Results 261 to 270 of about 436,604 (311)

Biologic agents in experimental autoimmune uveitis

International Ophthalmology, 2013
Experimental uveitis models were developed in an effort to elucidate the pathogenesis of human uveitis. The therapeutic effects of numerous anti-inflammatory agents including corticosteroids and immunomodulatory agents including biologic response modifiers have been investigated in both experimental and human uveitis.
Gian Paolo, Giuliari, Ama, Sadaka, David M, Hinkle   +2 more
openaire   +2 more sources

Uveitis in Patients with Autoimmune Hepatitis

American Journal of Ophthalmology, 2009
To report seven cases of uveitis occurring in patients with autoimmune hepatitis (AIH), raising the possibility that uveitis may be an extrahepatic feature of AIH.Multicenter, retrospective, observational case series of patients with AIH and uveitis.One index case was identified at Oregon Health & Science University.
Lyndell L, Lim, John D, Scarborough, Jennifer E, Thorne, Elizabeth, Graham, John H, Kempen, Friederike, Mackensen, Quan Dong, Nguyen, Tisha, Prabriputaloong, Russell W, Read, Eric B, Suhler, Jonathan M, Schwartz, Justine R, Smith   +11 more
openaire   +2 more sources

Uveitis Complicating Autoimmune Chronic Active Hepatitis

Archives of Pediatrics & Adolescent Medicine, 1983
A patient with autoimmune hepatitis B surface antigen-negative chronic active hepatitis (CAH) developed uveitis during the course of her disease. The occurrence of this eye disorder provides additional support for an autoimmune pathogenesis for CAH.
J N, Bloom, I M, Rabinowicz, S T, Shulman   +2 more
openaire   +2 more sources

Uveitis and Autoimmune Diseases

2019
The uvea is the predilection site of ocular immune diseases, due to its features like peripheral immune organ, with abundant vessels and some other ocular antigenic substances such as lens and retinal antigens, which could easily induce the immune-related ocular diseases. Uveitis has many complex symptoms, signs, and causes.
Meifen Zhang, Bo Wan
openaire   +1 more source

Targeting interleukin-6 in autoimmune uveitis

Autoimmunity Reviews, 2017
Interleukin-6 (IL-6) is a key cytokine that is strongly up-regulated during infection and inflammation. Featuring pleiotropic activity, IL-6 is responsible for the induction of hepatic acute-phase proteins, trafficking of acute and chronic inflammatory cells, differentiation of adaptive T cell responses, homeostatic regulation, and tissue regeneration.
Marina, Mesquida, Blanca, Molins, Víctor, Llorenç, Maite Sáinz, de la Maza, Alfredo, Adán   +4 more
openaire   +2 more sources

A combination of inhibiting microglia activity and remodeling gut microenvironment suppresses the development and progression of experimental autoimmune uveitis.

Biochemical Pharmacology, 2020
Noninfectious (autoimmune and immune-mediated) uveitis is an ocular inflammatory disease which can lead to blindness in severe cases. Due to the potential side effects of first-line drugs for clinical uveitis, novel drugs and targets against uveitis are ...
Jianhong Zhou, Jingjing Yang, Mali Dai, Dan Lin, Renshu Zhang, Hui Liu, Ailing Yu, S. Vakal, Yuqin Wang, Xingyi Li   +9 more
semanticscholar   +1 more source

Mechanisms Underlying Autoimmune Uveitis

Drug Discovery Today: Disease Mechanisms, 2006
Autoimmune uveitis is a group of HLA-associated inflammatory diseases of the eye, which can cause blindness. Patients exhibit cellular and humoral responses to immunologically privileged antigens resident in the eye. Animal models of uveitis, induced with these retinal antigens, serve an important role in studying disease mechanisms and therapies.
openaire   +1 more source

T_regLymphocytes in Autoimmune Uveitis

Ocular Immunology and Inflammation, 2012
To evaluate circulating CD4(+)CD25(+) regulatory T-cell populations in patients with autoimmune uveitis and to assess whether T-regulatory cell populations correlate with clinical features.Sixty-four patients with noninfectious uveitis were enrolled.
Ruggieri S, Frassanito MA, DAMMACCO, ROSANNA, GUERRIERO, Silvana   +3 more
openaire   +2 more sources

Effect of berberine on spleen transcriptome and gut microbiota composition in experimental autoimmune uveitis.

International Immunopharmacology, 2020
BACKGROUND Berberine (BBR) was reported to have immunoregulatory and anti-inflammatory properties. In this study, we investigated whether BBR could exert its effects on the development of experimental autoimmune uveitis (EAU), and if so, what was the ...
Ziyu Du, Qingfeng Wang, Xinyue Huang, S. Yi, S. Mei, G. Yuan, Guannan Su, Qingfeng Cao, Chunjiang Zhou, Yao Wang, A. Kijlstra, Peizeng Yang   +11 more
semanticscholar   +1 more source

Diagnosis and classification of autoimmune uveitis

Autoimmunity Reviews, 2014
Uveitis is the most common ophthalmological finding in the practice of rheumatology and clinical immunology. The condition is frequently idiopathic and defined by the inflammatory status of the uvea, the part of the middle eye that includes the iris, ciliary body and choroid. Anterior uveitis involves the iris and ciliary body, while the posterior form
openaire   +3 more sources