldvari   +2 more
openaire   +2 more sources